Body composition and plasma levels of inflammatory biomarkers in COPD

Abstract

Previous studies suggest a relationship between systemic inflammation and body composition in chronic obstructive pulmonary disease (COPD). We examined the relationships between body composition (fat free mass index (FFMI) kg?m -2 and fat mass index (FMI) kg?m -2 ) and three plasma inflammatory markers C-reactive Protein (CRP), soluble tumour necrosis factor receptor 1 (sTNF-R1) and osteoprotegerin (OPG) CRP and sTNF-R1 levels correlated positively with both FFMI and FMI. The adjusted regression coefficients for an increase in logCRP per unit increase in FFMI was 1.23 (1.14-1.33) kg?m -2 and 24.9 (11.8-38.1) kg?m -2 for sTNF-R1. Higher FMI was associated with a lower OPG, with adjusted regression coefficient -0.14 (-0.23--0.04), whereas FFMI was unrelated to OPG.In conclusion, COPD patients with low FFMI had lower not higher plasma levels of CRP and sTNF-R1, whereas higher fat mass was associated with higher CRP and sTNF-R1 and lower OPG.

Systemic Inflammation in Patients with Chronic Obstructive Pulmonary Disease: Results from the Cosmic Study

“…However, one study found decreasing levels of sTNFαR1 with lower FEV 1 values in multiple regression analysis [20]. These data could not be confirmed in the present study.…”

“…In line, Takabatake and colleagues reported an association between both sTNFα receptors and the percentage of fat mass in COPD [24]. A recent manuscript concluded that both circulating CRP and sTNFαR1 were positively associated with fat mass rather than fat free mass [20], data which are confirmed in the present study.…”

“…We did not find a gender effect on the analysed markers of systemic inflammation, which was also found in other studies [20]. However, worth noting, differences in other mediators as the Adipokines seem gender related.…”

Inflammatory bowel diseases, chronic liver diseases and the lung

“…Second, both COPD and IBD are considered to be driven by low-grade chronic systemic inflammation so that circulating lymphocyte activity may be a contributory factor [45][46][47]. During inflammation, bronchial lymphoid tissue is regulated by lymphocyte traffic from the lung tissue through the general circulation [48].…”

Inflammatory biomarkers in chronic obstructive pulmonary disease

“…T.M.L.Eagan et al [46] получили обратные результаты: выявлена взаимо связь FMI и FFMI и уровня СРБ и sTNF R1. В проти воположность показателям СРБ и sTNF R1, низкий FMI ассоциировался с высоким остеопротегирином (OPG), хотя связь между FFMI и OPG не была най дена.…”