Extent of surgery in the management of phyllodes tumor of the breast: A retrospective multicenter study from India

Verma, Sushil Kumar; Singh, R. P.; Rai, Arvind; Pandey, CP; Singh, Mahendra; Mohan, Nitesh

doi:10.4103/0973-1482.77085

Cited by 11 publications

(7 citation statements)

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“…The phyllodes tumor patients enrolled in this study were younger than expected. In previous studies, it has been reported that patients with borderline/malignant phyllodes tumors were older than those with benign phyllodes tumors (3,4). In this study, it was detected that the borderline/malignant phyllodes tumor patients also had more advanced age.…”

Section: Discussionsupporting

confidence: 61%

“…The assumption that phyllodes tumors may be affected by hormonal milieu suggest a relationship between these types of tumors and menopausal status. However, in both previous reports and the current study a significant association was not detected between the histopathological subtype of phyllodes tumor and menopausal status (3). Phyllodes tumors, similar to breast cancer, are often seen in women.…”

Section: Discussioncontrasting

confidence: 50%

“…The rate of axillary lymph node metastasis was reported as 0-2% (3,13). In this study, sentinel lymph node biopsy was performed in the patient who underwent mastectomy, and metastasis was not detected.…”

Section: Discussionmentioning

confidence: 99%

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Analysis of patients with phylloides tumor of the breast

Atalay

Kınaş

Çelebioğlu

2014

UCD

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Section: Discussionsupporting

confidence: 61%

Section: Discussioncontrasting

confidence: 50%

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Analysis of patients with phylloides tumor of the breast

Atalay

Kınaş

Çelebioğlu

2014

UCD

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“…PTs spread hematogenously. The rate of axillary metastasis is low (0%-2%) and therefore routine axillary examination is not recommended (8,22). However, axillary examination can be performed in aggressive tumors with a diameter greater than 5 cm and high mitotic activity.…”

Section: Discussionmentioning

confidence: 99%

Phyllodes Tumors of the Breast: A Single-Center Experience

Yılmaz

Karakaya

Özgen

et al. 2021

EJBH

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Phyllodes tumors (PTs) of the breast are rare fibroepithelial tumors that constitute 0.3%-0.5% and 2%-3% of primary breast tumors and fibroepithelial tumors, respectively (1). They may be observed in all ages; nevertheless, they are mostly observed in the age range of 35-55 years (2). They are radiologically and clinically similar to fibroadenomas (FAs); however, they are differentiated from FAs with increased cellularity and metastatic invasion capacity of the local recurrence and malignant types. Although it was previously termed "cystosarcoma phyllodes" by Müller because of its macroscopically similar appearance with sarcoma, it is now termed PT by World Helath Organization (3, 4). PTs are classified as benign, borderline, and malignant phyllodes based on histological features such as cellular atypia, mitotic count, tumor necrosis, stromal overgrowth, and tumor margins. Approximately 60%-75% of all PT cases are benign (5).The essential treatment modality is by surgical intervention. Although the National Comprehensive Cancer Network (NCCN) guidelines recommend large local excision with a least surgical margin of 1 cm, recent studies have reported the application of excisions with narrower surgical margins. Tumor size, surgical therapeutic technique, and tumor-related histopathological features have been found to be associated with recurrences, as well as surgical margin status in literature (6). In the present study, we aimed to analyze the clinicopathological findings, our treatment approach, and treatment outcomes in patients diagnosed with PT, who applied to our clinic. Materials and MethodsThe hospital records of 26 patients, who were treated for PT of the breast between January 2008 and December 2019 in the Clinic of General Surgery Department of Pamukkale University Medical Faculty, were retrospectively analyzed, following approval of the study by The Clinical

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“…Mastectomy should be reserved for special indications such as local recurrence, gross tumors (>10 cm), inappropriate tumor-breast ratio, and cases in which tumor-free surgical margins are impossible to be achieved. The excisions must be carried out with the effort to obtain at least a 1 -2 cm tumor-free distance from the surgical margins (10,(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23). In their study, Mangi et al20 reported that this distance was less than 1 cm in all cases of local recurrences, and De Roos et al (22) stated that all local recurrences were the outcomes of insufficient primary surgery having left positive surgical margins in the initial operations.…”

Section: Surgical Treatmentmentioning

confidence: 99%