Extraadrenal Myelolipoma: <i>A Report of Two Cases</i>

Hunter, Stephen B.; Schemankewitz, Erwin; Patterson, Cameron; Varma, Vijay

doi:10.1093/ajcp/97.3.402

Cited by 48 publications

(34 citation statements)

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“…They have been reported in the presacral region [2], mediastinum [3], retroperitoneum [4], liver [5], spleen [6], stomach [7], leptomeninges, and thoracic cavity including lung. To the best of our knowledge, only 8 cases of primary myelolipoma of the lung have been reported [8][9][10][11][12][13]. In the present paper, we report a case of pulmonary myelolipoma misdiagnosed as a malignant tumor before surgery.…”

Section: Introductionmentioning

confidence: 83%

“…The sites of extraadrenal myelolipoma have been described in the presacral soft tissue, retroperitoneum, pelvis, mesentery, spleen, liver, stomach, mediastinum, and leptomeninges [2][3][4][5][6][7]. Only eight cases of myelolipoma arising from the lung have been reported [8][9][10][11][12][13]. Of the previously reported cases, five of them were solitary, and two were multifocal.…”

Section: Discussionmentioning

confidence: 99%

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Primary myelolipoma of the lung: a case of report and review of literature

Huang¹,

Zhao²,

Yin³

et al. 2012

pjp

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Section: Introductionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Primary myelolipoma of the lung: a case of report and review of literature

Huang¹,

Zhao²,

Yin³

et al. 2012

pjp

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“…The exact pathogenesis of myelolipoma is not clear at present. Most theories involve the development and differentiation of either ectopic adrenal rests or hematopoietic stem cell rests in response to a triggering stimulus, particularly endocrine dysfunction [15]. Other researchers found clonal cytogenetic abnormalities, which suggested it was of neoplastic pathogenesis [16].…”

Section: Discussionmentioning

confidence: 99%

Myelolipoma: A Rare Adrenal Incidentaloma

Tiwari¹,

Halder²

2015

Surgery

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Case ReportOpen Access IntroductionMyelolipomas are rare, benign tumors composed of mature adipose tissue and hematopoietic elements (myeloid and erythroid cells) [1]. We describe a case of dual pathology where adrenal incidentaloma was successfully treated. Case ReportA 40-year-old lady was referred to surgical outpatient clinic with an ultrasonologically detected adrenal mass, while being investigated for menorrhagia with a large pelvic mass. She did not have any symptoms related to the adrenal mass and was normotensive. Further biochemical investigations directed to adrenal pathology revealed a normal urinary VMA level, serum electrolytes and cortisol levels. The initial ultrasound scan suggested a well-defined, hyperechoic SOL in the left suprarenal region (94 x 80 mm) suggestive of a lipomatous tumour, along with a large intrauterine fibroid (119 x 96 mm). Subsequently, CECT of the abdomen revealed a large, well defined, mildly & heterogeneously enhancing mass lesion showing attenuation value of fat, involving left adrenal gland, suggestive of myolipoma (Figures 1 and 2). The right suprarenal was normal. In view of the large size of the uterine tumour and the fact that menorrhagia was under control, she underwent left adrenalectomy only in the first sitting, through a modified chevron incision. Macroscopical cut section of the specimen showed homogenous yellow surface with reddish streaking. Histopathology of the specimen revealed features of myelolipoma. She had an uneventful recovery and doing well now at six months follow up. Discussion and ConclusionEdgar von Gierke first described this lesion in the adrenal in 1905 but it was named, "myelolipoma", by Charles Oberling [2,3]. The adrenal gland is the most common site, but myelolipomas also (rarely) occur in extra-adrenal sites (14% of myelolipomas are extraadrenal [4]) including the pelvis, mediastinum, retroperitoneum, and paravertebral region, as an isolated soft tissue mass [5].It is usually hormonally inactive, and found in 0.08 to 0.2% of autopsy series [6,7] but comprise up to 15% of adrenal incidentalomas with the increasing use of noninvasive imaging [8] and account for 2.6% of all primary adrenal tumours [9]. Myelolipomas, affect both sexes equally and usually occur during fifth and seventh decades of life [10]. Adrenal myelolipomas are in the majority of cases unilateral. However, they can also be bilateral [11]. Adrenal myelolipomas may be found coincidentally with other lesions in the adrenal glands, such as adenomas and less commonly with pheochromocytoma or metastases. These cases are described as "collision tumours" [12].Adrenal myelolipomas vary in size, from several millimetres to more than 30 cm, and usually in the range of 2-10 cm in diameter [1,13]. The term giant myelolipoma is preferred when the size exceeds 8 cm [14], as seen in our case. AbstractBackground: Myelolipoma is a rarely encountered, adrenal incidentaloma diagnosed on the basis of its radiological features.Aim: To describe a rare presentation with dual pathology.Case p...

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“…They are predomi nantly composed of hematopoietic elements, erythroid predominance and lack of lymphoid aggregates. In con trast, myelolipoma is a well-circumscribed single mass and composed of adipose tissue and hematopoietic ele ments with lymphoid aggregates or follicle formation [41].…”

Section: Discussionmentioning

confidence: 99%

Symptomatic Adrenal Myelolipoma

Sharma¹,

Kashyap²,

Sharma³

et al. 1997

Urol Int

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Seven cases of adrenal myelolipoma comprising 5.8% of total adrenal tumors are described with a male-to-female ratio of 1.3:1. Five were symptomatic, of which 4 had a palpable abdominal mass, 2 cases detected incidentally were associated with carcinoma of the uterine cervix and renal cell carcinoma, respectively. The average age and duration of symptoms at presentation were 56 years (range 38–70 years) and 3.16 months (range 1–9 months). A CT scan was done in all cases, of which 5 showed a nonenhancing mass lesion with fat density diagnosed as adrenal myelolipoma. However, in 1 case radiological diagnosis of liposarcoma was maintained because of the huge size of the lesion whereas in another case the lesion was missed because of associated renal cell carcinoma. Interestingly the right adrenal was involved in all cases and the weight varied from 7 to 2,000 g. No recurrence was noted in the follow-up period (ranging from 3 months to 10 years).

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Extraadrenal Myelolipoma: A Report of Two Cases

Cited by 48 publications

References 0 publications

Primary myelolipoma of the lung: a case of report and review of literature

Primary myelolipoma of the lung: a case of report and review of literature

Myelolipoma: A Rare Adrenal Incidentaloma

Symptomatic Adrenal Myelolipoma

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