Extracellular fluid volume and glomerular filtration rate

Peters, A. M.; Glass, D.; Bird, Nicholas J.

doi:10.1097/mnm.0b013e3283457466

Cited by 14 publications

(5 citation statements)

References 15 publications

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“…An increase in ECFV can occur in end stage renal disease in human patients and ECFV increases in the early stages of CKD by approximately 8% 23. Human patients show a progressive increase in ECFV with declining GFR,23, 24 although there is no correlation between GFR and ECFV in human patients across a range of GFR 25. In this study, there was no significant difference in ECFV between nonazotemic and azotemic cats.…”

Section: Discussioncontrasting

confidence: 52%

Determination of Extracellular Fluid Volume in Healthy and Azotemic Cats

Finch

Heiene

Elliott

et al. 2014

Veterinary Internal Medicne

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BackgroundMethods for determining extracellular fluid volume (ECFV) are important clinically for cats. Bromide dilution has been studied in cats to estimate ECFV. Markers of GFR also distribute in ECFV and can be used for its measurement.Hypothesis/ObjectivesThe primary objective was to develop a method of determining ECFV from iohexol clearance in cats and evaluate agreement with that determined using bromide dilution. Additional objectives were to compare ECFV between azotemic and nonazotemic cats and evaluate appropriate methods of standardizing ECFV.AnimalsClient‐owned cats with varying renal function.MethodsValidation of ECFV determined from slope‐intercept iohexol clearance was performed in 18 healthy nonazotemic cats. ECFV was then determined using the validated method and bromide dilution and agreement assessed. Appropriateness of standardization to body weight (BW) and body surface area (BSA) was evaluated.ResultsExtracellular fluid volume determined from slope‐intercept iohexol clearance and bromide dilution was 0.84 ± 0.32 L and 0.85 ± 0.19 L (mean ± SD), respectively. There were wide limits of agreement between the methods (−0.58 to 0.54 L) and therefore, agreement was considered to be poor. ECFV did not differ significantly between azotemic and nonazotemic cats (P = .177). BSA was found to be the best method for standardizing ECFV measurement in cats.Conclusions and Clinical ImportanceThis study developed a method for determining ECFV from slope‐intercept iohexol clearance which provides simultaneous assessment of renal function and an estimate of ECFV. ECFV does not differ between azotemic and nonazotemic cats, which suggests fluid volume loss or overload is not an important clinical feature in cats with mild chronic kidney disease.

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Section: Discussioncontrasting

confidence: 52%

Determination of Extracellular Fluid Volume in Healthy and Azotemic Cats

Finch

Heiene

Elliott

et al. 2014

Veterinary Internal Medicne

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“…GFR can be determined by measuring renal clearance of an intrinsic or extrinsic agent that is freely filtered by the glomeruli (6,7). Inulin clearance has been widely believed to be the gold standard for GFR studies, but it is relatively invasive and not easy to perform in everyday practice (8). Measurement of Tc-99m diethylenetriamine pentaacetic acid (Tc-99m DTPA) plasma clearance is used by many institutions for the determination of total GFR due to its simplicity and precision (9)(10)(11)(12).…”

Section: Introductionmentioning

confidence: 99%

Comparison of glomerular filtration rate measurements with the two-plasma sample technique using Tc-99m DTPA and other methods in donor candidates for renal transplantation

et al. 2016

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Background/aim: Accurate measurement of glomerular filtration rate (GFR) in the evaluation of renal functions in potential kidney donors is associated with important outcomes for both the donor and recipient. We intended to determine the efficacy of various methods while estimating GFR in potential living kidney donors.Materials and methods: Fifty-three potential kidney donors (31 females, 22 males; mean age: 50.1 years) were included in this study. GFR was estimated simultaneously using the following methods: Gates' method, Cockcroft-Gault (CG) and modification of diet in renal disease (MDRD) prediction equations, and the two-plasma sample (TPS) technique. Using TPS as the reference method, the estimations of GFR with the other methods were compared with that of TPS.

