External irradiation for malignant thyroid tumors.

Chung, C T; Sagerman, Robert H.; Ryoo, Monica C.; King, G A; Yu, Wen-cai; Dalal, P S; Emmanuel, Innocent

doi:10.1148/radiology.136.3.6773105

Cited by 32 publications

(11 citation statements)

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“…During this limited follow-up study, the 5-and 10-year survival rates were comparable with those in previous studies [24]. The role of adjuvant external radiotherapy for the post-operative treatment of well differentiated human thyroid cancer is still a controversial issue [25,26], although its use has been reported in patients with well-differentiated thyroid cancer with post-operative residual disease, local recurrence, or in 1311 treatment refractory patients [27,28]. In a recent study with a limited followup, Lin et al [29] found that external radiotherapy did not improve the survival of patients with welldifferentiated thyroid cancer at an advanced clinical stage.…”

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confidence: 76%

Prognostic Variables of Papillary Thyroid Carcinomas with Local Invasion.

et al. 1999

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supporting

confidence: 76%

Prognostic Variables of Papillary Thyroid Carcinomas with Local Invasion.

et al. 1999

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“…3 Occasional reports have described good results in undifferentiated thyroid carcinoma with radiation therapy alone or in combination with chemotherapy. 6,7 However, in these reports the small-cell type anaplastic lesions, which usually respond well to radiation and chemotherapy and carry a much better prognosis, were not classified and analyzed separately, therefore creating a misleading favorable bias. Furthermore, on routine light microscopic examination, many pathologists find the spindle and giant cell variants indistinguishable from large cell lymphomas, which are also more responsive to radiation and chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

Spindle and Giant Cell Carcinoma of the Thyroid

et al. 1983

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A retrospective chart review of all 15 patients presenting with anaplastic spindle and giant cell carcinoma of the thyroid at King Faisal Specialist Hospital between July 1975 and June 1982 was undertaken to evaluate the clinical presentation and treatment results. The mean age was 58.7 years and 11 patients were females. Fourteen patients had nodal metastases and 12 had hematogenous spread on presentation. There were two subpopulations in this group: in eight, the average duration of the lesion was 4.5 months, and in seven, the average duration was 8.6 years. This finding suggests that the risk of transformation from differentiated to anaplastic thyroid malignancy is not time related. Ten patients were treated with surgery and/or radiotherapy. In two cases chemotherapy was added. The mean survival for all patients was 2.5 months. Treatment was largely ineffective and therefore should be reserved for the small group of patients who present with minimal disease. R Cowgill, MA Ali, JO Sieck, S El-Akkad, Spindle and Giant Cell Carcinoma of the Thyroid. 1983; 3(3): 159-162

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“…All reported series are retrospective by nature. Recent data indicate that external radiotherapy can be used for curative treatment in patients with microscopic residual or gross disease after surgery [17,18]. Tubiana et al [8] reported similar survival rates for patients who received postoperative irradiation and for those who received surgery alone.…”

Section: Medullary Thyroid Cancermentioning

confidence: 99%

External Radiotherapy of Thyroid Cancer

Pöllinger

Dühmke

2001

Oncol Res Treat

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Differentiated thyroid cancer comprises papillary, mixed papillary-follicular and follicular adenocarcinomas. They are mostly hormone-sensitive and respond to thyroid-stimulating hormone (TSH) suppression. The standard treatment is total thyroidectomy, ¹³¹I therapy and thyroid hormone suppression therapy. Adjuvant external radiotherapy is discussed controversially. Most authors recommend adjuvant external radiotherapy for extra-capsular tumor extension. Decision on an individual basis should be made for patients with lymph node involvement. In the case of incomplete surgical resection, external radiotherapy should be applied if second surgery is not possible. For medullary thyroid cancer, external beam radiotherapy seems to be beneficial for patients with surgically inaccessible disease, with microscopic residual or gross tumor after surgery, with recurrent locoregional disease, or with surgically unmanageable metastases. Patients suffering from anaplastic thyroid cancer should receive combined treatment consisting of extensive surgery, external irradiation with total doses up to 60 Gy, and chemotherapy. The combined treatment modality leads to higher local control rates and prolongs survival.

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External irradiation for malignant thyroid tumors.

Cited by 32 publications

References 0 publications

Prognostic Variables of Papillary Thyroid Carcinomas with Local Invasion.

Prognostic Variables of Papillary Thyroid Carcinomas with Local Invasion.

Spindle and Giant Cell Carcinoma of the Thyroid

External Radiotherapy of Thyroid Cancer

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