Extensive Diffuse Pulmonary Ossification

Fried, Ethan D.; Godwin, Thomas

doi:10.1378/chest.102.5.1614

Cited by 39 publications

(24 citation statements)

References 6 publications

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“…Travis et al reported that metaplastic bone formation was seen in 21% of usual interstitial pneumonia [30]. The other report suggested that any fibrosis was a precursor of diffuse pulmonary ossification [3]. The collapsed fibrosis pattern in the present study has the same histological characteristics as racemose or branching type based on the shape of bone present in the fibrotic stroma.…”

Section: Discussionsupporting

confidence: 62%

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Clinicopathological analysis of primary lung carcinoma with heterotopic ossification

Kuribayashi

Tsuta²,

Mizutani

et al. 2009

Lung Cancer

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Section: Discussionsupporting

confidence: 62%

“…Fried and Goodwin suggested that any fibrosis in the lung parenchyma is a precursor of diffuse pulmonary ossification [3]. Focal pulmonary ossification is described as being associated with pulmonary tuberculosis or with pulmonary tumors.…”

Section: Introductionmentioning

confidence: 99%

Clinicopathological analysis of primary lung carcinoma with heterotopic ossification

Kuribayashi

Tsuta²,

Mizutani

et al. 2009

Lung Cancer

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“…Nodular circumscribed ossification is often associated with mitral stenosis. For dendriform ossification, the less common type, an association with pulmonary interstitial fibrosis has been suggested [2][3][4][5][6][7]. Although disseminated dendriform pulmonary ossification has been well described histopathologically [2][3][4][5][6][7][8][9][10], only a few reports of its radiologic findings have been published [8,11,12].…”

Section: Introductionmentioning

confidence: 99%

Disseminated dendriform pulmonary ossification associated with usual interstitial pneumonia: incidence and thin-section CT–pathologic correlation

et al. 2005

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The aim of this work was to assess the incidence of disseminated pulmonary dendriform ossification in usual interstitial pneumonia and nonspecific interstitial pneumonia, and to correlate thin-section computed tomography (CT) and histopathologic findings. We retrospectively reviewed thin-section CT and pathologic specimens of biopsy-proven usual interstitial pneumonia (75 patients, 57 men and 18 women, mean age 60 years, range 29-83 years) and nonspecific interstitial pneumonia (44 patients, 9 men and 35 women, mean age 55 years, range 20-73 years). On review of CT and histopathologic specimens, diffuse dendriform ossification was identified in five (four men and one woman, age range 41-68 years, mean 58 years) of 75 patients (6.7%) with usual interstitial pneumonia. It was not seen in any of 44 patients with nonspecific interstitial pneumonia. With thin-section CT (osteoporosis window; window width 818, level 273), disseminated dendriform pulmonary ossification was detected as multiple tiny calcifications in bibasilar subpleural lungs (100% sensitive and 100% specific when compared with histopathologic findings as the gold standard). The thin-section CT finding of multiple tiny calcifications in bibasilar subpleural lungs might be of some help in the differential diagnosis between usual interstitial pneumonia and nonspecific interstitial pneumonia, considering they were not seen in any patients with nonspecific interstitial pneumonia (0%, 0/44) in our series.

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“…The diffuse form can be further subdivided into 2 histological subtypes: the dendriform type, the less common of the 2, and nodular pulmonary ossification (NPO) [1] . Both are usually diagnosed at autopsy [2] , while antemortem detection is rare. In this case the diagnosis, established by transbronchial biopsy, was of a localised form of DPO in the lateral segment of the middle lobe.…”

Section: Discussionmentioning

confidence: 99%