Extent of Emphysema on HRCT Affects Loss of Fat-free Mass and Fat Mass in COPD

Kurosaki, Hiroko; Ishii, Takeo; Motohashi, Norihisa; Motegi, Takashi; Yamada, Kazutoyo; Kudoh, Shoji; Jones, Rupert; Kida, Kenji

doi:10.2169/internalmedicine.48.1102

Cited by 38 publications

(32 citation statements)

References 40 publications

(23 reference statements)

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“…Most of the studies have focused on TNF-a [7][8][9][10][12][13][14], and/or the TNF-a receptors [8,9,14,17,[28][29][30], whereas two examined CRP [15,31]. The earliest published studies found elevated levels of TNF-a [7][8][9][10] in cahectic patients, whereas in later studies [12,13], no such difference was found.…”

Section: Discussionmentioning

confidence: 99%

“…Among these studies there was no statistically significant relationship between levels of TNF-a and body composition in the three studies which measured TNF-a [12][13][14]. In the fourth study, CRP was negatively associated with FFMI in bivariate analyses, but not after adjustment for confounder age, number of lymphocytes, handgrip strength, walking distance on 6-min walk test and per cent lowattenuating area on high-resolution computed tomography scans [15]. The total number of COPD patients in these studies was generally small and varied between 20 subjects [13] and 99 subjects [12].…”

mentioning

confidence: 89%

“…Four later studies have included measurements of fat-free mass index (FFMI) by bioelectrical impedance [12][13][14][15]. Among these studies there was no statistically significant relationship between levels of TNF-a and body composition in the three studies which measured TNF-a [12][13][14].…”

mentioning

confidence: 99%

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Body composition and plasma levels of inflammatory biomarkers in COPD

Eagan¹,

Aukrust²,

Ueland³

et al. 2010

European Respiratory Journal

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Previous studies suggest a relationship between systemic inflammation and body composition in chronic obstructive pulmonary disease (COPD). We examined the relationships between body composition (fat free mass index (FFMI) kg?m -2 and fat mass index (FMI) kg?m -2 ) and three plasma inflammatory markers C-reactive Protein (CRP), soluble tumour necrosis factor receptor 1 (sTNF-R1) and osteoprotegerin (OPG) CRP and sTNF-R1 levels correlated positively with both FFMI and FMI. The adjusted regression coefficients for an increase in logCRP per unit increase in FFMI was 1.23 (1.14-1.33) kg?m -2 and 24.9 (11.8-38.1) kg?m -2 for sTNF-R1. Higher FMI was associated with a lower OPG, with adjusted regression coefficient -0.14 (-0.23--0.04), whereas FFMI was unrelated to OPG.In conclusion, COPD patients with low FFMI had lower not higher plasma levels of CRP and sTNF-R1, whereas higher fat mass was associated with higher CRP and sTNF-R1 and lower OPG.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 89%

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Body composition and plasma levels of inflammatory biomarkers in COPD

Eagan¹,

Aukrust²,

Ueland³

et al. 2010

European Respiratory Journal

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“…Disease severity and systemic corticosteroids are associated with the risk of osteoporosis (156). Because the prevalence of osteoporosis is associated with a low FFM (157), it can be speculated that loss of bone and muscle mass share common mechanisms (158)(159)(160).…”

Section: American Thoracic Society Documentsmentioning

confidence: 99%

An Official American Thoracic Society/European Respiratory Society Statement: Update on Limb Muscle Dysfunction in Chronic Obstructive Pulmonary Disease

Maltais¹,

Decramer²,

Casaburi³

et al. 2014

Am J Respir Crit Care Med

850

1,033

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“…Several studies have demonstrated an inverse relationship between the extent of emphysema and the degree of malnutrition represented by BMI and specially FFMI 24 . Although not well established for all patients, some data suggest that nutritional support in COPD patients who are malnourished, may have a positive impact on exercise capacity and quality of life of these patients 25 .…”

Section: Emphysema: Association With Malnutrition and Osteoporosismentioning

confidence: 99%

The Impact of Emphysema on Chronic Obstructive Pulmonary Diseases

Torres¹,

Casanova²

2017

BRN

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Emphysema is defined as an abnormal and permanent enlargement of the air spaces distal to the terminal bronchioles that is accompanied by destruction of the air space walls, with no obvious fibrosis (i.e. there is no fibrosis visible to the naked eye) and it is usually associated to tobacco smoking. Although it is included in the pathological definition of chronic obstructive pulmonary disease (COPD), not all COPD patients have emphysema and its impact on the clinical presentation and the natural history of the disease is variable. The present review will cover the prevalence of emphysema in COPD patients, its impact on the clinical presentation, association with comorbidities and the main outcomes of the disease: exacerbations, lung function decline and mortality. In this review, we will only evaluate the relationship of tobacco-related emphysema with COPD. (BRN Rev. 2017;3:235-46)

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Extent of Emphysema on HRCT Affects Loss of Fat-free Mass and Fat Mass in COPD

Abstract: Background Although muscle loss is thought to be a prognostic factor in chronic obstructive pulmonary disease (COPD)

Cited by 38 publications

References 40 publications

Body composition and plasma levels of inflammatory biomarkers in COPD

Body composition and plasma levels of inflammatory biomarkers in COPD

An Official American Thoracic Society/European Respiratory Society Statement: Update on Limb Muscle Dysfunction in Chronic Obstructive Pulmonary Disease

The Impact of Emphysema on Chronic Obstructive Pulmonary Diseases

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