Extensive transgressive gene expression in testis but not ovary in the homoploid hybrid Italian sparrow

Yazdi, Homa Papoli; Ravinet, Mark; Rowe, Melissah; Sætre, Glenn‐Peter; Guldvog, Caroline Ø; Eroukhmanoff, Fabrice; Marzal, Alfonso; Magallanes, Sergio; Runemark, Anna

doi:10.1111/mec.16572

Cited by 8 publications

(7 citation statements)

References 65 publications

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“…Functional analyses suggested that these patterns derive from incompatibilities between mitochondrial and nuclear genomes in hybrids. Similar results have been reported in other studies 22 , 73 – 76 and these findings could open an exciting new area of research in thrushes. Specifically, there is considerable interest in the role mitonuclear incompatibilities play in speciation 77 , 78 .…”

Section: Discussionsupporting

confidence: 91%

“…Reductions in the cognitive abilities of hybrids could represent the downstream effects of transgressive expression (and mitonuclear incompatibilities) in this brain region 82 . Studies of transgressive expression rarely include behavioral contrasts; most work is limited to constitutive patterns 70 , 76 , 83 or comparisons between sterile and fertile hybrids 73 , 84 . Our study highlights the role context-dependent transgressive expression could play in speciation and we look forward to future work on this connection in the Swainson’s thrush and other systems.…”

Section: Discussionmentioning

confidence: 99%

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Gene regulation and speciation in a migratory divide between songbirds

Louder,

Justen,

Kimmitt

et al. 2024

Nat Commun

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Behavioral variation abounds in nature. This variation is important for adaptation and speciation, but its molecular basis remains elusive. Here, we use a hybrid zone between two subspecies of songbirds that differ in migration – an ecologically important and taxonomically widespread behavior---to gain insight into this topic. We measure gene expression in five brain regions. Differential expression between migratory states was dominated by circadian genes in all brain regions. The remaining patterns were largely brain-region specific. For example, expression differences between the subspecies that interact with migratory state likely help maintain reproductive isolation in this system and were documented in only three brain regions. Contrary to existing work on regulatory mechanisms underlying species-specific traits, two lines of evidence suggest that trans- (vs. cis) regulatory changes underlie these patterns – no evidence for allele-specific expression in hybrids and minimal associations between genomic differentiation and expression differences. Additional work with hybrids shows expression levels were often distinct (transgressive) from parental forms. Behavioral contrasts and functional enrichment analyses allowed us to connect these patterns to mitonuclear incompatibilities and compensatory responses to stress that could exacerbate selection on hybrids and contribute to speciation.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Gene regulation and speciation in a migratory divide between songbirds

Louder,

Justen,

Kimmitt

et al. 2024

Nat Commun

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“…Yazdi et al. (2022) were the first to show transgressive gene expression in a natural homoploid hybrid zone. Earlier work on transgressive expression had all been done with allopolyploids, and most work on transgressive phenotypes (gene expression and others) in hybrids has focused on early generation hybrids, particularly F 1 and F 2 .…”

Section: Introductionmentioning

confidence: 99%

“…Transgressive gene expression has been studied extensively in polyploid plants for agricultural purposes (Gallego-Tévar et al, 2018), but recent studies have shown it occurs in animals as well (Wang et al, 2022;Yazdi et al, 2022). Yazdi et al (2022) were the first to show transgressive gene expression in a natural homoploid hybrid zone. Earlier work on transgressive expression had all been done with allopolyploids, and most work on transgressive phenotypes (gene expression and others) in hybrids has focused on early generation hybrids, particularly F 1 and F 2 .…”

mentioning

confidence: 99%

“…It has also been suggested that gene expression plasticity could be important for species to adapt to climate change (Kelly, 2019), however climate imposed selection can potentially reduce that plasticity (Kelly et al, 2017). Transgressive gene expression has been studied extensively in polyploid plants for agricultural purposes (Gallego-Tévar et al, 2018), but recent studies have shown it occurs in animals as well (Wang et al, 2022;Yazdi et al, 2022). Yazdi et al (2022) were the first to show transgressive gene expression in a natural homoploid hybrid zone.…”

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confidence: 99%

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Transgressive gene expression and expression plasticity under thermal stress in a stable hybrid zone

Schwartz,

González,

Strong

et al. 2024

Molecular Ecology

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Interspecific hybridization can lead to myriad outcomes, including transgressive phenotypes in which the hybrids are more fit than either parent species. Such hybrids may display important traits in the context of climate change, able to respond to novel environmental conditions not previously experienced by the parent populations. While this has been evaluated in an agricultural context, the role of transgressive hybrids under changing conditions in the wild remains largely unexplored; this is especially true regarding transgressive gene expression. Using the blue mussel species complex (genus Mytilus) as a model system, we investigated the effects of hybridization on temperature induced gene expression plasticity by comparing expression profiles in parental species and their hybrids following a 2‐week thermal challenge. Hybrid expression plasticity was most often like one parent or the other (50%). However, a large fraction of genes (26%) showed transgressive expression plasticity (i.e. the change in gene expression was either greater or lesser than that of both parent species), while only 2% were intermediately plastic in hybrids. Despite their close phylogenetic relationship, there was limited overlap in the differentially expressed genes responding to temperature, indicating interspecific differences in the responses to high temperature in which responses from hybrids are distinct from both parent species. We also identified differentially expressed long non‐coding RNAs (lncRNAs), which we suggest may contribute to species‐specific differences in thermal tolerance. Our findings provide important insight into the impact of hybridization on gene expression under warming. We propose transgressive hybrids may play an important role in population persistence under future warming conditions.

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Morphology and morphometry of two hybridizing buntings at their hybrid zone in northern Iran reveal intermediate and transgressive morphotypes

Gholamhosseini,

Aliabadian,

Töpfer

et al. 2023

Avian Research

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Extensive transgressive gene expression in testis but not ovary in the homoploid hybrid Italian sparrow

Abstract: Hybridization between recently diverged species is an important evolutionary phenomenon resulting in novel gene combinations that become available to selection (

Cited by 8 publications

References 65 publications

Gene regulation and speciation in a migratory divide between songbirds

Gene regulation and speciation in a migratory divide between songbirds

Transgressive gene expression and expression plasticity under thermal stress in a stable hybrid zone

Morphology and morphometry of two hybridizing buntings at their hybrid zone in northern Iran reveal intermediate and transgressive morphotypes

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