Extra-criteria manifestations of antiphospholipid syndrome: Risk assessment and management

Abstract

Our results suggest that patients with higher aGAPSS, might be at higher risk for developing extra-criteria manifestations of APS and should therefore undergo a thorough laboratory and instrumental evaluation.

The adjusted global antiphospholipid syndrome score (aGAPSS) and the risk of recurrent thrombosis: Results from the APS ACTION cohort

“…Based on analysis of our international large-scale Registry of aPL-positive patients, the aGAPSS might help risk stratifying patients based on the likelihood of developing recurrent thrombosis in APS. 5 Significance and Innovations 1-The aGAPSS is a risk score for predicting clinical manifestations of APS. The APS ACTION is an international research network with a web-based Registry of aPL-positive patients. 3-In the APS ACTION cohort, high aGAPSS was found in patients with recurrent thrombosis.…”

“…Recently, the global APS score (GAPSS),a risk score for clinical manifestations of APS, which incorporates independent cardiovascular disease risk factors and aPL profile, was developed. The Global APS Score, initially developed and validated in systemic lupus erythematosus (SLE), has been applied in a cohort of SLE patients followed prospectively, and then validated in APS patients without associated SLE [2][3][4][5][6]. Due to the relative low prevalence of APS in the general population, estimated as an incidence of five cases per 100,000 persons per year [7,8], APS clinical research requires international efforts and multicenter collaborations.…”

Translational validation of the Global Antiphospholipid Syndrome Score in patients with thrombotic APS

“…Moreover, the highest values of GAPSS were associated with the most severe clinical manifestations of the disease (arterial thrombosis andrecurrent thrombotic events and/or pregnancy morbidity) [4]. Similarly, patients with higher aGAPSSvalues had more extra-criteria manifestations of APS [5]. In addition, they demonstrated the direct effect of IgG-aPL antibodies in the production of these molecules in monocytes isolated from healthy donors and human umbilical vein endothelial cells [6].…”

Global antiphospholipid syndrome score e anti-Beta-2-glicoproteína I domínio I na estratificação de risco trombótico da síndrome antifosfolípide: um estudo prospectivo de 4 anos

“…Um limiar de GAPSS ≥ 11 foi associado a um risco de recorrência mais alto, com razão de chances (OR, do inglês odds ratio) de 18,27 e intervalo de confiança (IC) de 3,74-114,5 37 . Não há dados de GAPSS em uma coorte brasileira exceto com o seu uso em um formato adaptado, sem a realização do aPS/PT, chamado GAPSS ajustado (aGAPSS, do inglês adjusted Global Antiphospholipid Syndrome Score) 37,40 . Quadro 2.…”

“…As tromboses mais frequentes nessa população foram a trombose venosa profunda (TVP) (57%), acidente vascular cerebral (AVC) (27%), tromboembolismo pulmonar (TEP) (14%) e trombose arterial periférica (11% Mais de um evento, n (%) (40,9) Mais de uma trombose venosa, n (%) 4 (9,1)…”