Amelorative effect of olive oil against hepatorenal toxicity of cefotaxime in albino rats

Abstract

Due to great hazard effects of antibiotic the following study aimed to investigate the adverse effect of cefotaxime in biochemical, oxidative status and histological examination of Liver and kidney tissue as well as the protective effect of olive oil. Twenty four male Wister albino rats were randomly divided into main four groups including: - G (1): Served as control group and it includes six rats, they were administrated 0.5ml of saline orally for 14 consecutive days. G (2): it includes six rats, they were administered 5ml/kg olive oil orally for 14 consecutive days. G (3): it includes six rats, they were administrated 90mg/kg body weight/twice daily of cefotaxime intramuscular for 14 consecutive days. G (4): it includes six rats, they were administered 5ml/kg olive oil orally concurrently with 90mg/kg body weight/twice daily of cefotaxime. Results revealed that cefotaxime induced significant increases in liver and kidney function parameters including AST, ALT, ALP. creatinine, and urea as well as decrease in albumin and total protein level. Moreover, marked an increase in malondialdehyde (MDA) and decreases in glutathione (GSH) and catalase (CAT) levels. that indicate oxidative stress levels expression in the hepatic and renal tissues following cefotaxime administration. On the beneficial side oral administration of olive oil at the dose 5ml/kg for 14 days significantly mitigate theses toxic effects. So it is concluded that olive oil has great hepatorenal antioxidant effect.

The Role of Vitamin C in Amelioration of Hepatorenal Toxicity of Cefotaxime in Adult Albino Rats (Histological Study)

“…This means Vitamin C act as antioxidant agent against the oxidative stress and free radical produced by cefotaxime as done by Elkomy and his team who proved that olive oil as antioxidant can decreases biomarker oxidative stress (catalase and glutathione) in the tissues of liver and kidney of cefotaxime-intoxicated rats [7].…”

“…Antibiotic with a broad spectrum activity as cefotaxime is active against aerobic and anaerobic bacteria and it's most active against Gram-negative bacteria [7]. Hence, it is used in the treatment of many infections such as typhoid fever, endocarditis, pneumonia, gonorrhea meningitis, and brain abscess but many side effects due to the cefotaxime may occur such as anaphylaxis, eosinophilia in addition to the toxic effects on the liver, kidney, stomach, and lung [8].…”