“…At present, pharmaceutical companies and experimental centers are carrying out the development of antibiotics ( Hutchings et al, 2019 ), and 45 drugs are being tested, among which there are also categories of new modes of action. In the future, it is necessary to use computer simulation calculation, which is similar to the research of epidemic diseases ( Chen et al, 2021 ; Wieland and Mercorelli, 2021 ). For example, through the computer simulation of targeting combined with bacterial modeling, in vitro activity of antibiotic molecules, safety screening, in vitro antibacterial activity of clinical strains and other screening processes, the best bactericidal mechanism will be finally determined, and a series of antibiotics suitable for orthopedic treatment will be designed to form a new antibiotic library.…”