Extracellular superoxide dismutase, a molecular transducer of health benefits of exercise

Yan, Zhen; Spaulding, Hannah R.

doi:10.1016/j.redox.2020.101508

Cited by 100 publications

(106 citation statements)

References 117 publications

(155 reference statements)

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“…A recent work reported that higher levels of physical activity were associated with lower levels of anxiety during COVID-19 [30]. Research has further reinforced that physical activity has played an important role in physical health during COVID-19 [31,32]. Furthermore, our results revealed gender-related differences, with men showing significantly higher levels of physical activity compared to women.…”

Section: Discussionsupporting

confidence: 66%

Exploring Lifestyle Habits, Physical Activity, Anxiety and Basic Psychological Needs in a Sample of Portuguese Adults during COVID-19

Antunes

Frontini

Amaro

et al. 2020

IJERPH

167

175

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This cross-sectional study aimed to characterize the lifestyle habits, anxiety levels and basic psychological needs (BPN), in Portuguese adults during the Coronavirus Disease 2019 (COVID-19) pandemic, including a comparison between genders and age groups. In total, 1404 adults (36.4 ± 11.7 years; 69.6% female) answered sociodemographic data and three instruments: the International Physical Activity Questionnaire, the Basic Need General Satisfaction Scale and the State-Trait Anxiety Inventory. Males revealed higher values for the total energy expenditure (z = −2.26; p = 0.024; η 2 = 0.004) and for the level of satisfaction of competence (z = −2.62; p = 0.009; η 2 = 0.005). Females showed higher scores for the anxiety state (z = −7.87; p ≤ 0.001; η 2 = 0.044) and anxiety trait (z = −6.49; p ≤ 0.001; η 2 = 0.030). Regarding age, higher values for the anxiety trait (p ≤ 0.001; η H 2 = 0.030) were found in the 18–34 years-old group compared to all the other age groups, also presenting significantly higher values of total energy expenditure (χ² = 13.93; p = 0.008; η H 2 = 0.007) when compared to the 35–44 years-old group. Significant differences were observed between the 18–34 years-old group and the other age groups for the satisfaction of competence (χ² = 40.97; p ≤ 0.001; η H 2 = 0.026), except for the >65 years-old group. Strategies for promoting well-being during periods of social isolation should consider the role of psychological dimensions and lifestyle habits according to the gender or age group.

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Section: Discussionsupporting

confidence: 66%

Exploring Lifestyle Habits, Physical Activity, Anxiety and Basic Psychological Needs in a Sample of Portuguese Adults during COVID-19

Antunes

Frontini

Amaro

et al. 2020

IJERPH

167

175

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“…During infection by the novel coronavirus, excessive secretion of these molecules by the immune cells mediates a massive pulmonary infiltrate of neutrophils, monocytes and macrophages, which results in alveolar damage due to wall thickening and formation of hyaline membranes. In addition, the accumulation of neutrophils in the lungs increases the production of reactive oxygen species (ROS) and pro-inflammatory molecules, predisposing to injury [41]. Therefore, high levels of pro-inflammatory cytokines are associated with respiratory insufficiency, ARDS and may lead to shock, MOF and death in the COVID-19 [37,38].…”

Section: Cytokine Stormmentioning

confidence: 99%

“…As seen, innate immunity has an important role in the pathogenesis of COVID-19 and ARDS, due to inflammatory cascades, recruitment of neutrophils, macrophages and DC cells and increased production of ROSs. In turn, by the modulation mechanism of chemokine production, physical training and therapeutic exercises can attenuate alveolar neutrophilia in the face of lung injury [41].…”

