Assessment of the efficacy of absorbable adhesion barriers on dissection in esophagus operations

Yılmaz, Ömer; Genç, Abdülkadir; Taneli, Fatma; Demireli, Peyker; Deliaga, Hasan; Taneli, Can

doi:10.1016/j.ijporl.2006.11.010

Cited by 4 publications

(4 citation statements)

References 31 publications

(33 reference statements)

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“…There was no increase in inflammation in the areas of Seprafilm application. A preclinical study in rats was unable to identify a benefit or detriment when the esophagus was wrapped with Seprafilm or Interceed, as assessed by adhesion score 3 weeks later or by hyroxyproline levels [66]. …”

Section: Seprafilm Adhesion Barriermentioning

confidence: 99%

Seprafilm® adhesion barrier: (1) a review of preclinical, animal, and human investigational studies

et al. 2012

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The aim of this study was to provide a single site resource for investigators, clinicians, and others seeking preclinical, animal, and human investigational studies concerning the postsurgical, anti-adhesion barrier Seprafilm™ (Genzyme Corporation, Cambridge, MA). All published preclinical, animal, human extra-abdominal research as of July 2011 have been summarized and included in this document. Searches of Medline and EMBASE Drugs and Pharmaceuticals databases were conducted for original preclinical, animal, and human extra-abdominal studies involving Seprafilm. Preclinical, animal, and extra-abdominal human investigational studies are the study selection for this manuscript. Intraabdominal use is discussed in the accompanying manuscript. Data extraction includes systematic manuscript review. Summary of preclinical, animal, and extra-abdominal human investigational use of Seprafilm by surgical discipline were gathered for data synthesis. The clinical use of Seprafilm, which was approved by the FDA for intra-abdominal procedures, is supported by preclinical and animal studies relating to general surgical and obstetrical/gynecological applications. Findings from preclinical, animal, and human investigational studies at other sites throughout the body raises the potential for additional human clinical trials to assess efficacy and safety following surgical procedures at non-abdominal locations.

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Section: Seprafilm Adhesion Barriermentioning

confidence: 99%

Seprafilm® adhesion barrier: (1) a review of preclinical, animal, and human investigational studies

et al. 2012

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“…An animal study showed that Interceed and Seprafilm (Genzyme Co., Cambridge, MA, USA) effectively prevent adhesion in subtotal thyroidectomy. In the other study, although Seprafilm had the best mean score, this was statistically insignificant and Seprafilm and Interceed had no effect on esophagus dissection [12]. …”

Section: Discussionmentioning

confidence: 99%

“…1). Recently, a number of researchers have suggested the use of anti-adhesive agents for preventing postoperative adhesion of the cervical area after thyroid or neck surgery [9-12]. …”

Section: Introductionmentioning

confidence: 99%

Antiadhesive effect and safety of oxidized regenerated cellulose after thyroidectomy: a prospective, randomized controlled study

Park

Lee

et al. 2013

J Korean Surg Soc

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PurposeTo evaluate the antiadhesive effects and safety of an oxidized regenerated cellulose (Interceed) after thyroidectomy.MethodsSeventy-six thyroidectomized patients were prospectively randomized into two groups with regard to the use of Interceed. We evaluated each group for their adhesive symptoms using four subjective and four objective items at the 2nd week, 3rd and 6th month after thyroidectomy. All patients were examined for vocal cord motility by indirect laryngoscope at each period.ResultsTotal adhesion scores at each postoperative follow-up period decreased with time, but were not significantly different in each group. The median score for swallowing discomfort for liquid was significantly lower in the Interceed group than in the control group 2 weeks after surgery. In addition, the severity of skin adhesion to the trachea was reduced in the Interceed group compared with the control group 6 months after surgery. During the study, there were no adverse effects or significant differences in postoperative complications between the groups.ConclusionInterceed appeared to be safe and effective in improving neck discomfort at early postoperative periods and preventing skin adhesion to the trachea 6 months after thyroidectomy.

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“…Interceed представляет собой раствор окисленной восстанов-ленной целлюлозы, а Seprafilm является комбини-рованным препаратом из гиалуроновой кислоты и карбоксиметилцеллюлозы, производимым в виде мембраны. Оба средства характеризуются нетоксич-ностью, неиммуногенностью и биосовместимостью [28][29][30][31]. O. Yigit и соавт.…”

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On the issue of adhesions after noncomplicated thyroidectomy and application of antiadhesive medications in thyroid surgery

Курганов¹,

Bogdanov²,

Лукьянченко³

et al. 2015

Endosk. khir.

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Assessment of the efficacy of absorbable adhesion barriers on dissection in esophagus operations

Cited by 4 publications

References 31 publications

Seprafilm® adhesion barrier: (1) a review of preclinical, animal, and human investigational studies

Seprafilm® adhesion barrier: (1) a review of preclinical, animal, and human investigational studies

Antiadhesive effect and safety of oxidized regenerated cellulose after thyroidectomy: a prospective, randomized controlled study

On the issue of adhesions after noncomplicated thyroidectomy and application of antiadhesive medications in thyroid surgery

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