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“…Earlier inulin clearance used to be considered the gold standard for GFR studies, but it is relatively invasive and not easy to perform in routine clinical practice. [5] Currently, estimation of Tc-99m diethylenetriaminepentaacetic acid ( 99m Tc-DTPA) plasma clearance is used for the determination of global GFR due to its simplicity and precision. [6789] It is also reported that there is a correlation between 99m Tc-DTPA and inulin clearances when measuring GFR in clinical applications.…”

Section: Introductionmentioning

confidence: 99%

Comparison between two-sample method with ^99mTc-diethylenetriaminepentaacetic acid, Gates' method and estimated glomerular filtration rate values by formula based methods in healthy kidney donor population

et al. 2017

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Purpose of the Study:Glomerular filtration rate (GFR) is the most important parameter for the assessment of renal function. GFR by plasma sampling technique is considered accurate in the selection of donors for renal transplantation. Estimated GFR (eGFR) calculations using Gates’ method and Modification of Diet in Renal Disease (MDRD) and Cockcroft–Gault (CG) equations are simple methods but have not been validated in the Indian population. Hence, we aimed to assess the correlation between these three techniques.Materials and Methods:The plasma sampling technique was done using two samples at 60 and 180 min after injection of 1 mCi (37MBq) 99mTc-diethylenetriaminepentaacetic acid (99mTc-DTPA) in 66 healthy donors. Age, sex, height, weight, and plasma creatinine were recorded. Normalized GFR (nGFR) by two-sample method and eGFR (for Gates’, MDRD, and CG) values were calculated using formulae.Results:There were 14 male and 52 female donors. Mean age was 46.56 ± 12.88 years (24–69 years). Mean height was 153.74 ± 8.35 cm, whereas mean weight was 56.97 ± 11.88 kg. Mean nGFR value was 80.4 for two-sample method while mean eGFR value for Gates’, CG, and MDRD were 83.3, 89.36, and 97.47 ml/min/1.73 m2 (eligibility value at our institution = 70), respectively. While the correlation between nGFR and eGFR CG and MDRD was weak moderate (correlation coefficient = 0.5), nGFR and eGFR Gates’ had a moderate correlation (0.686). Mean total bias for eGFR Gates’, CG, and MDRD were 2.87, 8.93, and 17.0, respectively. P30 of eGFR Gates’, CG and MDRD were 60.6%, 57.6%, and 62.1%, respectively.Conclusions:Due to the large variability in eGFR Gates’, CG and MDRD, nGFR estimation using the plasma sampling technique with 99mTc-DTPA appears necessary while screening healthy donors for renal transplantation.

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Extracellular fluid volume and glomerular filtration rate

Abstract: In unselected patient populations, there is no correlation between GFR and ECV. The CV of ECV is slightly higher in patients than healthy individuals but, in both, is less than the CV of GFR. These data do not detract from the use of slope-only GFR.

Cited by 14 publications

References 15 publications

Determination of Extracellular Fluid Volume in Healthy and Azotemic Cats

Determination of Extracellular Fluid Volume in Healthy and Azotemic Cats

Comparison of glomerular filtration rate measurements with the two-plasma sample technique using Tc-99m DTPA and other methods in donor candidates for renal transplantation

Comparison between two-sample method with ^99mTc-diethylenetriaminepentaacetic acid, Gates' method and estimated glomerular filtration rate values by formula based methods in healthy kidney donor population

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Extracellular fluid volume and glomerular filtration rate

Abstract: In unselected patient populations, there is no correlation between GFR and ECV. The CV of ECV is slightly higher in patients than healthy individuals but, in both, is less than the CV of GFR. These data do not detract from the use of slope-only GFR.

Cited by 14 publications

References 15 publications

Determination of Extracellular Fluid Volume in Healthy and Azotemic Cats

Determination of Extracellular Fluid Volume in Healthy and Azotemic Cats

Comparison of glomerular filtration rate measurements with the two-plasma sample technique using Tc-99m DTPA and other methods in donor candidates for renal transplantation

Comparison between two-sample method with 99mTc-diethylenetriaminepentaacetic acid, Gates' method and estimated glomerular filtration rate values by formula based methods in healthy kidney donor population

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Comparison between two-sample method with ^99mTc-diethylenetriaminepentaacetic acid, Gates' method and estimated glomerular filtration rate values by formula based methods in healthy kidney donor population