Extracellular Matrix Remodeling in Intestinal Homeostasis and Disease

Lee, Sang-Eun; Massie, Isobel; Meran, Laween; Li, Vivian

doi:10.1016/bs.asn.2018.01.001

Cited by 9 publications

(7 citation statements)

References 202 publications

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“…The ECM does not represent a static structure, but a dynamic tissue component that constantly undergoes continuous remodeling (10,11,18,22,62). The homeostasis of healthy tissue is guaranteed by a continuous and balanced deposition, degradation, and modification of the ECM and an imbalance in this equilibrium can lead to pathological conditions (63)(64)(65).…”

Section: Ecm Is a Dynamic Structure: Cellular And Molecular Functionsmentioning

confidence: 99%

“…The homeostasis of healthy tissue is guaranteed by a continuous and balanced deposition, degradation, and modification of the ECM and an imbalance in this equilibrium can lead to pathological conditions (63)(64)(65). A large number of molecules and growth factors orchestrate this delicate process by regulating ECM amount, composition, and structure (10,11,18,62). Intestinal fibrosis, characterized by an abnormal deposition of ECM, represents the main chronic complication of inflammatory bowel disease (IBD), chronic relapsing intestinal disorders including Crohn's disease, which can affect both the small and large intestine, and ulcerative colitis, which only affects the large intestine (5,10).…”

Section: Ecm Is a Dynamic Structure: Cellular And Molecular Functionsmentioning

confidence: 99%

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The Charming World of the Extracellular Matrix: A Dynamic and Protective Network of the Intestinal Wall

et al. 2021

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The intestinal extracellular matrix (ECM) represents a complex network of proteins that not only forms a support structure for resident cells but also interacts closely with them by modulating their phenotypes and functions. More than 300 molecules have been identified, each of them with unique biochemical properties and exclusive biological functions. ECM components not only provide a scaffold for the tissue but also afford tensile strength and limit overstretch of the organ. The ECM holds water, ensures suitable hydration of the tissue, and participates in a selective barrier to the external environment. ECM-to-cells interaction is crucial for morphogenesis and cell differentiation, proliferation, and apoptosis. The ECM is a dynamic and multifunctional structure. The ECM is constantly renewed and remodeled by coordinated action among ECM-producing cells, degrading enzymes, and their specific inhibitors. During this process, several growth factors are released in the ECM, and they, in turn, modulate the deposition of new ECM. In this review, we describe the main components and functions of intestinal ECM and we discuss their role in maintaining the structure and function of the intestinal barrier. Achieving complete knowledge of the ECM world is an important goal to understand the mechanisms leading to the onset and the progression of several intestinal diseases related to alterations in ECM remodeling.

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Section: Ecm Is a Dynamic Structure: Cellular And Molecular Functionsmentioning

confidence: 99%

Section: Ecm Is a Dynamic Structure: Cellular And Molecular Functionsmentioning

confidence: 99%

The Charming World of the Extracellular Matrix: A Dynamic and Protective Network of the Intestinal Wall

et al. 2021

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“…Apart from the obvious role of participation in the absorption of water and nutrients Toxins 2021, 13, 758 2 of 25 (products of digestion), as a highly dynamic barrier between the external environment (intestinal lumen) and human tissues, it plays also a modulatory role between the gut microbiota and the central nervous system (CNS). The presence of the continuous and integral barrier allows the body to maintain homeostasis [3], and dead cells are replaced with new ones derived from intestinal stem cell niches (ISCs) [4].…”

Section: Intestinal Barrier: In Health and Diseasementioning

confidence: 99%

Intestinal Barrier, Claudins and Mycotoxins

Kozieł

Ziaja

Piastowska-Ciesielska

2021

Toxins

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The intestinal barrier is the main barrier against all of the substances that enter the body. Proper functioning of this barrier guarantees maintained balance in the organism. Mycotoxins are toxic, secondary fungi metabolites, that have a negative impact both on human and animal health. It was postulated that various mycotoxins may affect homeostasis by disturbing the intestinal barrier. Claudins are proteins that are involved in creating tight junctions between epithelial cells. A growing body of evidence underlines their role in molecular response to mycotoxin-induced cytotoxicity. This review summarizes the information connected with claudins, their association with an intestinal barrier, physiological conditions in general, and with gastrointestinal cancers. Moreover, this review also includes information about the changes in claudin expression upon exposition to various mycotoxins.

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“…Uncontrolled remodeling of the host extracellular matrix (ECM) is a known hallmark of inflammatory bowel disease (IBD) ( 1 – 6 ). The intestinal ECM consists of a combination of proteins, glycoproteins, and proteoglycans that provide not only mechanical support but also important biochemical cues for the development and homeostasis of the colon ( 7 ). For example, the basement membrane ECM beneath the mucosal epithelium helps maintain intestinal barrier integrity, and the interstitial matrix ECM supports both the structural integrity and the remodeling of the submucosa ( 1 ).…”

Section: Introductionmentioning

confidence: 99%