Extending the socio-sexual brain: arginine-vasopressin immunoreactive circuits in the telencephalon of mice

Otero-García, Marcos; Martín‐Sánchez, Ana; Fortes-Marco, Lluis; Martínez‐Ricós, Joana; Agustín-Pavón, Carmen; Lanuza, Enrique; Martínez‐Garciá, Fernando

doi:10.1007/s00429-013-0553-3

Cited by 31 publications

(50 citation statements)

References 95 publications

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“…Likewise, and in spite of the sexually dimorphic distribution of AVP (Rood et al 2013;Otero-Garcia et al 2014), the distribution of cells and fibres in which AVP ? OT are co-localized was similar in the two males and two females analysed.…”

Section: Resultsmentioning

confidence: 99%

“…There, OT-ir fibres also show quite a variable distribution pattern among individuals, abundant in some specimens while almost absent in others. This recalls the distribution of AVP-ir fibres in the same nucleus (Otero-Garcia et al 2014), an issue that will be discussed below. Our results in mice do not fit those by Knobloch et al (2012) in rats, as we did not notice differences in the morphology and density of OT-ir fibres in the CeM, CeL and CeC of mice.…”

Section: Distribution Of Ot-immunoreactive Processesmentioning

confidence: 95%

“…As discussed by Otero-Garcia et al (2014), a comparison of the distribution of the OT/AVP receptors and nonapeptidergic innervation evidences a certain level of mismatch between the pre-and post-synaptic elements. Such mismatches can be attributed to receptor promiscuity, but also to extra-synaptic slow signalling through volume transmission.…”

Section: Introductionmentioning

confidence: 92%

“…In fact, a majority of the OT-ir somata in the rostral edge of the PaAP and in the AC/ ADP show also weak-to-moderate AVP immunoreactivity. In the AC/ADP, Rood et al (2013) and Otero-Garcia et al (2014) described an AVP-ir cell group, different from the sexually dimorphic AVP-ir population of the BSTMP. Our present results suggest that the OT-ir and AVP-ir groups next to the anterior commissure correspond in fact to a single AC/ADP population of cells that are immunolabelled for both peptides.…”

Section: Distribution Of Nonapeptidergic Cells Co-expressing Ot and Avpmentioning

confidence: 99%

“…However, neuroanatomical data are fragmentary and scarce in mice, as compared to rats. Concerning nonapeptides, several good descriptions of the distribution of AVP have recently been published (Rood and de Vries 2011;Rood et al 2013;Otero-Garcia et al 2014). However, OT distribution was only described by Castel and Morris (1988) using immunohistochemistry for the accompanying neurophysin (type I).…”

Section: Introductionmentioning

confidence: 99%

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Distribution of oxytocin and co-localization with arginine vasopressin in the brain of mice

et al. 2015

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Oxytocin (OT) and vasopressin (AVP) play a major role in social behaviours. Mice have become the species of choice for neurobiology of social behaviour due to identification of mouse pheromones and the advantage of genetically modified mice. However, neuroanatomical data on nonapeptidergic systems in mice are fragmentary, especially concerning the central distribution of OT. Therefore, we analyse the immunoreactivity for OT and its neurophysin in the brain of male and female mice (strain CD1). Further, we combine immunofluorescent detection of OT and AVP to locate cells co-expressing both peptides and their putative axonal processes. The results indicate that OT is present in cells of the neurosecretory paraventricular (Pa) and supraoptic hypothalamic nuclei (SON). From the anterior SON, OTergic cells extend into the medial amygdala, where a sparse cell population occupies its ventral anterior and posterior divisions. Co-expression of OT and AVP in these nuclei is rare. Moreover, a remarkable OTergic cell group is found near the ventral bed nucleus of the stria terminalis (BST), distributed between the anterodorsal preoptic nucleus and the nucleus of anterior commissure (ADP/AC). This cell group, the rostral edge of the Pa and the periventricular hypothalamus display frequent OT + AVP double labelling, with a general dominance of OT over AVP immunoreactivity. Fibres with similar immunoreactivity profile innervate the accumbens shell and core, central amygdala and portions of the intervening BST. These data, together with data in the literature on rats, suggest that the projections of ADP/AC nonapeptidergic cells onto these brain centres could promote pup-motivated behaviours and inhibit pup avoidance during motherhood.

