Extension of weight-standardized bone mineral content in osteoporosis diagnosis

Zhou, Li; Peng, Feng-Lin

doi:10.1097/cm9.0000000000000471

Cited by 1 publication

(1 citation statement)

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“…This finding is in line with a recent large-sample Chinese study, in which they found that considering a standardized BMC after adjustment by body weight has led to a decrease in the number of missed diagnoses in patients with a large body weight (i.e., obesity) and reducing misdiagnosis in those with a smaller body weight (i.e., normal-weight individuals) [24]. Therefore, they concluded that BMC adjustment by body weight is always needed to avoid the over-or underestimation of the diagnosis of osteoporosis, and consideration of the BMD or BMC values may lead to misclassification bias [33].…”

Section: Findings and Concordance With Previous Studiesmentioning

confidence: 99%

The Association between Obesity and Reduced Weight-Adjusted Bone Mineral Content in Older Adults: A New Paradigm That Contrasts with the Obesity Paradox

De Lorenzo,

Pellegrini,

Gualtieri

et al. 2024

Nutrients

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The relationship between body weight and bone mass in the elderly remains unclear, and whether obesity is a protective factor is still a matter of debate. For this reason, the aim of this study is to assess the association between body mass index (BMI) and bone mineral content adjusted by body weight, expressed as a percentage (w-BMC%), and to test the validity of the obesity paradox in this context. A cohort of 1404 older adults was categorized according to the World Health Organization’s BMI cut-off points and completed a total and segmental body composition measurement by means of a dual X-ray absorptiometry scan. Individuals with obesity displayed a lower mean w-BMC% (3.06 ± 0.44%; 2.60 ± 0.37%) compared to those who were normal-weight (3.95 ± 0.54%; 3.38 ± 0.48%) and overweight (3.06 ± 0.44%; 3.04 ± 0.37%) in both genders. Linear regression analysis also showed a negative association between BMI and w-BMC% in males (β = −0.09; p < 0.001) and females (β = −0.06; p < 0.001). Finally, among individuals with obesity, and after adjusting for age, the linear regression models revealed a significant decrease of 0.75% and 0.28% in w-BMC% for every one-unit increase in the trunk fat/appendicular lean mass ratio in both males (β = −0.749; p < 0.0001) and females (β = −0.281; p < 0.001). In conclusion, we suggest a new paradigm regarding the impact of obesity on bone mass, in which the former does not appear to be a protective factor of the latter, especially in individuals with central obesity and low muscle mass.

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Section: Findings and Concordance With Previous Studiesmentioning

confidence: 99%