Antiadhesive effect and safety of oxidized regenerated cellulose after thyroidectomy: a prospective, randomized controlled study

Abstract

PurposeTo evaluate the antiadhesive effects and safety of an oxidized regenerated cellulose (Interceed) after thyroidectomy.MethodsSeventy-six thyroidectomized patients were prospectively randomized into two groups with regard to the use of Interceed. We evaluated each group for their adhesive symptoms using four subjective and four objective items at the 2nd week, 3rd and 6th month after thyroidectomy. All patients were examined for vocal cord motility by indirect laryngoscope at each period.ResultsTotal adhesion scores at each postoperative follow-up period decreased with time, but were not significantly different in each group. The median score for swallowing discomfort for liquid was significantly lower in the Interceed group than in the control group 2 weeks after surgery. In addition, the severity of skin adhesion to the trachea was reduced in the Interceed group compared with the control group 6 months after surgery. During the study, there were no adverse effects or significant differences in postoperative complications between the groups.ConclusionInterceed appeared to be safe and effective in improving neck discomfort at early postoperative periods and preventing skin adhesion to the trachea 6 months after thyroidectomy.

Swallowing disorders after thyroidectomy: What we know and where we are. A systematic review

“…The advantages of the subfascial approach to thyroidectomy in reducing the hyoid fixation confirm these findings [18]. Assuming that the adhesions between the different neck structures (laryngotracheal unit, strap muscles, platysma, skin flap) could influence the swallowing, some antiadhesive dressings have been used between the different layers, but the results are conflicting [19,20].…”

Network meta-analysis of topical haemostatic agents in thyroid surgery

“…After removing duplicates, 569 potentially eligible titles and abstracts were identified. Overall, thirteen RCTs were included in the meta‐analysis. Eight potentially relevant full texts were excluded ( Fig .…”

“…An important difference to note between the trials was the extent to which anticoagulated patients were included. Whereas one trial focused specifically on anticoagulated patients, such patients were excluded explicitly from four trials, and no information on the use of anticoagulants was provided in the remaining eight trials.…”

On the issue of adhesions after noncomplicated thyroidectomy and application of antiadhesive medications in thyroid surgery

“…Суще-ствует гипотеза, что образование спаек и разраста-ние соединительной ткани после операции вокруг пищевода и гортани могут ограничивать их подвиж-ность, нарушая нормальную моторную функцию. Также указывается на то, что внутренние сращения влияют и на косметический результат оперативного вмешательства, делая кожный рубец более замет-ным [9][10][11].…”

“…Например, K. Park и соавт. [9] изучали вли-яние антиадгезивного средства Interceed на течение послеоперационного периода у пациентов, пере-несших тотальную тиреоидэктомию. В большин-стве случаев операция была проведена по поводу злокачественного образования и сопровождалась лимфодиссекцией.…”