Extracellular vesicle therapeutics for liver disease

Borrelli, David A.; Yankson, Kiera; Shukla, Neha; Vilanilam, George K.; Ticer, Taylor; Wolfram, Joy

doi:10.1016/j.jconrel.2018.01.022

Cited by 98 publications

(84 citation statements)

References 138 publications

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“…In this study, the potential protective effects of BiNPs against apoptotic (ethanol) and oxidative stress‐inducing (hydrogen peroxide) agents were assessed. Macrophages were chosen as an in vitro model of cell stress as the largest portion of intravenously administered nanoparticles (synthetic or biological) are internalized by circulating or resident macrophages 1,41–44. Moreover, macrophages play a major role in tissue regeneration and several studies have demonstrated that the depletion of these cells causes impaired tissue repair 45,46.…”

Section: Resultsmentioning

confidence: 99%

“…Macrophages were chosen as an in vitro model of cell stress as the largest portion of intravenously administered nanoparticles (synthetic or biological) are internalized by circulating or resident macrophages. [1,[41][42][43][44] Moreover, macrophages play a major role in tissue regeneration and several studies have demonstrated that the depletion of these cells causes impaired tissue repair. [45,46] Cell viability studies demonstrated that both Lipo-NPs and ADSC-EVs protected macrophages from hydrogen peroxide ( Figure 4A) and ethanol-induced stress ( Figure 4B) to a similar extent.…”

Section: Protective Effects Of Lipo-nps and Adsc-evs In Macrophagesmentioning

confidence: 99%

“…Extracellular vesicles (EVs) are naturally occurring nanoparticles secreted by all cells, and serve important roles in many physiological processes, including immunomodulation. [1] Increasing evidence has shown that therapeutic effects of cell therapy are elicited through the release of secreted EV cargo, such as RNA, proteins, and lipids. [2][3][4][5][6] EVs have many advantages over cell therapy, including easier storage, eliminated risk of malignant transformation, prolonged circulation times, and increased stability.…”

Section: Introductionmentioning

confidence: 99%

“…[2][3][4][5][6] EVs have many advantages over cell therapy, including easier storage, eliminated risk of malignant transformation, prolonged circulation times, and increased stability. [1] In particular, mesenchymal stem cell (MSC)-derived EVs have demonstrated great potential as therapeutic agents in various disease models. For example, ADSC-EVs have been shown to induce anti-inflammatory, anti-oxidant, anti-apoptotic, and angiogenic effects in neurological, genitourinary, organ-specific, and endocrine disorders, as well plastic surgery and regenerative applications.…”

Section: Introductionmentioning

confidence: 99%

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Adipose‐Derived Biogenic Nanoparticles for Suppression of Inflammation

Tian

Ticer

Wang

et al. 2020

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Extracellular vesicles secreted from adipose‐derived mesenchymal stem cells (ADSCs) have therapeutic effects in inflammatory diseases. However, production of extracellular vesicles (EVs) from ADSCs is costly, inefficient, and time consuming. The anti‐inflammatory properties of adipose tissue‐derived EVs and other biogenic nanoparticles have not been explored. In this study, biogenic nanoparticles are obtained directly from lipoaspirate, an easily accessible and abundant source of biological material. Compared to ADSC‐EVs, lipoaspirate nanoparticles (Lipo‐NPs) take less time to process (hours compared to months) and cost less to produce (clinical‐grade cell culture facilities are not required). The physicochemical characteristics and anti‐inflammatory properties of Lipo‐NPs are evaluated and compared to those of patient‐matched ADSC‐EVs. Moreover, guanabenz loading in Lipo‐NPs is evaluated for enhanced anti‐inflammatory effects. Apolipoprotein E and glycerolipids are enriched in Lipo‐NPs compared to ADSC‐EVs. Additionally, the uptake of Lipo‐NPs in hepatocytes and macrophages is higher. Lipo‐NPs and ADSC‐EVs have comparable protective and anti‐inflammatory effects. Specifically, Lipo‐NPs reduce toll‐like receptor 4‐induced secretion of inflammatory cytokines in macrophages. Guanabenz‐loaded Lipo‐NPs further suppress inflammatory pathways, suggesting that this combination therapy can have promising applications for inflammatory diseases.

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Section: Resultsmentioning

confidence: 99%

Section: Protective Effects Of Lipo-nps and Adsc-evs In Macrophagesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Adipose‐Derived Biogenic Nanoparticles for Suppression of Inflammation

Tian

Ticer

Wang

et al. 2020

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“…21 Biological materials are also being investigated including viral vectors for the delivery of gene-based therapeutics, and more recently extracellular vesicles have been receiving interest for drug delivery. [22][23][24] Among the materials developed for drug delivery systems, polymers have possibly been studied the most. Advances in synthetic polymer chemistry and coupling techniques, have led to the ability to precisely control both nanomaterial composition and function.…”

Section: Introductionmentioning

confidence: 99%

Branched and Dendritic Polymer Architectures: Functional Nanomaterials for Therapeutic Delivery

Cook

Perrier

2019

Adv Funct Materials

126

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Barriers to therapeutic transport in biological systems can prevent accumulation of drugs at the intended site, thus limiting the therapeutic effect against various diseases. Advances in synthetic chemistry techniques have recently increased the accessibility of complex polymer architectures for drug delivery systems, including branched polymer architectures. This article first outlines drug delivery concepts, and then defines and illustrates all forms of branched polymers including highly branched polymers, hyperbranched polymers, dendrimers, and branched–linear hybrid polymers. Many new types of branched and dendritic polymers continue to be reported; however, there is often confusion about how to accurately describe these complex polymer architectures, particularly in the interdisciplinary field of nanomedicine where not all researchers have in‐depth polymer chemistry backgrounds. In this context, the present review describes and compares different branched polymer architectures and their application in therapeutic delivery in a simple and easy‐to‐understand way, with the aim of appealing to a multidisciplinary audience.

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Extracellular Vesicles and Exosomes

Szabó

Momen-Heravi

2020

The Liver

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Extracellular vesicle therapeutics for liver disease

Cited by 98 publications

References 138 publications

Adipose‐Derived Biogenic Nanoparticles for Suppression of Inflammation

Adipose‐Derived Biogenic Nanoparticles for Suppression of Inflammation

Branched and Dendritic Polymer Architectures: Functional Nanomaterials for Therapeutic Delivery

Extracellular Vesicles and Exosomes

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