Rapid emergence of third generation cephalosporin resistant Shigella spp. in Southern Vietnam

Vinh, Ha; Baker, Stephen; Campbell, James I.; Hoàng, Nguyễn Văn Minh; Loan, Ha Thi; Chinh, Mai Thu; Anh, Vo Thi Cuc; Diep, To Song; Phuong, Le Thi; Schultsz, Constance; Farrar, Jeremy

doi:10.1099/jmm.0.002949-0

Cited by 32 publications

(32 citation statements)

References 11 publications

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“…ESBL and AmpC b-lactamase production is often associated with resistance to other classes of antimicrobials and, as a result, antimicrobial treatment of ESBLproducing isolates becomes limited (Carattoli, 2009). Dysentery caused by ESBL-and AmpC b-lactamase-producing species of the genus Shigella is seen relatively infrequently (Vinh et al, 2009). In South Africa, ESBLs have been previously identified in members of the family Enterobacteriaceae, including members of the genera Salmonella (Kruger et al, 2004) and Klebsiella (Essack et al, 2001).…”

Section: Jmm Correspondencementioning

confidence: 99%

“…Shigella flexneri serotype 2a is the predominant pathogen responsible for bacillary dysentery in developing countries (Huang et al, 2005). Due to their ability to acquire mobile genetic elements, such as resistance plasmids and transposons, species of the genus Shigella have progressively acquired resistance to antimicrobials that are used in treatment of bacillary dysentery (Vinh et al, 2009). The production of b-lactamases is one of the most effective and widespread mechanisms used by Gram-negative bacteria to circumvent the bactericidal effect of antimicrobials (Essack et al, 2001).…”

Section: Jmm Correspondencementioning

confidence: 99%

“…Molecular characterization of extended-spectrum b-lactamaseproducing Shigella isolates from humans in South Africa, 2003Africa, -2009 Bacillary dysentery is an important cause of acute diarrhoeal disease in poor communities and species of the genus Shigella are among the aetiological agents of this disease, causing an estimated 165 million infections annually with 1.1 million associated deaths (Vinh et al, 2009). Shigella flexneri serotype 2a is the predominant pathogen responsible for bacillary dysentery in developing countries (Huang et al, 2005).…”

Section: Jmm Correspondencementioning

confidence: 99%

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Molecular characterization of extended-spectrum β-lactamase-producing Shigella isolates from humans in South Africa, 2003–2009

Tau¹,

Smith

Sooka³

et al. 2012

Journal of Medical Microbiology

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Section: Jmm Correspondencementioning

confidence: 99%

Section: Jmm Correspondencementioning

confidence: 99%

Section: Jmm Correspondencementioning

confidence: 99%

See 1 more Smart Citation

Molecular characterization of extended-spectrum β-lactamase-producing Shigella isolates from humans in South Africa, 2003–2009

Tau¹,

Smith

Sooka³

et al. 2012

Journal of Medical Microbiology

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“…Studies, which investigated the use of antibiotics, recent years revealed that cephalosporins were prescribed more frequently in the treatment of infections in the world [2][3][4][5][6][7]and in Vietnam as well [8][9][10][11][12][13][14][15]. However, in the current context of antibiotic resistance crisis, particularly the burgeoning resistance to cephalosporins [16], antimicrobial stewardship programs have become a prerequisite committed at all the healthcare centers. Being aware of complicated drug resistance status, the Vietnam's government has taken urgent action to deal with this issue.…”

Section: Introductionmentioning

confidence: 99%

Injectable Cephalosporins Usein Vietnamese Hospitals:a Descriptive Cross-Sectional Multicenter Study

Nhac-Vu

Ngoc-Van²

2017

Int J Pharm Pharm Sci

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Objective: The objective of this research was to investigate the use of injectable cephalosporins for inpatients at eleven hospitals in An-Giang province, Vietnam. Methods:This cross-sectional multicenter study was conducted through retrieving the medical inpatient data at eleven hospitals in An-Giang province over the 01-12/2015 period. Results:The sample included 23155 treatment episodes with cephalosporins. Among them, 86% wereused only one agent of cephalosporins, mainly cefotaxime. Among cases administrated concurrentlydifferent antibiotic classes, combinations of cephalosporins and gentamycin were the majority. All treatment episodes correlated with sixteen indication groups of infection treatment, in which the leading groups were "pneumonia", "gastrointestinal infections" and "cesarean" according to the numbers of treatment episodesand the costs of cephalosporins used. 6.61 billion VND was spent for cephalosporins which accounted for 98 % of the total injectable antibiotic cost over the twelve-month period at eleven hospitals in An-Giang. Conclusion:Analysis of injectable cephalosporins consumption, and multicenter approach, has a crucial importance for further survey of antibiotic de-escalation protocol in hospitals in An-Giang.

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“…from many countries [5,6]. As a result of the considerable global burden, low infectious dose, clinical severity, and frequent reports of emerging antimicrobial resistance against first-line and, more recently, secondline therapies [7][8][9]. Over 70% of Shigella isolates were resistant to two or more drugs including ampicillin and co-trimoxazole during 2002 to 2007 in India [10].…”

Section: Introductionmentioning

confidence: 99%

Antibiotic Resistance Pattern of Shigella spp. Among Gastroenteritis Patients at Tertiary Care Hospital in Pokhara, Nepal

et al. 2017

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Shigellosis, a disease caused by Shigella species. It is a major public health problem in developing nations like Nepal, where communities having poverty; poor sanitation, personal hygiene, and water supplies. The main aim of our study is to isolate and identify Shigella spp. from gastroenteritis patients and to find out its drug resistance pattern. A cross-sectional study was carried out based on routinely attending outpatients and inpatients. A total of 225 stool samples collected from gastroenteritis patients were processed from 20 April to 24 September 2014 in Western Regional Hospital, Pokhara, Nepal. Standard microbiological procedures were followed for the isolation of Shigella spp. After that slide agglutination kit method was used for identification of Shigella spp. Finally, Kirby-Bauer disc diffusion method was done for an antimicrobial resistance test. Of the total 225 gastroenteritis patients, 133 were detected as bacterial positive cases. Among positive cases, Shigella spp. was identified in 10.5%. Age wise, an infection rate of Shigella in patients <15-years old was found higher i.e. 7.3% than in patients ≥ 15 years old i.e. 4.5% with the (p = 0.432) at 95% CI. The infection rate of S. dysenteriae, S. flexneri, and S. sonnei was detected in 28.6%, 57.1%, and 14.3% respectively. For the antimicrobial test, eight types of antibiotics were used. The most resistance pattern of isolated Shigella spp. was found in nalidixic acid, and co-trimoxazole 92.8% followed by ampicillin 64.3% and ciprofloxacin 42.8% etc. Our study reported that endemicity of Shigellosis with S. flexneri is the predominant group in gastroenteritis patients. This finding suggests that co-trimoxazole, nalidixic acid, ciprofloxacin and ampicillin should not be used experimentally as first-line drugs for shigellosis treatment.

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Rapid emergence of third generation cephalosporin resistant Shigella spp. in Southern Vietnam

Cited by 32 publications

References 11 publications

Molecular characterization of extended-spectrum β-lactamase-producing Shigella isolates from humans in South Africa, 2003–2009

Molecular characterization of extended-spectrum β-lactamase-producing Shigella isolates from humans in South Africa, 2003–2009

Injectable Cephalosporins Usein Vietnamese Hospitals:a Descriptive Cross-Sectional Multicenter Study

Antibiotic Resistance Pattern of Shigella spp. Among Gastroenteritis Patients at Tertiary Care Hospital in Pokhara, Nepal

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