Extracellular matrix in airway smooth muscle is associated with dynamics of airway function in asthma

Yick, Ching Yong; Ferreira, Diogenes S.; Annoni, Raquel; Thüsen, Jan H. von der; Kunst, Peter W.A.; Bel, Elisabeth H.; Lutter, René; Mauad, Thaís; Sterk, Peter J.

doi:10.1111/j.1398-9995.2011.02773.x

Cited by 40 publications

(42 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, single nucleotide polymorphisms in the Dcn gene were not found to be a risk factor in the development of COPD [156]. As these results differ from those obtained with patients suffering from milder forms of COPD, where biglycan and decorin levels are not different from controls [136], it is apparent that severe modifications in the ECM occur only in the later stages of COPD.…”

Section: Slrps In Lung Diseasementioning

confidence: 99%

See 1 more Smart Citation

Key roles for the small leucine-rich proteoglycans in renal and pulmonary pathophysiology

Nastase

Iozzo

Schaefer

2014

Biochimica et Biophysica Acta (BBA) - General Subjects

View full text Add to dashboard Cite

Background Small leucine-rich proteoglycans (SLRPs) are molecules that have signaling roles in a multitude of biological processes. In this respect, SLRPs play key roles in the evolution of a variety of diseases throughout the human body. Scope of Review We will critically review current developments in the roles of SLRPs in several types of disease of the kidney and lungs. Particular emphasis will be given to the roles of decorin and biglycan, the best characterized members of the SLRP gene family. Major Conclusions In both renal and pulmonary disorders, SLRPs are essential elements that regulate several pathophysiological processes including fibrosis, inflammation and tumor progression. Decorin has remarkable antifibrotic and antitumorigenic properties and is considered a valuable potential treatment of these diseases. Biglycan can modulate inflammatory processes in lung and renal inflammation and is a potential target in the treatment of inflammatory conditions. General significance SLRPs can serve as either treatment targets or as potential treatment in renal or lung disease.

show abstract

Section: Slrps In Lung Diseasementioning

confidence: 99%

“…A key role in airway remodeling is held by the potential of the ASM cells to modulate and interact with the extracellular matrix environment [134–136]. Besides their different features at the expression level decorin has also functional effects on lung mechanics, in ammation, and airway remodeling in allergic asthma [122].…”

Section: Slrps In Lung Diseasementioning

confidence: 99%

Key roles for the small leucine-rich proteoglycans in renal and pulmonary pathophysiology

Nastase

Iozzo

Schaefer

2014

Biochimica et Biophysica Acta (BBA) - General Subjects

View full text Add to dashboard Cite

show abstract

“…Structural changes of the airway wall, collectively called airway remodeling, are likely to contribute to these functional changes (5). More specifically, airway smooth muscle (ASM) mass, elevated mast cell counts, and extracellular matrix (ECM) deposition within the ASM layer are associated with the clinical expression and severity of asthma (6)(7)(8)(9). This suggests that ASM plays an important role in the pathophysiology of asthma and therefore in being a potential target in the treatment of this disease.…”

mentioning

confidence: 97%

Glucocorticoid-induced Changes in Gene Expression of Airway Smooth Muscle in Patients with Asthma

Yick¹,

Zwinderman²,

Kunst

et al. 2013

Am J Respir Crit Care Med

View full text Add to dashboard Cite

show abstract

“…They are thus likely to modulate both bronchoconstriction and airway reopening. In asthmatic patients, ECM in the ASM has been positively correlated with changes in the dynamics of airway function (47) possibly as a result of alterations of the type and spatial organization of the collagen fibers. However, others have failed to link mechanical properties and airway collagen content in asthma (4,14).…”

mentioning

confidence: 98%

Airway collagen and elastic fiber content correlates with lung function in equine heaves

Setlakwe

Lemos

Lavoie-Lamoureux

et al. 2014

American Journal of Physiology-Lung Cellular and Molecular Phys

View full text Add to dashboard Cite

The consequences on lung function and inflammation of alterations in the extracellular matrix affecting the peripheral airway wall in asthma are largely unknown. We hypothesized that remodeling of collagen and elastic fibers in the peripheral airway wall leads to airway obstruction and contributes to neutrophilic airway inflammation. Animals used were six heaves-affected horses and five controls. Large peripheral lung biopsies were obtained from horses with heaves in clinical remission (Baseline) and during disease exacerbation and from age-matched controls. The area of collagen and elastic fiber content in the lamina propria was measured by histological staining techniques and corrected for airway size. Collagen type 1 and type 3 content was further assessed from additional horses after postmortem lung samples by immunohistochemistry. The collagen breakdown products proline-glycine-proline (PGP) and N-acetylated-PGP (N-α-PGP) were also measured in bronchoalveolar lavage fluids (BALF) by mass spectrometry. Compared with controls, heaves-affected horses had an increase in collagen (P = 0.05) and elastic fiber contents (P = 0.04) at baseline. Collagen types 1 and 3 content was also significantly increased in diseased horses (P = 0.015) when both collagen types were combined. No further change in collagen content was observed after a 30-day antigenic challenge. Airway collagen at baseline was positively correlated with pulmonary resistance in asthmatic horses (r(2) = 0.78, P = 0.03) and elastic fiber content was positively associated with pulmonary elastance in controls (r(2) = 0.95, P = 0.02). No difference between groups was appreciated in PGP and N-α-PGP peptides in BALF. Increased airway wall collagen and elastic fiber content may contribute to residual obstruction in the asthmatic airways.

show abstract

Extracellular matrix in airway smooth muscle is associated with dynamics of airway function in asthma

Abstract: In asthma, ECM in ASM is related to the dynamics of airway function in the absence of differences in ECM expression between asthma and controls. This indicates that the ASM layer in its full composition is a major structural component in determining variable airways obstruction in asthma.

Cited by 40 publications

References 34 publications

Key roles for the small leucine-rich proteoglycans in renal and pulmonary pathophysiology

Key roles for the small leucine-rich proteoglycans in renal and pulmonary pathophysiology

Glucocorticoid-induced Changes in Gene Expression of Airway Smooth Muscle in Patients with Asthma

Airway collagen and elastic fiber content correlates with lung function in equine heaves

Contact Info

Product

Resources

About