Extra ocular sebaceous carcinoma: A rare case report

Abstract

Extra ocular Sebaceous Carcinoma is a rare malignancy when compared to Peri ocular variant and these are derived from sebaceous gland epithelium. The aggressive types of extra ocular sebaceous neoplasm are reported with lymph node and visceral metastasis associated with poor prognosis. Here we report a case of extensive cutaneous extra ocular sebaceous cell carcinoma confined to large area of scalp proven by Immunohistochemistry without intra cranial involvement, distant metastases or evidence of Muir-Torre syndrome.

Rare Tumour - Sebaceous Carcinoma of the Scalp

“…This malignancy can occur as peri-ocular and extra ocular types and the former variant contributes to 75% of sebaceous neoplasms (7). Extra orbital SC has a different behaviour compared to the orbital SC which is considered less aggressive than orbital SC(3).…”

“…SC histologically may be classified as well, moderately or poorly differentiated. The morphological hall mark of sebaceous differentiation is the detection of sebaceous cells and demonstration of fat in vacuolated tumorcells (7). Poorly differentiated sebaceous carcinomas lack lipid vesicles and consist of predominantly basaloidtumor cells that imitate carcinomas such as basal cell carcinoma and squamous cell carcinoma (5).…”

“…Mortality rates irrespective of ocular or extra ocular type ranges from 9% to 50%. [7).The primary treatment of sebaceous carcinoma is a wide excision with a safety margin of 5mm to 10mm. Radiotherapy or chemotherapy has been the treatment of choice with postoperative care particularly when metastasis is confirmed.…”

A Rare Case of Sebaceous Carcinoma of Scalp With Parotid and Neck Secondaries

“…Sebaceous carcinoma is a rare aggressive skin appendageal tumor mostly arising from periorbital region. (1,2,3,4) Extra orbital sebaceous carcinoma is extremely rare. (5) We report a case of 68yr old man presented as sebaceous carcinoma scalp with parotid and neck secondaries.…”

Sebaceous carcinoma of right upper eyelid: case report and literature review

“…Sebaceous carcinoma can either be ocular or extraocular, and extraocular type is rare. 1 Advanced age, Asian or South Asian race, women, previous irradiation to the head and neck, a genetic predisposition for Muir-Torre syndrome or possibly familial retinoblastoma are various predisposing factors for sebaceous carcinoma. It mostly spread to regional lymph nodes.…”