Extracellular and intracellular magnesium concentrations in asthmatic patients

Valk, HW de; Kok, PT; Struyvenberg, A; Rijn, HJ van; Haalboom,; Kreukniet, J; Lammers, J.-W. J.

doi:10.1183/09031936.93.06081122

Cited by 26 publications

(1 citation statement)

References 8 publications

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“…Studies in adults report low serum magnesium levels [21]. However, in our study, asthmatic children had normal serum magnesium levels, as reported in some studies [22]; magnesium is mainly an intracellular ion, and normal serum Mg levels may not reflect intracellular magnesium deficiency. Therefore, the estimation of intracellular magnesium concentration may be more accurate [23].…”

Section: Discussionsupporting

confidence: 53%

Low Serum Levels of Zinc, Selenium, and Vitamin D3 Are Biomarkers of Airway Inflammation and Poor Asthma Control: A Two-Centre Study

Srivastava¹,

Tiwari²,

Singh³

et al. 2023

Cureus

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BackgroundAsthma is a chronic inflammatory disease with its control being affected by underlying oxidative stress. Trace elements, along with vitamin D3, play an important role in immune alterations leading to an imbalance of Th1/Th2 helper cells. However, their role in asthma pathogenesis and control is inconsistent and inconclusive. The objective of our study was to assess levels of serum trace elements like zinc, copper, selenium, iron, magnesium, vitamin D3 levels, IgE, and HsCRP in asthmatic children, compare with healthy controls, and assess their association with the level of asthma control. MethodsA cross-sectional study was conducted from 2019 to 2021 enrolling 100 asthmatic children and 75 healthy controls. The level of asthma control was assessed as uncontrolled, partly controlled, and controlled asthma as per GINA Guidelines. Mean and standard deviation were calculated for each element and mean differences between groups were analyzed by student t-test. A p-value of <0.05 was considered significant. ResultsThe mean age was 8.75±2.89 yrs in cases and 9.04±2.79 in controls. A total of 57.6% of cases had atopic comorbidities. The mean serum zinc levels were 51±12.8 mg/dl, which was very low in asthmatic children as compared to 60±18.2mg/dl (p-value 0.0002) in healthy controls. Serum selenium was 13±3 µg/dl in asthmatics vs. 15±4 µg/dl (p-value 0.0002) in healthy controls. Serum copper was 115.2±21.92µg/dl vs. 125.3±31.99µg/dl (p-value 0.015), Serum vitamin D3 levels were 13.07±7.82ng/ml vs. 17.82±14.62 ng/ml(pvalue 0.006) in both groups, respectively. SIgE and HsCRP were high in asthmatic children suggestive of eosinophilic inflammation. Serum zinc was 49±5.45 mg/dl in the uncontrolled group, 53±6.1 in the partly controlled, and 58±8.0 in the well-controlled group (p<0.0001). Serum selenium was 10± 3.0 µg/dl in the uncontrolled group vs. 13± 2.0 and 14± 2.0 µg/dl in the partly controlled and well-controlled groups, respectively (p-value <0.0001). Vitamin D3 was significantly low (9.32±5.95ng/dl) in the uncontrolled group vs. 12.99±4.97 and 13.40±5.92 ng/dl(p<0.005) in the partly controlled and well-controlled groups respectively. Vitamin D3 showed a strong positive correlation with zinc (r=0.4,p< 0.0001) and a negative correlation with inflammatory markers like SIgE and HsCRP. ConclusionChildren with asthma had low zinc, selenium, and vitamin D3 levels, and were associated with airway inflammation and poor asthma control.

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Section: Discussionsupporting

confidence: 53%

Low Serum Levels of Zinc, Selenium, and Vitamin D3 Are Biomarkers of Airway Inflammation and Poor Asthma Control: A Two-Centre Study

Srivastava¹,

Tiwari²,

Singh³

et al. 2023

Cureus

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Magnesium and calcium in exhaled breath condensate of children with asthma and gastroesophageal reflux disease

Dodig

Vlašić

Čepelak

et al. 2009

Clinical Laboratory Analysis

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Background: Magnesium and calcium physiologic functions are closely related. Magnesium is primarily an intracellular cation, the action of which also involves maintenance of cellular ionic balance, while influencing calcium homeostasis by blocking calcium channels. The aim of this study was to compare the concentrations of magnesium and calcium in exhaled breath condensate (EBC) of children with asthma and gastroesophageal reflux disease (GERD).Subjects and methods: EBC was collected from 66 children aged 7–14 years (23 children with acute asthma, 17 children with GERD, and 26 healthy children).Determination of magnesium and calciumconcentrations was preceded by optimization and validation for low concentrations.Results: No difference was recorded for either magnesium or calcium concentration between study groups. However, the magnesium to calcium ratio was statistically significantly lower in both GERD and asthma children as compared with control group.Conclusion: Study results showed the magnesium to calcium ratio to be a statistically significantly better indicator of certain pathologic changes than absolute concentration of either ion. J. Clin. Lab. Anal. 23:34–39, 2009. © 2009 Wiley‐Liss, Inc.

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Magnesium Links to Asthma Control

Kazaks

2012

Magnesium in Human Health and Disease

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Extracellular and intracellular magnesium concentrations in asthmatic patients

Cited by 26 publications

References 8 publications

Low Serum Levels of Zinc, Selenium, and Vitamin D3 Are Biomarkers of Airway Inflammation and Poor Asthma Control: A Two-Centre Study

Low Serum Levels of Zinc, Selenium, and Vitamin D3 Are Biomarkers of Airway Inflammation and Poor Asthma Control: A Two-Centre Study

Magnesium and calcium in exhaled breath condensate of children with asthma and gastroesophageal reflux disease

Magnesium Links to Asthma Control

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