Phyllodes Tumors of the Breast: A Single-Center Experience

Yılmaz, Sevda; Karakaya, Yeliz Arman; Özgen, Utku; Erdem, Ergün

doi:10.4274/ejbh.2020.5961

Cited by 5 publications

(13 citation statements)

References 28 publications

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“…Cytological atypia was not observed, and the mean mitotic figure number per 10 HPF was 1.8 (1-3). On the histological examination of borderline PT, increased stromal cellularity was noted (Figure -4), and the mean mitotic figure number per 10 HPF was 6.6 (5)(6)(7)(8). Nuclear pleomorphism, prominent nucleoli, cytological atypia, bleeding, and necrosis were observed in malignant PT.…”

Section: Resultsmentioning

confidence: 99%

“…There is no pathognomonic radiological finding that differentiates between FAs and benign, borderline, and malignant phyllodes tumors. Recent studies have reported that contrast-enhanced MRI findings such as a tumor size over 3 cm, poorly circumscribed and microlobular structure, heterogeneous appearance in echogenicity, hypervascularity, and the presence of internal cystic cavities support PT in the differential diagnosis of two tumors 6,10,12,13 . Moreover, solid components with greater concentration in hemorhagic cystic spaces on MRI suggest PT.…”

Section: Discussionmentioning

confidence: 99%

“…PT shows hematogenous spread. The rate of axillary metastasis is low, and therefore it has been observed that axillary lymph node sampling is not required in PT cases 6,12 . The National Comprehensive Cancer Network(NCCN) recommends the use of RT in recurrent malignant PT cases.…”

Section: Discussionmentioning

confidence: 99%

“…The National Comprehensive Cancer Network(NCCN) recommends the use of RT in recurrent malignant PT cases. Some authors recommend adjuvant RT to reduce the likelihood of local recurrence in both borderline and malignant PT patients treated surgically 3,6,8,12 . Although there is no routine chemotherapy protocol for the treatment of PT, it is recommended that it be treated like sarcoma.…”

Section: Discussionmentioning

confidence: 99%

“…Patients with a positive surgical margin and malignant histology should undergo further surgery to achieve clear surgical margins. Adjuvant treatment options include radiation therapy, which has been shown to reduce local recurrence 5,6 . However, the role of adjuvant radiotherapy and chemotherapy in malignant PT remains unclear.…”

Section: Introductionmentioning

confidence: 99%

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Phyllodes Tumor of The Breast: Histopathological and Clinical Results of 13 Cases

Küçükosmanoğlu¹,

Karanis²,

Köksal³

2021

jamp

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Phyllodes tumors (PT) are biphasic tumors originating from cleft-like spaces lined by epithelial cells and the hypercellular stroma. PT is a very rare tumor of the breast. The World Health Organization (WHO) classifies it as benign, borderline, or malignant. In this research, we aimed to describe the radiological, pathological, and clinical results of patients, who were admitted to our hospital and diagnosed with PT and evaluate them in the light of the literature. A total of 13 PT patients diagnosed in the pathology laboratory of Konya Training and Research Hospital between January 2010 and December 2019 were retrospectively analyzed. The mean age of the patients was 42.69 years (range, 18-64). The tumor location was the right breast in 4 (30.7%) patients and the left breast in 9 (69.3%) patients. Of the malignant PT, 1 (20%) was located in the right breast and 4 (80%) were located in the left breast. Of the patients, 5 (38.5%) were diagnosed with benign PT, 3 (23%) with borderline PT, and 5 (38.5%) were diagnosed with malignant PT. The mean tumor size was 7.7 cm, and the diameter of each of the malignant PT was larger than 7.7 cm, with a mean diameter of 12.9 cm. PT should be correctly identified at initial diagnosis and treated effectively, as the risk of recurrence is high. To develop new treatment modalities, we should especially understand malignant lesions well, and also attach importance to patient education and awareness.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Phyllodes Tumor of The Breast: Histopathological and Clinical Results of 13 Cases

