“…Moreover, integrins have been identified in exosomes, and their transfer through these vesicles is implicated in the promotion of cell adhesion, migration and the determination of organotropism in metastatic dissemination [ 58 , 91 ]. During retinal development, ECM constituents play versatile roles, which include cellular proliferation, differentiation, migration, adhesion and maturation, as well as axonal growth and guidance [ 92 , 93 , 94 , 95 ]. ECM components and their remodeling have a crucial role in several diseases of the retina, such as retinal injury and cancer, where changes in the interaction of cells and ECM components occur with a consequent disruption of the retinal homeostasis [ 96 , 97 ].…”