Extended-spectrum β-lactamase-mediated third-generation cephalosporin resistance in Shigella isolates in Bangladesh

Rahman, Mahbubur; Shoma, Shereen; Rashid, Harunur; Siddique, A. K.; Nair, G. Balakrish; Sack, David A.

doi:10.1093/jac/dkh413

Cited by 43 publications

(35 citation statements)

References 6 publications

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“…The MIC for azithromycin-resistant S. flexneri type 3b (NK2788) and S. boydii type 1 (G24371) was 192 and 128 mg ml 21 , respectively. None of the other Shigella strains proved to be resistant to azithromycin and ceftriaxone, in contrast to a recent report from Bangladesh of resistance to these agents among Shigella species (Rahman et al, 2004).…”

Section: Resultscontrasting

confidence: 97%

Molecular characterization of multidrug-resistant Shigella species isolated from epidemic and endemic cases of shigellosis in India

Pazhani

Niyogi

Singh

et al. 2008

Journal of Medical Microbiology

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Shigella species represent one of the growing numbers of antimicrobial-resistant bacteria in developing countries. Fluoroquinolone-resistant strains of Shigella dysenteriae type1 and Shigella flexneri type 2a emerged in India during 2002 and 2003, respectively. Sixty strains of Shigella from different parts of India were analysed for antimicrobial susceptibility, the presence of the qnr plasmid, mutations in the quinolone resistance determining regions (QRDRs), fluoroquinolone accumulation, and the presence of other genes encoding resistance to various antimicrobials. Fluoroquinolone-resistant strains had mutations in gyrA and parC genes and had an active efflux system. They were also resistant to several other antimicrobials but were susceptible to azithromycin and ceftriaxone. The majority of the strains harboured genes encoding resistance to ampicillin (97 %), tetracycline (95 %), streptomycin (95 %) and chloramphenicol (94 %). PFGE analysis revealed clonality among strains of S. dysenteriae types 1 and 5, S. flexneri type 2a and Shigella boydii type 12. INTRODUCTIONShigellosis remains an important public health problem in developing countries with Shigella sonnei in Europe and the US and Shigella flexneri in Asian and African countries being of epidemiological importance. Antimicrobial therapy is advocated for shigellosis to shorten the duration of illness (Salam & Bennish, 1991). However, in Asia and Africa, antimicrobial resistance is an emerging problem among Shigella species (von Seidlein et al., 2006) and treatment options are becoming limited globally (Salam & Bennish, 1991;Kariuki & Hart, 2001). The World Health Organization has recommended that ciprofloxacin should be considered a first-line antibiotic for the treatment of shigellosis, and the use of nalidixic acid is not encouraged, even in areas where it is still effective against Shigella (WHO, 2004). Similar to the prevalence of different serotypes, antimicrobial-resistance patterns of strains also differ from country to country and even within the same country (Pazhani et al., 2005;von Seidlein et al., 2006), which may be due to the spread of resistant clones as found for multidrug-resistant strains of Shigella dysenteriae type 1 in eastern parts of India (Pazhani et al., 2004). In this study, we have investigated the mechanisms of antibiotic resistance and clonal relatedness of Shigella strains isolated from epidemic and endemic cases of shigellosis in different parts of India. METHODSBacterial strains. We examined 60 strains of Shigella species (20 S. dysenteriae, 16 S. flexneri, 7 Shigella boydii and 17 S. sonnei) isolated from dysentery outbreaks from different parts of India and sporadic hospitalized cases of shigellosis in Kolkata and Goa between 2001 and 2004. Strains were confirmed as Shigella spp. by standard biochemical tests (WHO, 1987) and serotyped using commercially available antisera (Denka Seiken).Antimicrobial susceptibility testing. Antimicrobial susceptibility tests were performed by a disc diffusion method in accordance with...

