Extensively drug-resistant Acinetobacter baumannii: risk factors for acquisition and prevalent OXA-type carbapenemases—a multicentre study

Park, Yoon Soo; Lee, Hyukmin; Lee, Kkot Sil; Hwang, Seung Sik; Cho, Yong Kyun; Kim, Hyo Youl; Uh, Young; Chin, Bum Sik; Han, Sanghoon; Jeong, Seok Hoon; Lee, Kyungwon; Kim, June Myung

doi:10.1016/j.ijantimicag.2010.06.049

Cited by 35 publications

(30 citation statements)

References 34 publications

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“…Kuo et al reported that the occurrence of the bla OXA-23 -like gene was 58% in hospital C in northern Taiwan (9). A report from South Korea revealed that the occurrence of the bla OXA-23 -like gene was 77% (10). These results are similar to those in our report.…”

Section: Discussionsupporting

confidence: 90%

Types and Prevalence of Carbapenem-Resistant Acinetobacter calcoaceticus-Acinetobacter baumannii Complex in Northern Taiwan

Hsieh

Wang

Feng

et al. 2014

Antimicrob Agents Chemother

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eThe frequency of the carbapenem-resistant Acinetobacter calcoaceticus-Acinetobacter baumannii (CRACB) complex increases annually in our hospitals. However, the types and prevalence of carbapenemases among isolates still remain unclear. In this study, we identified and collected 672 carbapenem-resistant isolates from a medical center in Northern Taiwan between April and December of 2010. There were 577 genospecies 2 (Acinetobacter baumannii), 79 genospecies 13TU, and 16 genospecies 3 isolates. The isolates had an acquired bla OXA-24 -like gene, which was confirmed by sequencing for the encoded OXA-72 carbapenemase, and were often associated with high-level carbapenem resistance. These CRACB complex isolates remained susceptible to colistin (100%). The genotyping of isolates was conducted using pulsed-field gel electrophoresis with ApaI digestion. In most clonally related groups, patients were from both branch hospitals. The results indicate that interhospital dissemination of clones occurred. This study provides updated data on the types and prevalence of the CRACB complex. In addition, it presents a warning on the emergence and spread of CRACB complex harboring bla OXA-24 -like genes in northern Taiwan.

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Section: Discussionsupporting

confidence: 90%

Types and Prevalence of Carbapenem-Resistant Acinetobacter calcoaceticus-Acinetobacter baumannii Complex in Northern Taiwan

Hsieh

Wang

Feng

et al. 2014

Antimicrob Agents Chemother

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“…baumannii is usually treated with broad-spectrum antibiotics, including carbapenems. Carbapenems such as imipenem and meropenem are often the antibiotics of last resort for such infection, and resistance against them is considered an alarming situation [13,14]. Many risk factors are associated with the prevalence of A. baumannii and the development of MDR-A.…”

Section: Introductionmentioning

confidence: 99%

Patient Demographics and Characteristics of Infection with Carbapenem-Resistant <i>Acinetobacter baumannii</i> in a Teaching Hospital from the United States

