Extracapillary glomerulonephritis and renal amyloidosis

Moroni, Gabriella; Banfi, Giovanni; Maccario, Massimo; Mereghetti, Marco; Ponticelli, Claudio

doi:10.1016/s0272-6386(96)90250-4

Cited by 20 publications

(13 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Therefore, we believe that interstitial and blood vessel damages have some influence on arterial blood pressure; blood vessels with amyloid depositions exhibit a functional dilatation. While renal amyloidosis is known to cause crescent formation [22], such cases were excluded from the present study.…”

Section: Discussionmentioning

confidence: 99%

Prognosis of Renal Amyloidosis: A Clinicopathological Study Using Cluster Analysis

Sasatomi

Kiyoshi²,

Uesugi³

et al. 2001

Nephron

View full text Add to dashboard Cite

Progression of renal amyloidosis is associated with severe proteinuria or nephrotic syndrome, and various mechanisms have been postulated to explain these complications. We studied the acceleration of proteinuria and reduced renal function by cluster analysis using clinical parameters, renal histological findings, type of renal amyloidosis and follow-up data. We divided 97 cases into three groups of renal amyloidosis. Accelerated progression correlated with serum creatinine (s-Cr) levels at renal biopsy and histological grade of renal damage by amyloid deposition (p < 0.0001). The most influential prognostic factors (s-Cr level ≧2.0 mg/dl) were tubulointerstitial and vascular damage induced by amyloid deposition at biopsy (odds ratio 96.9 and 69.2, respectively). In addition, we found amyloidosis type amyloid associated (AA) correlated with more amyloid-mediated vascular and tubulointerstitial damage than amyloidosis type amyloid light chain (AL) (p < 0.001, p < 0.01, respectively). Proteinuria and nephrotic syndrome were more severe in cases of amyloidosis AL than in amyloidosis AA (p = 0.076). In conclusion, less tubulointerstitial and vascular damage was caused by amyloid deposition; this was slowly progressive. Amyloid AA was detected in tubulointerstitial tissue and vessels more frequently than amyloid AL. Heavy proteinuria and/or nephrosis were not indicators of rapid progression.

show abstract

Section: Discussionmentioning

confidence: 99%

Prognosis of Renal Amyloidosis: A Clinicopathological Study Using Cluster Analysis

Sasatomi

Kiyoshi²,

Uesugi³

et al. 2001

Nephron

View full text Add to dashboard Cite

show abstract

“…These are virtually exclusively cases of AA amyloidosis that also feature glomerular extracapillary proliferation, a hallmark of crescentic glomerulonephritis [10], mostly in patients with florid rheumatoid arthritis [11, 12, 13, 14, 15, 16]. In these cases, the mechanism of glomerular injury is thought to involve basement membrane rupture and mesangial cell dysfunction due to amyloid-fibril deposition, leading to leakage of proteinaceous material and cellular contents into Bowman’s space, thereby initiating glomerular crescent formation [13].…”

Section: Discussionmentioning

confidence: 99%

Atypical case of AL amyloidosis with urinary erythrocyte casts

Liangos

Buettner-Herold

Ketteler

et al. 2015

CNCS

View full text Add to dashboard Cite

We present the case of a 73-year-old man who developed an acute, severe febrile illness with multiorgan dysfunction, featuring renal failure, nephrotic-range proteinuria, microhematuria, and a skin rash. Numerous erythrocyte casts were found on urine microscopy. Typically, the finding of urinary erythrocyte casts indicates the presence of an underlying glomerular inflammatory disease. However, on renal biopsy, only amyloid light-chain (AL) amyloidosis and tubular injury were the predominant findings with no signs of glomerular or vascular inflammation. Photomicrographs of urinary sediment as well as renal biopsy histopathology of the presented case are shown. The unusual combination of findings, is then discussed in light of the existing literature on renal amyloidosis as well as erythrocyte casts in conditions other than glomerulonephritis.

show abstract

“…[15] Moroni et al ., in their report of three cases of crescentic glomerulonephritis superimposed on amyloidosis, have documented partial recovery of renal functions in two patients after treatment with intravenous pulse methylprednisolone, immunosuppressive agents, and oral corticosteroids. [16]…”

Section: Discussionmentioning

confidence: 99%

Rapidly progressive glomerulonephritis in a patient with renal amyloidosis: Case report and review of the literature

Anupama¹,

Vankalakunti²

2012

Indian J Nephrol

View full text Add to dashboard Cite

Renal amyloidosis is characterized by progressive deposition of extracellular material, most commonly in the glomeruli. Most often, patients present with nephrotic range proteinuria and the disease progresses gradually to renal failure. Rapid worsening of renal functions is rare. We report a case of crescentic glomerulonephritis superimposed on amyloidosis, clinically presenting as rapidly progressive renal failure, and present a review of the literature.

show abstract

Extracapillary glomerulonephritis and renal amyloidosis

Cited by 20 publications

References 8 publications

Prognosis of Renal Amyloidosis: A Clinicopathological Study Using Cluster Analysis

Prognosis of Renal Amyloidosis: A Clinicopathological Study Using Cluster Analysis

Atypical case of AL amyloidosis with urinary erythrocyte casts

Rapidly progressive glomerulonephritis in a patient with renal amyloidosis: Case report and review of the literature

Contact Info

Product

Resources

About