External quantification of myocardial perfusion by exponential infusion of positron-emitting radionuclides.

Abstract

A B S T R A C T A technique was developed and evaluated using the exponential infusion of positron-emitting diffusible tracers Actual and estimated flow correlated significantly for both the 14 KH-RBC hearts infused with H2'50 (r = 0.90, n = 89 determinations) and the 3 KH-RBC hearts infused with ["Cibutanol (r = 0.93, n = 13 determinations). In addition, the required exponentially increasing arterial tracer concentrations were shown to be attainable in vivo in dogs and rhesus monkeys after intravenous exponential administrations of tracer. The results suggest that the approach developed employing exponential tracer infusion permits accurate measurement of myocardial perfusion and that it should prove useful in the noninvasive measurement of regional myocardial perfusion in vivo by positron emission tomography.

Radiosynthesis, Preclinical, and Clinical Positron Emission Tomography Studies of Carbon-11 Labeled Endogenous and Natural Exogenous Compounds

“…Preclinical Studies. [1][2][3][4][5][6][7][8][9][10][11] C]Butanol has been evaluated in rats, 24−28 dogs, 25,29,30 and monkeys. 16,31 In Sprague-Dawley rats, a measurement of CBF was performed after a bolus intravenous injection of [1][2][3][4][5][6][7][8][9][10][11] C]butanol.…”

“…[ 1 - 11 C]Butanol has been evaluated in rats, − dogs, ,, and monkeys. , In Sprague-Dawley rats, a measurement of CBF was performed after a bolus intravenous injection of [ 1 - 11 C]butanol. To improve the preconditions for external hyperthermia treatment of cancer, Knapp et al .…”

“…1 ]­nonane, followed by oxidation in an alkaline medium, produced [ 1 - 11 C]­butanol within 65 min with a RCY of 33–71% based on the delivered activity of [ 11 C]­CO, and radiochemical purity (RCP) >95% . The reaction of [ 11 C]­CO 2 with 1 -propylmagnesium bromide, followed by lithium aluminum hydride (LAH) reduction, produced [ 1 - 11 C]­butanol within 27 min with a RCY of 55–74% and RCP of 95–99%. , A robotic synthesis of [ 1 - 11 C]­butanol taking 25 min has also been described with a RCY of 11–15% …”

“…Carbon-11 alcohols have been mainly used to study their distribution in the body and measure the blood-brain barrier (BBB) permeability and cerebral blood flow (CBF) (Table 1). 1-rats, 18,19 rabbits, 18 dogs, 18,20 1-rats, 24−28 dogs, 25,29,30 monkeys, 16,31 1). This approach is regularly used in the "wet method" of [ 11 C]CH 3 I production, where [ 11 C]methanol is subsequently iodinated.…”

“…34 The reaction of [ 11 C]CO 2 with 1-propylmagnesium bromide, followed by lithium aluminum hydride (LAH) reduction, produced [1- 11 C]butanol within 27 min with a RCY of 55− 74% and RCP of 95−99%. 29,34 A robotic synthesis of [1- 11 C]butanol taking 25 min has also been described with a RCY of 11−15%. 43 Waterhouse et al described the automated radiosynthesis of [1- 11 C]butanol consistent with Good Manufacturing Practice (GMP) guidelines.…”