Malignant peripheral nerve sheath tumor of nasal cavity and paranasal sinus with 13 years of follow‐up—A case report and review of literature

Thomas, Toms Vengaloor; Abraham, Anu; Bhanat, Eldrin; Hmada, Youssef Al; Albert, Alexandra; Vijayakumar, Srinivasan; Stinger, Scott P.; Packianathan, Satyaseelan

doi:10.1002/ccr3.2465

Cited by 9 publications

(7 citation statements)

References 36 publications

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“…The extracellular matrix in less cellular areas is usually myxoid, which can be abundant in up to 10% of cases. Clusters of small rounded blood vessels are commonly seen in high-grade tumors [ 1 ].…”

Section: Discussionmentioning

confidence: 99%

“…Malignant peripheral nerve sheath tumors (MPNSTs) are very rare sarcomas of the nasal cavity and paranasal sinuses. [ 1 ] It is defined as any malignant neoplasm arising from or differentiating toward the cells of the peripheral nerve sheath, apart for tumors originating from the epineurium or the peripheral nerve vasculature. [ 2 ] MPNSTs account for about 5–10% of all soft-tissue sarcomas, with only about 8–16% occurring within the head and neck region [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

“…Correspondingly, a MPNST of the head and neck region is extremely rare and even rarer when located in the nasal cavity or paranasal sinuses. [ 1 ]…”

Section: Introductionmentioning

confidence: 99%

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Malignant peripheral nerve sheath tumors of the sino-nasal tract: about an unusual case report

Boujida

Elouazzani

Derqaoui

et al. 2022

Journal of Surgical Case Reports

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Malignant peripheral nerve sheath tumors are defined as malignant tumors arising from or differentiating toward the cells of the peripheral nerve sheath. They occur in about 8–16% within the head and neck region. Morphologically, some malignant tumors look like malignant peripheral nerve sheath tumors, particularly in the head and neck location; however, immunohistochemistry have a great contribution to distinguish between them. This case report is on a 45-year-old woman with a malignant peripheral nerve sheath tumor located in the sino-nasal tract.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Malignant peripheral nerve sheath tumors of the sino-nasal tract: about an unusual case report

Boujida

Elouazzani

Derqaoui

et al. 2022

Journal of Surgical Case Reports

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“…Malignant neurilemmoma in the nasal cavity and paranasal sinuses is extremely rare. 6,7 The ethmoid and maxillary…”

Section: Discussionmentioning

confidence: 99%

“…Ear, Nose & Throat Journal 102 (7) sinuses most often occur, and the nasal fossa and sphenoid sinus come next. 8 Most cases of neurilemmomas occur between the second and fifth decade of life and have no gender or race predilection.…”

Section: Np366mentioning

confidence: 99%

Neurilemmoma of the Nasal Cavity and Paranasal Sinuses

Wang

2021

Ear Nose Throat J

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Objectives: Neurilemmoma in the nasal cavity and paranasal sinuses is very rare. The study aimed to improve the understanding of neurilemmoma in the nasal cavity and paranasal sinuses. Materials and Methods: The clinical data of 10 patients with neurilemmoma in the nasal cavity and paranasal sinuses treated from January 2014 to June 2019 in our hospital were retrospectively studied. Results: There were 6 females and 4 males patients in our study. The mean age was 49.5 years (range 37-77 years), and the most common clinical symptom was unilateral nasal obstruction. The site of tumor included the nasal cavity, maxillary sinus, ethmoid sinus, and sphenoid sinus. There were 2 cases with malignant neurilemmoma. Nine patients underwent functional endoscopic sinus surgery (FESS); however, 1 patient underwent FESS combined with the lateral rhinotomy for complete resection of the tumor. Two patients with malignant neurilemmoma received postoperative radiotherapy. The mean follow-up was 3.82 years (range 2-7 years). There were no incidences of tumor recurrence during the study period. Conclusions: Neurilemmoma in the nasal cavity and paranasal sinuses is a mainly benign tumor. Complete surgical excision by FESS is the only treatment option for neurilemmoma in the nasal cavity and paranasal sinuses; while malignant neurilemmoma needs postoperative radiotherapy.

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International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors

Kuan

Wang

Adappa

et al. 2024

Int Forum Allergy Rhinol

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BackgroundSinonasal neoplasms, whether benign and malignant, pose a significant challenge to clinicians and represents a model area for multidisciplinary collaboration in order to optimize patient care. The International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors (ICSNT) aims to summarize the best available evidence and presents 48 thematic and histopathology‐based topics spanning the field.MethodsIn accordance with prior ICAR documents, ICSNT assigned each topic as an Evidence‐Based Review with Recommendations, Evidence‐Based Review, and Literature Review based on level of evidence. An international group of multidisciplinary author teams were assembled for the topic reviews using the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses format, and completed sections underwent a thorough and iterative consensus‐building process. The final document underwent rigorous synthesis and review prior to publication.ResultsThe ICNST document consists of 4 major sections: general principles, benign neoplasms and lesions, malignant neoplasms, and quality of life and surveillance. It covers 48 conceptual and/or histopathology‐based topics relevant to sinonasal neoplasms and masses. Topics with a high level of evidence provided specific recommendations, while other areas summarized the current state of evidence. A final section highlights research opportunities and future directions, contributing to advancing knowledge and community intervention.ConclusionAs an embodiment of the multidisciplinary and collaborative model of care in sinonasal neoplasms and masses, ICSNT was designed as a comprehensive, international, and multidisciplinary collaborative endeavor. Its primary objective is to summarize the existing evidence in the field of sinonasal neoplasms and masses.This article is protected by copyright. All rights reserved

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Malignant peripheral nerve sheath tumor of nasal cavity and paranasal sinus with 13 years of follow‐up—A case report and review of literature

Cited by 9 publications

References 36 publications

Malignant peripheral nerve sheath tumors of the sino-nasal tract: about an unusual case report

Malignant peripheral nerve sheath tumors of the sino-nasal tract: about an unusual case report

Neurilemmoma of the Nasal Cavity and Paranasal Sinuses

International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors

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