Wireless communications are among the rapidly growing fields in our current life and have a massive effect on every aspect of our everyday life. In this paper, the performance of the various digital modulation techniques (BPSK, DPSK, QPSK, and QAM)
based wireless communication system on the audio signal transmission through the additive Gaussian Noise (AWGN) channel is assessed on the basis of bit error rate (BER) as a function of the signal-to-noise ratio (SNR). Based on the results of this study, BPSK modulation outperforms the DPSK, QPSK, and QAM modulation strategies in the MIMO MC-CDMA V-Blast based wireless communication system. The digital modulation of QPSK shows the worst performance in audio signal transmission especially in comparison to other digital modulations. It is clear from the current simulation study based on MATLAB that the V-Blast encoded 4×4 MIMO MC-CDMA wireless system with minimum mean square error (MMSE) signal detection and 1⁄2-rated convolution and cyclic redundancy check (CRC) channel encoding strategies show good performance utilizing BPSK digital modulation in audio signal transmission.