Interleukin-18 and Atherosclerosis: Mediator or Biomarker

Mahajan, Kunal

doi:10.4172/2155-9880.1000352

Cited by 5 publications

(5 citation statements)

References 56 publications

(83 reference statements)

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“…Cainzos-Achirica et al explored the prognostic value of IL-6 for the prediction of atherosclerotic cardiovascular disease (ASCVD) events, HF, and other chronic diseases in 6617 participants and concluded that IL-6 is strongly and independently associated with ASCVD events, HF, and all-cause mortality, particularly among statin users [53]. IL-18 is another promising prognostic marker for CAD [54]. Opstad at al.…”

Section: Inflammation Biomarkersmentioning

confidence: 99%

Sudden Cardiac Death (SCD) – risk stratification and prediction with molecular biomarkers

et al. 2019

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Sudden cardiac death (SCD) is a sudden, unexpected death that is caused by the loss of heart function. While SCD affects many patients suffering from coronary artery diseases (CAD) and heart failure (HF), a considerable number of SCD events occur in asymptomatic individuals. Certain risk factors for SCD have been identified and incorporated in different clinical scores, however, risk stratification using such algorithms is only useful for health management rather than for early detection and prediction of future SCD events in high-risk individuals. In this review, we discuss different molecular biomarkers that are used for early detection of SCD. This includes genetic biomarkers, where the majority of them are genomic variants for genes that encode for ion channels. Meanwhile, protein biomarkers often denote proteins that play roles in pathophysiological processes that lead to CAD and HF, notably (i) atherosclerosis that involves oxidative stress and inflammation, as well as (ii) cardiac tissue damage that involves neurohormonal and hemodynamic regulation and myocardial stress. Finally, we outline existing challenges and future directions including the use of OMICS strategy for biomarker discovery and the multimarker panels.

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Section: Inflammation Biomarkersmentioning

confidence: 99%

Sudden Cardiac Death (SCD) – risk stratification and prediction with molecular biomarkers

et al. 2019

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“…This cytokine is among the more recently recognized cytokines to be involved in the development of various cardiovascular diseases. At one end, studies indicate that IL-18 is a key player that orchestrates the inflammatory cascade associated with the pathogenesis of atherosclerosis whereas others show circulating IL-18 levels to be a prognostic marker [48].…”

Section: Interleukinesmentioning

confidence: 99%

New Insights into Inflammation in Atherosclerosis

Naafs¹

2018

GJEM

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In this mini-review recent developments in the pathogenesis, pathophysiology, biomarkers and therapeutics in residual inflammation of atherosclerosis are discussed. New cellular pathways are discovered raise new interest in old therapeutics as colchicine and niacin. Biomarker studies call for more specific and sensitive markers. The recent CANTOS trial provided clinicians evidence that directly targeting inflammation by canakinumab is beneficial for the secondary prevention of cardiovascular disease. Whole genome and exome studies will lead to the discovery of new cellular pathways and treatments of residual atherosclerotic inflammation.

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“…Interleukin-18 (IL-18) is a pro-inflammatory cytokine with a critical role in the inflammation that adds to atherosclerosis [6]. Expanded levels of circulating IL-18 have been might be connected with quickening of atherosclerosis and H EART disease is impacted by ecological and inherited factors.…”

Section: Introductionmentioning

confidence: 99%

“…Variations in the IL-18 gene were connected with raised IL-18 serum focuses and higher cardiovascular mortality among CAD patients. Distinctive studies showed that IL18 polymorphisms are incorporated into the advancement of ischemic stroke [8], dead tissue [9], and higher cardiovascular mortality risk [6].…”

Section: Introductionmentioning

confidence: 99%