External use of radon and sulfide mineral waters in the treat-ment of experimental arthrosis

Abstract

The article presents the results of studies of the effect of radon and sulfide min-eral waters (MW) on Wistar rats with experimental arthrosis. materials and methods. Rats were randomized into 4 groups. Group 1 consisted of intact rats (control group). In the remaining three groups, a model of knee arthrosis was reproduced using dexamethasone injections. Group 2 consisted of rats with untreated pathology. Group 3 consisted of rats using radon MW procedures, and group 4 consisted of rats using sulfide MW. Results. Morphological studies have determined that using radon and sulfide MW has a curative effect on the structural and functional organization of the joint and cartilage - the manifes-tations of inflammation in the knee joints are significantly reduced, dystrophic manifesta-tions disappear, and reparative processes in cartilage improve. There are signs of an im-provement in the state of metabolic processes in the body of rats: the balance in the lipid peroxidation and antioxidant systems is restored, and the indicators of the processes of energy supply of transmembrane transport (according to the activity of magnesium-dependent Na+/K+-ATP-ase and Ca2+-ATP-ase) and protein exchange.Conclusion. Based on the data obtained, it was concluded that both applied MWs have a unidirectional, but somewhat different in strength, curative effect on the course of experimental arthrosis, which is due to different mechanisms of the biological action of radon and hydrogen sul-fide. Keywords: experimental arthrosis; morphological and metabolic indicators; radon; hydrogen sulfide; mineral water.

Experimental substantiation of the use of highly mineralized bromine chloride sodium water to correct the functional-metabolic continuum in rats with a model of distress

“…To correct the consequences of distress, it is necessary to use modulators to restore the balance of homeostasis reactions and not cause side reactions. Mineral waters (MW) of different chemical compositions are considered to be such natural nonspecific modulators [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24].…”