Vaze¹,

Emery²,

Hamilton³

et al. 2013

AID

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A characterization of the clinical demographic features of patients with infection caused Acinetobacter baumannii, and the antibiotyping of the isolates recovered from these patients was undertaken, with a special reference to carbapenemresistant variants, and their risk factors. This study was conducted retrospectively from January 2010 to March 2011 at a 616-bed tertiary care university hospital. Sixty-four patients were identified. Clinical and microbiological data were analyzed for risk factors and demographic features to derive relative risk and odds ratio. We identified 100 A. baumannii from 64 patients during 15 months period. Significant risk factors were working age (18 -60 years), male gender, hospital stay (>1 week but <1 month), prior hospitalization, in a progressive care nursing units, respiratory/mechanical ventilation, polymicrobial infections and prior antibiotic therapy. Methicillin-resistant staphylococcus aureus (MRSA), Pseudomonas aeruginosa, and Klebsiella pneumoniae were the significant co-infecting agents. The antibiogram demonstrated multidrug resistance in a majority of the isolates. Relative risk associated with ventilator, diabetes, and surgery was higher in repeat isolates than in first isolates and were multidrug resistant. Repeat isolates were more resistant that the first isolates to most anti-acinetobacter agents, but the overall crude mortality was not significant during this study period, and couldn't correlated to the choice of treatment. In conclusion, a resistance against all clinically used carbapenems, and colistin is rapidly increasing in repeat isolates of A. baumannii; leaves narrow therapeutic options to treat multidrug-resistant and pandrug-resistant A. baumannii infection. For the first time we report rising incidence of colistin resistance by 20 percent in repeat isolates, and is worrisome for healthcare centers. A combination therapy should be adopted to treat such infection to avoid the emergence of colistin-resistant phenotypes in the United States.

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“…baumannii FTIR spectra in the 1500-900 cm À1 region processed with SNV and Savitzky-Golay is also a matter of concern [2][3][4]. A comprehensive view of multidrug resistant A. baumannii population dynamics is then essential to develop better strategies to restrict its further expansion.…”

Section: Introductionmentioning

confidence: 99%

Identification of carbapenem‐resistant Acinetobacter baumannii clones using infrared spectroscopy

Sousa

Grosso

Meirinhos-Soares³

et al. 2012

Journal of Biophotonics

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In this work we assessed the discriminatory ability of Fourier‐transform Infrared Spectroscopy (FTIR) in 22 representative isolates from a collection of 318 carbapenem‐hydrolyzing class D β ‐lactamases (CHDL)‐producing Acinetobacter spp. (5 hospitals; 2001–2008) previously characterized by DNA‐based typing methods. FTIR spectra were acquired with a Bruker spectrometer and analyzed with support of several chemometric tools. The results showed that FTIR spectroscopy was able to distinguish the main CHDL‐producing Acinetobacter baumannii lineages causing infection in Portugal, the ST103 carrying blaOXA‐58, ST98 carrying blaOXA‐24/40and ST92 carrying blaOXA‐23. Moreover, this study revealed distinctive phenotypic features of A. baumannii lineages causing infections that might justify different epidemic potential. Spectroscopy may arise as a low cost and easily to perform alternative for typing A. baumannii isolates. (© 2014 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)

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Extensively drug-resistant Acinetobacter baumannii: risk factors for acquisition and prevalent OXA-type carbapenemases—a multicentre study

Cited by 35 publications

References 34 publications

Types and Prevalence of Carbapenem-Resistant Acinetobacter calcoaceticus-Acinetobacter baumannii Complex in Northern Taiwan

Types and Prevalence of Carbapenem-Resistant Acinetobacter calcoaceticus-Acinetobacter baumannii Complex in Northern Taiwan

Patient Demographics and Characteristics of Infection with Carbapenem-Resistant <i>Acinetobacter baumannii</i> in a Teaching Hospital from the United States

Identification of carbapenem‐resistant Acinetobacter baumannii clones using infrared spectroscopy

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Extensively drug-resistant Acinetobacter baumannii: risk factors for acquisition and prevalent OXA-type carbapenemases—a multicentre study

Cited by 35 publications

References 34 publications

Types and Prevalence of Carbapenem-Resistant Acinetobacter calcoaceticus-Acinetobacter baumannii Complex in Northern Taiwan

Types and Prevalence of Carbapenem-Resistant Acinetobacter calcoaceticus-Acinetobacter baumannii Complex in Northern Taiwan

Patient Demographics and Characteristics of Infection with Carbapenem-Resistant &lt;i&gt;Acinetobacter baumannii&lt;/i&gt; in a Teaching Hospital from the United States

Identification of carbapenem‐resistant Acinetobacter baumannii clones using infrared spectroscopy

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Patient Demographics and Characteristics of Infection with Carbapenem-Resistant <i>Acinetobacter baumannii</i> in a Teaching Hospital from the United States