Extracellular Matrix Changes in Urethral Stricture Disease

Abstract

Composition changes in GAGs in strictured urethras could contribute to the noncompliant nature of urethral scar tissue and cause functional changes. These results may be useful for defining new targets for therapy for urethral stricture disease.

Histopathological Characteristics of Buccal Mucosa Transplants in Humans after Engraftment to the Urethra: A Prospective Study

“…We also did not biochemically analyze the extracellular matrix composition of integrated buccal mucosa transplants. Thus, although this was previously found to be a relevant etiological factor for urethral stricture disease, 26,27 we cannot exclude changes in extracellular matrix composition. We also could not retrieve specimens of buccal mucosa transplants from patients after successful urethroplasty.…”

The Effects of Hyaluronic Acid and Carboxymethylcellulose in Preventing Recurrence of Urethral Stricture After Endoscopic Internal Urethrotomy: A Multicenter, Randomized Controlled, Single-Blinded Study

“…The obstructive IPSS subscores were 1.56 -1. 18 = 0.138). However, the two groups did not differ significantly in terms of total IPSS scores at V1, V2, or V3 (Fig.…”

Assessment of the efficacy of absorbable adhesion barriers on dissection in esophagus operations

“…Assessment of Hydroxyproline tissue level, an indicator of total amount of collagen in the tissue has been used in several studies in order to show the structure developing in the tissue [12,13]. The purpose of this study is to investigate the efficacy of adhesion barriers histopathologically and biochemically during esophagus dissection.…”