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Section: Resultsmentioning

confidence: 99%

Section: Distribution Of Ot-immunoreactive Processesmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 92%

Section: Distribution Of Nonapeptidergic Cells Co-expressing Ot and Avpmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Distribution of oxytocin and co-localization with arginine vasopressin in the brain of mice

et al. 2015

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Afferent and efferent projections of the anterior cortical amygdaloid nucleus in the mouse

Cádiz-Moretti

Abellán-Álvaro

Pardo-Bellver

et al. 2017

J of Comparative Neurology

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The anterior cortical amygdaloid nucleus (ACo) is a chemosensory area of the cortical amygdala that receives afferent projections from both the main and accessory olfactory bulbs. The role of this structure is unknown, partially due to a lack of knowledge of its connectivity. In this work, we describe the pattern of afferent and efferent projections of the ACo by using fluorogold and biotinylated dextranamines as retrograde and anterograde tracers, respectively. The results show that the ACo is reciprocally connected with the olfactory system and basal forebrain, as well as with the chemosensory and basomedial amygdala. In addition, it receives dense projections from the midline and posterior intralaminar thalamus, and moderate projections from the posterior bed nucleus of the stria terminalis, mesocortical structures and the hippocampal formation. Remarkably, the ACo projects moderately to the central nuclei of the amygdala and anterior bed nucleus of the stria terminalis, and densely to the lateral hypothalamus. Finally, minor connections are present with some midbrain and brainstem structures. The afferent projections of the ACo indicate that this nucleus might play a role in emotional learning involving chemosensory stimuli, such as olfactory fear conditioning. The efferent projections confirm this view and, given its direct output to the medial part of the central amygdala and the hypothalamic 'aggression area', suggest that the ACo can initiate defensive and aggressive responses elicited by olfactory or, to a lesser extent, vomeronasal stimuli.

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Variation of pro‐vasopressin processing in parvocellular and magnocellular neurons in the paraventricular nucleus of the hypothalamus: Evidence from the vasopressin‐related glycopeptide copeptin

Kawakami

Otubo

Maejima

et al. 2020

J of Comparative Neurology

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Arginine vasopressin (AVP) is synthesized in parvocellular-and magnocellular neuroendocrine neurons in the paraventricular nucleus (PVN) of the hypothalamus. Whereas magnocellular AVP neurons project primarily to the posterior pituitary, parvocellular AVP neurons project to the median eminence (ME) and to extrahypothalamic areas. The AVP gene encodes pre-pro-AVP that comprises the signal peptide, AVP, neurophysin (NPII), and a copeptin glycopeptide. In the present study, we used an N-terminal copeptin antiserum to examine copeptin expression in magnocellular and parvocellular neurons in the hypothalamus in the mouse, rat, and macaque monkey. Although magnocellular NPII-expressing neurons exhibited strong N-terminal copeptin immunoreactivity in all three species, a great majority (90%) of parvocellular neurons that expressed NPII was devoid of copeptin immunoreactivity in the mouse, and in approximately half (53%) of them in the rat, whereas in monkey hypothalamus, virtually all NPII-immunoreactive parvocellular neurons contained strong copeptin immunoreactivity. Immunoelectron microscopy in the mouse clearly showed copeptin-immunoreactivity co-localized with NPII-immunoreactivity in Natsuko Kawakami and Akito Otubo contributed equally to this work.

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Extending the socio-sexual brain: arginine-vasopressin immunoreactive circuits in the telencephalon of mice

Cited by 31 publications

References 95 publications

Distribution of oxytocin and co-localization with arginine vasopressin in the brain of mice

Distribution of oxytocin and co-localization with arginine vasopressin in the brain of mice

Afferent and efferent projections of the anterior cortical amygdaloid nucleus in the mouse

Variation of pro‐vasopressin processing in parvocellular and magnocellular neurons in the paraventricular nucleus of the hypothalamus: Evidence from the vasopressin‐related glycopeptide copeptin

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