Küçükosmanoğlu¹,

Karanis²,

Köksal³

2021

jamp

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The Defect Repair After a Giant Malignant Phyllodes Tumor Resection of Breast Using a Kiss Flap

Luo

Zou

et al. 2022

Indian J Surg

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Malignant phyllodes tumors of the breast are fairly rare and fast-growing tumors. They are not sensitive to chemotherapy or hormonal therapy. Therefore, the primary treatment for malignant phyllodes tumors is wide surgical excision. Herein, we report a case study which featured a 26-year-old woman presented with a giant malignant phyllodes tumor measuring 20 × 17 × 13 cm. In order to reduce the chance of local recurrence, treatment for these types of tumors usually involves extensive excision with at least 1 cm of surgical margins. The patient underwent mastectomy with negative surgical margins, which left a large skin defect of 25 × 15 cm. Repair of such a large skin defect is a challenge to breast surgeons. This is the first reported case in which a “kiss” flap was successfully used to repair the skin defect created after resection of a giant malignant phyllodes tumor. The kiss flap could be considered as an effective and simple method to repair large chest wall defects after resection of giant phyllodes tumors.

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Phyllodes tumors: A retrospective study of 22 cases in the department of gyneco obstetrics 2 of the Hassan II university hospital

Yassine¹,

Conte²,

Aloui³

et al. 2023

OGIJ

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Introduction: Phyllodes tumors (PTs) of the breast are rare fibro-epithelial tumors, which represent 1% of all primary breast tumors with an incidence of 0.3% to 0.9%, and they represent 2% to 3% of fibroepithelial neoplasms. Their diagnosis is based on histology. Our work aims to determine the epidemiological, clinical, histological and therapeutic aspects of PTs. Materials and methods: This is a retrospective study conducted in the gyneco-obstetric II department at the hospital center Hassan II, between January 1st 2015, and December 31st 2020 of, on 22 patients histologically proved cases of phyllodes tumors. Results: The study was conducted on 22 women, for whom the average diagnosis age was 35.6years old from 19 to 63years. 63.6% of the patients were nulliparous. The main clinical manifestation was a unilateral breast nodule measuring between 1 and 15.5cm (5cm on average). Mammographic exploration in the majority of cases revealed hyperdense opacity, roughly oval, well limited, often with regular outlines. The histological type was benign in 68.18% of cases, borderline in 18.18% and phyllodes sarcoma in 13.63%. The treatment was conservative in 86.37% of cases (lumpectomy), and radical in 13.63% of cases (mastectomy). After surgical treatment, 2 patients had insufficient resection limits and subsequently benefited from tumor bed revision. After follow-up, two tumors locally recurred with a huge mass that took up the entire breast. The two patients who had undergone a mastectomy and whose development was marked by the appearance of a second recurrence on the mastectomy scar, one of which was operable and the second had pulmonary metastases hence the indication of chemotherapy. Conclusion: Out of this study, we noticed that Phyllodes tumors of the breast mainly affect young women. The diagnostic confirmation necessarily requires histological proof which is not often easy by only biopsy. The best management of this tumor remains adequate surgical resection with healthy margins, while emphasizing the need for monitoring because the risk of recurrence is always present. The prognosis is based on the histological characteristics of the tumor and the quality of tumor excision.

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Phyllodes Tumors of the Breast: A Single-Center Experience

Cited by 5 publications

References 28 publications

Phyllodes Tumor of The Breast: Histopathological and Clinical Results of 13 Cases

Phyllodes Tumor of The Breast: Histopathological and Clinical Results of 13 Cases

The Defect Repair After a Giant Malignant Phyllodes Tumor Resection of Breast Using a Kiss Flap

Phyllodes tumors: A retrospective study of 22 cases in the department of gyneco obstetrics 2 of the Hassan II university hospital

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