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Section: Resultscontrasting

confidence: 97%

Molecular characterization of multidrug-resistant Shigella species isolated from epidemic and endemic cases of shigellosis in India

Pazhani

Niyogi

Singh

et al. 2008

Journal of Medical Microbiology

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“…Since that time many strains of Shigella spp. harbouring different types of ESBLs have been reported in developed and developing countries in Asia (Cheung et al, 2005;Chuang et al, 2006;Kim et al, 2004;Pai et al, 2001;Rahman et al, 2004;Xiong et al, 2007). However, to the best of our knowledge this is the first report of ESBLproducing Shigella spp.…”

Section: Rapid Emergence Of Third Generation Cephalosporin Resistant mentioning

confidence: 78%

Rapid emergence of third generation cephalosporin resistant Shigella spp. in Southern Vietnam

Vinh

Baker

Campbell

et al. 2009

Journal of Medical Microbiology

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“…In Bangladesh, 3GC resistance was first reported in Shigella isolates in Dhaka during [2001][2002] and that time the increased MIC of ciprofloxacin was documented in the same report (Rahman et al, 2004). Afterward, in 2013 we reported that Neisseria gonorrhea isolated from sex workers were ciprofloxacin resistant (Nesa et al, 2013) but in another study, we showed ciprofloxacin sensitivity to uropathogen Proteus isolated from municipally supplied water (Chouduri and Wadud, 2014).…”

Section: Discussionmentioning

confidence: 69%

Cephalosporin-3G, Highly Prescribed Antibiotic to Outpatients in Rajshahi, Bangladesh: Prescription Errors, Carelessness, Irrational Uses are the Triggering Causes of Antibiotic Resistance

2018

J App Pharm Sci

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The study aims to assess the prescribing practices of antibiotics to outpatients attending public-private hospitals in Bangladesh and to investigate how the irrational uses of antibiotics influence the development of antimicrobial resistance in pathogens over time. A cross-sectional survey was conducted on 1100 prescriptions by interviewing outpatients at the exit point and at retail pharmacies. Infections in male patients (67%) were greater than female (32%). Unexpectedly 22% of patients visited quack doctors (unauthorized doctors), 32% did not complete antibiotic courses, and 10% took multiple antibiotics. As prescription errors the directions for antibiotic use were incomplete in 40% of cases and in a few cases, dosage form information was incomplete (17%) and absent (5%). The disease recovery rate was 12%, although no diagnostic test was performed in the majority (73%) of cases and no comments about disease recovery were in 81% cases. Post-operative infection was commonly found which could preferably be treated with rarely used antibiotics of DNA-or protein-synthesis inhibitors. Rarely used antibiotics (0.18-2% of prescribed antibiotics) were 1GCs, amoxicillin, co-amoxiclav, gatifloxacin, pefloxacin, and sparfloxacin. Most frequently prescribed antibiotics were cephalosporins (34%) followed by quinolones (16%), metronidazole (15%), macrolides (13%) and penicillins (7%). 3GCs (ceftriaxone, cefixime, ceftazidime), ciprofloxacin, azithromycin, and flucloxacillin were highly prescribed drugs in their respective groups. For better treatment, appropriate knowledge and practices regarding rational use of antibiotics need to be improved in patients and physician's level. Simultaneously drug authority should exercise power to control the misuse of antibiotics.

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Extended-spectrum β-lactamase-mediated third-generation cephalosporin resistance in Shigella isolates in Bangladesh

Cited by 43 publications

References 6 publications

Molecular characterization of multidrug-resistant Shigella species isolated from epidemic and endemic cases of shigellosis in India

Molecular characterization of multidrug-resistant Shigella species isolated from epidemic and endemic cases of shigellosis in India

Rapid emergence of third generation cephalosporin resistant Shigella spp. in Southern Vietnam

Cephalosporin-3G, Highly Prescribed Antibiotic to Outpatients in Rajshahi, Bangladesh: Prescription Errors, Carelessness, Irrational Uses are the Triggering Causes of Antibiotic Resistance

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