Extra virgin olive oil enhances the hepatic antioxidant defense and inhibits cytogenotoxic effects evoked by 5-hydroxymethylfurfural in mice

Bohi, Khlood M. El; Ghoniem, Mervat H.; Azab, Haidy H.; Ali, Haytham; Farag, Mayada R.

doi:10.1007/s11356-020-07659-x

Cited by 8 publications

(9 citation statements)

References 46 publications

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“…Many previous studies have demonstrated that excess ROS can cause oxidative stress and mitochondrial dysfunction, subsequently initiating cellular apoptosis. El Bohi et al 21 found that a natural antioxidant reduced HMF-triggered apoptosis in hepatocytes, which may be related to radical scavenging. We then analyzed whether ROS production affects the mitochondrial apoptotic pathway by examining the MMP and the mRNA expressions of Bcl-2 and Bax.…”

Section: ■ Materials and Methodsmentioning

confidence: 99%

“…18 Several lines of evidence have indicated that the toxicity of 5-HMF is directly related to the formation of reactive oxygen species (ROS) or a decrease in antioxidant defenses, 19,20 which leads to long-term accumulation of oxidative lesions in mammalian cells. 21 Moreover, severe oxidative damage can trigger the signaling cascades involved in apoptosis. 22 Based on these findings, we speculate that 5-HMF can evoke an oxidant−antioxidant imbalance and consequently induce gastric epithelial cells to undergo cell death by apoptosis.…”

Section: ■ Introductionmentioning

confidence: 99%

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5-Hydroxymethylfurfural Exerts Negative Effects on Gastric Mucosal Epithelial Cells by Inducing Oxidative Stress, Apoptosis, and Tight Junction Disruption

Qiu

Lin

Chen

et al. 2022

J. Agric. Food Chem.

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5-Hydroxymethylfurfural (5-HMF) is a processing byproduct present in foods that are consumed daily by humans, and the diet is the principal route for human exposure to it. However, its adverse effects on gastric epithelial cells are not fully understood. Based on the half inhibitory concentration value, concentrations of HMF of 2, 4, 8, and 16 mM were selected for this study. After 5-HMF treatment for 24 h, the number of living cells decreased to 89.61 ± 0.48, 77.30 ± 0.57, 58.75 ± 0.36, and 19.61 ± 0.40% of the control, respectively. Apoptosis activated through both the death receptor and mitochondrial pathways was confirmed to be the primary mode of HMF-induced cell death. Further analysis revealed that the reactive oxygen species (ROS) levels in GES-1 cells increased 1.7–6.5 fold after exposure to 5-HMF. Moreover, the inhibition of ROS by N-acetylcysteine blocked HMF-induced apoptosis and cell proliferation suppression, indicating that oxidative stress was important in HMF-induced apoptosis. Besides, after 5-HMF treatment, the gene expressions of occludin and ZO-1 were reduced by 1.1–3.4 fold and 2.0–9.4 fold, respectively. The cell surface morphology and tight junction-related protein expression analysis also revealed the destructive effect of 5-HMF on tight junction integrity. Our research highlights a potential mechanism of HMF-induced toxicity in GES-1 cells and provides additional information on the health risks of 5-HMF exposure to the human gastric epithelium.

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Section: ■ Materials and Methodsmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

5-Hydroxymethylfurfural Exerts Negative Effects on Gastric Mucosal Epithelial Cells by Inducing Oxidative Stress, Apoptosis, and Tight Junction Disruption

Qiu

Lin

Chen

et al. 2022

J. Agric. Food Chem.

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“…El Bohi et al, stated that administration of EVOO alone or with 5-HMF reduced hepatotoxicity of 5-HMF and implemented an antioxidant defense system, liver function biomarkers, and histoarchitecture of the liver. EVOO also inhibited the genotoxic and apoptotic effects of 5-HMF [43].…”

Section: Discussionmentioning

confidence: 87%

“…EVOO decreased ALT, AST activities and restored them towards normal values via preservation of functional integrity of hepatic cell membrane due to olive oil's ability to scavenge free radicals [43]. El Bohi et al, stated that administration of EVOO alone or with 5-HMF reduced hepatotoxicity of 5-HMF and implemented an antioxidant defense system, liver function biomarkers, and histoarchitecture of the liver.…”

Section: Discussionmentioning

confidence: 99%

The Enhanced Beneficial Effect of Extra Virgin Olive Oil Over Evening Primrose Oil on Oxidative Stress, and Liver Function in Male Arthritic Rats

