Extended surgical resection in T4 gastric cancer

Shchepotin, I.; Chorny, Vyacheslav A.; Nauta, Russell J.; Shabahang, Mohsen; Buras, R.; Evans, Stephen

doi:10.1016/s0002-9610(97)00268-7

Cited by 72 publications

(73 citation statements)

References 18 publications

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“…After removal of duplicates and screening for relevant titles and abstracts, a total of 142 articles were submitted for a full-text review. Seventeen studies involving 1343 patients met our inclusion criteria and were included in this review [1,2,[4][5][6][8][9][10][11][12][13][14][15][16][17][18][19][20] (Fig. 1).…”

Section: Literature Searchmentioning

confidence: 99%

Multivisceral resection for gastric cancer: a systematic review

et al. 2011

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Background The overall prognosis and survival of patients with advanced gastric cancer is generally poor. One of the most powerful predictors of outcomes in gastric cancer surgery is an R0 resection. However, the extent of the required surgical resection and the additional benefit of multivisceral resection (MVR) are controversial. Methods Electronic literature searches were conducted using Medline, EMBASE, and the Cochrane Central Register of Controlled Trials from

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Section: Literature Searchmentioning

confidence: 99%

Multivisceral resection for gastric cancer: a systematic review

et al. 2011

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“…However, some patients treated by radical surgery can survive for a long time after surgery [2]. There were several studies [3][4][5][6] in which the resection of invaded organs with gastrectomy was recommended for T4 gastric cancer to achieve a better prognosis for these patients. However, the clinical efficacy of these radical operations has remained unclear.…”

Section: Introductionmentioning

confidence: 99%

Prognostic factors in patients with advanced gastric cancer with macroscopic invasion to adjacent organs treated with radical surgery

et al. 2000

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“…In literature, the morbidity and mortality rates for locally advanced gastric cancer surgery changes between 25-30% and 5-10% respectively (31,32). The mortality rate for earlier stages of gastric cancer is 2-3% (13).…”

Section: Discussionmentioning

confidence: 99%

Surgical Outcomes and Early Postoperative Complications in Locally Advanced Gastric Cancer

Doğan¹,

Karaman²,

Hüseyinova³

et al. 2011

Acta Oncol Tur.

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ÖZET Amaç: Batı ülkelerinde saptanan mide kanserlerinin %60-65'i tanı anında lokal ileri evrededirler. Bu hastalara uygulanan genişletilmiş rezeksiyonlar komplikasyon riskini arttırabilir. Bu çalışmanın amacı lokal ileri evre mide kanserlerinde rezektabilite, erken dönem mortalite ve morbidite oranlarını saptamaktır. Hastalar ve Yöntem: Ocak 2002 ile Eylül 2006 tarihleri arasında rezeksiyon uygulanan non-metastatik, lokal ileri evre mide kanserli hastalarımız geriye dönük olarak incelendi. Bulgular: Komşu organ invazyonu nedeni ile 110 hastaya (%49.8) ek organ rezeksiyonu uygulanmıştı. Yüz seksen bir hastaya (%82) R0, 29 hastaya (%13) R1 ve 11 hastaya (%5) R2 rezeksiyon yapılabilmişti. Tüm serinin morbidite ve mortalite oranları sırasıyla %21.7 ve %4.5 olarak bulundu. İkiden fazla ek organ rezeksiyonu (p=0.001), 2 üniteden fazla kan transfüzyonu (p=0.001) ve düşük protein seviyeleri (p=0.008) multivaryant analizlerde komplikasyon oranlarını arttıran parametreler olarak saptandı. İki veya daha fazla ek organ rezeksiyonu (p=0.001), kardiyovasküler ve respiratuar komorbidite (p=0.002) ve total gastrektomi uygulanması (p=0.028) mortaliteyi arttıran faktörler olarak bulundu. Sonuç: Neo-adjuvan tedavi uygulanmayan lokal ileri evre mide kanserli hastalarda ek organ rezeksiyonu oranları yüksektir ve bu durum morbidite ve mortalite oranlarını arttırır. Total gastrektomi mortaliteyi arttıran bir faktör olarak belirlenmiş ancak D2 diseksiyonun bu hastalarda güvenle uygulanabileceği sonucuna varılmıştır. Anahtar kelimeler: Komplikasyon; Lokal ileri evre mide kanseri; Morbidite; Mortalite ABSTRACT Objective: In Western world, 60 to 65% of the gastric cancer cases are in locally advanced stage at the time of diagnosis. Extended resections may increase the risk of complications in these patients. The aim of this study was to investigate the resectability, early morbidity and mortality rates for locally advanced gastric cancer. Patients and Methods: Non-metastatic locally advanced gastric cancer patients who underwent resection between January 2002 and September 2006 were analyzed retrospectively. Results: One hundred and ten patients (49.8%) had additional organ resection due to adjacent organ involvement. R0 resection was performed in 181 patients (82%), R1 resection in 29 patients (13%), and R2 resection in 11 patients (5%). The morbidity and mortality rates of the all series were 21.7% and 4.5% respectively. According to multivariate analysis more than two additional organ resections (p=0.001), erythrocyte transfusions of more than 2 units (p=0.001) and low total protein levels (p=0.008) were determined as the parameters that increase complication rates. The parameters that increase mortality rates were as follows; having two or more additional organ resections (p=0.001), cardiovascular and respiratory comorbidities (p=0.002) and total gastrectomy (p=0.028). Conclusion: Additional organ resection rate of the patients with locally advanced gastric cancers that not given neo-adjuvant treatment is high and this occurrence incr...

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Extended surgical resection in T4 gastric cancer

Cited by 72 publications

References 18 publications

Multivisceral resection for gastric cancer: a systematic review

Multivisceral resection for gastric cancer: a systematic review

Prognostic factors in patients with advanced gastric cancer with macroscopic invasion to adjacent organs treated with radical surgery

Surgical Outcomes and Early Postoperative Complications in Locally Advanced Gastric Cancer

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