Section: Physical Exercise and Covid-19mentioning

confidence: 99%

Physical exercise as a tool to help the immune system against COVID-19: an integrative review of the current literature

et al. 2020

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Acute viral respiratory infections are the main infectious disease in the world. In 2020, a new disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), coronavirus disease 2019 (COVID-19), became a global pandemic. The immune response to the virus depends on factors such as genetics, age and physical state, and its main input receptor is the angiotensin-converting enzyme 2. The practice of physical exercises acts as a modulator of the immune system. During and after physical exercise, pro-and anti-inflammatory cytokines are released, lymphocyte circulation increases, as well as cell recruitment. Such practice has an effect on the lower incidence, intensity of symptoms and mortality in viral infections observed in people who practice physical activity regularly, and its correct execution must be considered to avoid damage. The initial response is given mainly by type I interferons (IFN-I), which drive the action macrophages and lymphocytes, followed by lymphocyte action. A suppression of the IFN-I response has been noted in COVID-19. Severe conditions have been associated with storms of pro-inflammatory cytokines and lymphopenia, as well as circulatory changes and virus dispersion to other organs. The practice of physical activities strengthens the immune system, suggesting a benefit in the response to viral communicable diseases. Thus, regular practice of adequate intensity is suggested as an auxiliary tool in strengthening and preparing the immune system for COVID-19. Further studies are needed to associate physical exercise with SARS-CoV-2 infection.

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“…The acute lung injury in ARDS results from high levels of neutrophil activation and accumulation of reactive oxygen species and pro-inflammatory mediators. Extracellular Superoxide Dismutase (EcSOD) prevents oxidative stress and damage through extracellular scavenging of superoxide anions [115]. Yan and Spalding described the role of exercise in increasing EcSOD, initially enhancing EcSOD expression in skeletal muscle and then redistributing to lung tissue.…”

Section: Prevention and Reduction In Reactive Oxygen Speciesmentioning

confidence: 99%

“…Yan and Spalding described the role of exercise in increasing EcSOD, initially enhancing EcSOD expression in skeletal muscle and then redistributing to lung tissue. This role is a possible preventative or therapeutic option for reducing risk and severity of ARDS in COVID-19 [115].…”

Section: Prevention and Reduction In Reactive Oxygen Speciesmentioning

confidence: 99%

Exercise for Older Adults Improves the Quality of Life in Parkinson’s Disease and Potentially Enhances the Immune Response to COVID-19

Hall

Church

2020

Brain Sciences

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Parkinson’s disease (PD) is a progressive neurodegenerative disorder brought about due to dopaminergic neuronal cell loss in the midbrain substantia nigra pars compacta region. PD presents most commonly in older adults and is a disorder of both motor and nonmotor dysfunction. The novel SARS-CoV-2 virus is responsible for the recent COVID-19 pandemic, and older individuals, those with preexisting medical conditions, or both have an increased risk of developing COVID-19 with more severe outcomes. People-with-Parkinson’s (PwP) of advanced age can have both immune and autonomic nervous problems that potentially lead to pre-existing pulmonary dysfunction and higher infection risk, increasing the probability of contracting COVID-19. A lifestyle change involving moderate-intensity exercise has the potential to protect against SARS-CoV-2 through strengthening the immune system. In addition to a potential protective measure against SARS-CoV-2, exercise has been shown to improve quality-of-life (QoL) in PD patients. Recent studies provide evidence of exercise as both neuroprotective and neuroplastic. This article is a literature review investigating the role exercise plays in modifying the immune system, improving health outcomes in PwP, and potentially acting as a protective measure against SARS-Cov-2 infection. We conclude that exercise, when correctly performed, improves QoL and outcomes in PwP, and that the enhanced immune response from moderate-intensity exercise could potentially offer additional protection against COVID-19.

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Extracellular superoxide dismutase, a molecular transducer of health benefits of exercise

Cited by 100 publications

References 117 publications

Exploring Lifestyle Habits, Physical Activity, Anxiety and Basic Psychological Needs in a Sample of Portuguese Adults during COVID-19

Exploring Lifestyle Habits, Physical Activity, Anxiety and Basic Psychological Needs in a Sample of Portuguese Adults during COVID-19

Physical exercise as a tool to help the immune system against COVID-19: an integrative review of the current literature

Exercise for Older Adults Improves the Quality of Life in Parkinson’s Disease and Potentially Enhances the Immune Response to COVID-19

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