“…The purine-pyrimidine base pairs in DNA contain aminopyrimidine and amide groups (adenine-thymine/guanine-cytosine), which are predominantly bound by hydrogen bond interactions. 7,8 Likewise, structures similar to nucleobases interact with various drugs and solvent molecules through hydrogen bond interactions. 9 In addition, aminopyrimidine interactions with carboxylic acids are biologically important for recognizing nucleic acid-protein and protein-drug combinations.…”