2012
DOI: 10.1016/j.arcmed.2012.07.007
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Extracellular Matrix Remodeling in Takayasu's Arteritis: Role of Matrix Metalloproteinases and Adventitial Inflammation

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Cited by 22 publications
(20 citation statements)
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“…In corroboration, increased serum levels of MMPs and gelatinolytic activities of MMPs have been demonstrated in TA subjects [14, 17, 4447]. Various cytokines and chemokines, like interleukin-6 (IL-6), regulated on activation normal T cell expressed and secreted (RANTES), and monocytic chemotactic protein-1 (MCP-1), are reported to increase in patients with TA and therefore could possibly accelerate the production of MMPs by inflammatory [16, 47, 48].…”
Section: Mmp-timp Axis In Pathophysiology Of Takayasu's Arteritismentioning
confidence: 63%
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“…In corroboration, increased serum levels of MMPs and gelatinolytic activities of MMPs have been demonstrated in TA subjects [14, 17, 4447]. Various cytokines and chemokines, like interleukin-6 (IL-6), regulated on activation normal T cell expressed and secreted (RANTES), and monocytic chemotactic protein-1 (MCP-1), are reported to increase in patients with TA and therefore could possibly accelerate the production of MMPs by inflammatory [16, 47, 48].…”
Section: Mmp-timp Axis In Pathophysiology Of Takayasu's Arteritismentioning
confidence: 63%
“…In an important in vitro study, Mahajan et al demonstrated that a direct contact between activated T-lymphocytes (isolated from TA subjects) and HT1080 fibroblast leads to enhanced expression of MMPs. Subcellular fractionation studies with T cells isolated from TA subjects pointed out the presence of some unidentified antigenic moiety in membrane fraction which is responsible for the enhanced expression of MMPs by HT1080 cells [44]. Therefore, interaction of different cells in the adventitial setting generates a microenvironment which channelizes cells to invade the media and intima through adventitia due to augmented MMP expression.…”
Section: Mmp-timp Axis In Pathophysiology Of Takayasu's Arteritismentioning
confidence: 99%
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“…There is much evidence that matrix metalloproteinases (MMPs) are involved in the balance between the breakdown and synthesis of extracellular matrix, which determines the risk of rupture of plaques and subsequent disease events [7,43]. MMPs and their inhibitors (TIMPs) have already been demonstrated as potential factors in the pathophysiology of various disease settings [43][44][45][46].…”
Section: Interleukin 18 As Biomarker In Atherosclerosismentioning
confidence: 99%
“…It is generally accepted that a complex endothelial dysfunction induced by free radicals, low-density lipoproteins (LDL), infectious microorganism, shear stress, toxins, hypertension or a combination of these and other factors lead to the development of atherosclerosis. Besides implication of inflammation and immune reactions in this process, a wide range of circulating markers of inflammation has also been demonstrated to predict cardiovascular event in a variety of clinical settings [1,3,4,[6][7][8].…”
Section: Introductionmentioning
confidence: 99%