External Beam Radiation Therapy for Resectable Soft Tissue Sarcoma: A Systematic Review and Meta-Analysis

Abstract

This meta-analysis supports the use of EBRT for local tumor control in patients with resectable STSs. Based on a small number of non-randomized studies, a positive effect on OS may exist in the subgroup of retroperitoneal STSs.

Hyperthermic isolated limb perfusion, preoperative radiotherapy, and surgery (PRS) a new limb saving treatment strategy for locally advanced sarcomas

“…Postoperative EBRT following HILP and delayed surgical resection was shown to improve the local tumor control in locally advanced ESTS, whereas the timing of EBRT does not seem to influence the oncological outcome in resectable ESTS. [33][34][35][36] The distant failure rate in the current series (45%) seems similar to the 40% previously reported. 29 However, due to the small sample size and relative short follow-up, the current results should be interpreted with some caution and they need further confirmation in larger patientcohorts.…”

“…However, the difference in local recurrence rate might also be caused by the consequent use of preoperative EBRT in the current series. Postoperative EBRT following HILP and delayed surgical resection was shown to improve the local tumor control in locally advanced ESTS, whereas the timing of EBRT does not seem to influence the oncological outcome in resectable ESTS . The distant failure rate in the current series (45%) seems similar to the 40% previously reported .…”

Clinical Features and Treatment Outcomes of Vulvar Sarcoma: A Single-Institution Review of 21 Cases

“…The role of chemoradiation as adjuvant treatment for VS is also unclear. Postoperative radiotherapy had been found to be bene cial for a variety of sarcomas [25]. Evidence from sarcoma of extremities suggested an improvement of recurrence-free survival in patients receiving postoperative chemotherapy [26].…”

Malignant peripheral nerve sheath tumor of nasal cavity and paranasal sinus with 13 years of follow‐up—A case report and review of literature

“…The advantage of a postoperative radiation paradigm includes a lower rate of postoperative complications and the possibility that radiation can be avoided if the final margins are widely negative. Radiation treatment confers an improvement in local control, but not overall survival . However, excellent survival rates have been reported after definitive or postoperative radiation treatment for sarcoma of the head and neck region …”