Kandeil

Ebrahim

Mahmoud

2021

JPRI

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Aims: Rheumatoid arthritis (RA) is characterized by the onset of oxidative stress. This study aimed to evaluate the enhancing of extra virgin olive (EVOO) and Evening primrose oil (EPO) on oxidative stress and liver enzymes in male Wistar rats and compare between them. Place and Duration: Faculty of Science biochemistry department, Between July 2018 and August 2018. Methodology: A Subcutaneous injection of 200 µl of Freund's complete adjuvant into a footpad of the right hind leg of Wistar male rats at two consecutive days induced RA. Rats received EVOO and EPO daily by oral gavage needle with gauge 18 at doses of 5 mg/kg b.wt./day. for 10 and 21 days. No loss was recorded in the experimental rats. Results: A significant depletion in serum Reduced glutathione content (GSH), glutathione peroxidase (GPX), and glutathione s transferase activities (GST) in arthritic rats compared to normal rats after 10 and 21 days of induction which improved significantly after 10 and 21 days of EPO and EVOO treatments. EPO and EVOO treatments for 21 days increased the GSH and GPX compared to 10 days treatments while no difference in GST activity. EVOO treatment improved GSH and GPX after 10 and 21 days than EPO treatment. The elevated uric acid levels in arthritic rats were markedly ameliorated as a result of EVOO and EPO treatment administration. Increased lipid peroxidation products (MDA), rheumatoid factor, and liver enzyme (Alanine transaminase ALT and Aspartate transaminase AST) were recorded in arthritic rats and they significantly progressed after EPO and EVOO treatments for 10 and 21 days but EVOO had the best effect at 21 days. Conclusion: EVOO and EPO showed significant antioxidant efficacies and improved affected liver enzymes due to rheumatoid arthritis onset. When comparing olive oil has more antioxidant properties than evening primrose oil, so we recommend more studies on olive oil combination with anti-arthritic medications to improve their efficacies with less toxicity.

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“…on the other hand, Histopathological effect of Cefotaxime on renal tissues was also markedly improved by co-administration of olive oil and cefotaxime. all this illustrated in Figure (11,12,13,14)…”

Section: Histopathological Findingmentioning

confidence: 84%

Amelorative effect of olive oil against hepatorenal toxicity of cefotaxime in albino rats

Elkomy

Elsayed

sayed

et al. 2020

IJPT

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Due to great hazard effects of antibiotic the following study aimed to investigate the adverse effect of cefotaxime in biochemical, oxidative status and histological examination of Liver and kidney tissue as well as the protective effect of olive oil. Twenty four male Wister albino rats were randomly divided into main four groups including: - G (1): Served as control group and it includes six rats, they were administrated 0.5ml of saline orally for 14 consecutive days. G (2): it includes six rats, they were administered 5ml/kg olive oil orally for 14 consecutive days. G (3): it includes six rats, they were administrated 90mg/kg body weight/twice daily of cefotaxime intramuscular for 14 consecutive days. G (4): it includes six rats, they were administered 5ml/kg olive oil orally concurrently with 90mg/kg body weight/twice daily of cefotaxime. Results revealed that cefotaxime induced significant increases in liver and kidney function parameters including AST, ALT, ALP. creatinine, and urea as well as decrease in albumin and total protein level. Moreover, marked an increase in malondialdehyde (MDA) and decreases in glutathione (GSH) and catalase (CAT) levels. that indicate oxidative stress levels expression in the hepatic and renal tissues following cefotaxime administration. On the beneficial side oral administration of olive oil at the dose 5ml/kg for 14 days significantly mitigate theses toxic effects. So it is concluded that olive oil has great hepatorenal antioxidant effect.

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Extra virgin olive oil enhances the hepatic antioxidant defense and inhibits cytogenotoxic effects evoked by 5-hydroxymethylfurfural in mice

Cited by 8 publications

References 46 publications

5-Hydroxymethylfurfural Exerts Negative Effects on Gastric Mucosal Epithelial Cells by Inducing Oxidative Stress, Apoptosis, and Tight Junction Disruption

5-Hydroxymethylfurfural Exerts Negative Effects on Gastric Mucosal Epithelial Cells by Inducing Oxidative Stress, Apoptosis, and Tight Junction Disruption

The Enhanced Beneficial Effect of Extra Virgin Olive Oil Over Evening Primrose Oil on Oxidative Stress, and Liver Function in Male Arthritic Rats

Amelorative effect of olive oil against hepatorenal toxicity of cefotaxime in albino rats

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