Extended-spectrum β-lactamase (ESBL)-producing Escherichia coli isolates collected from diseased food-producing animals in the GERM-Vet monitoring program 2008–2014

Michael, Geovana Brenner; Kaspar, Heike; Siqueira, Amanda Keller; Costa, Eduardo de Freitas; Corbellini, Luís Gustavo; Kadlec, Kristina; Schwarz, Štefan

doi:10.1016/j.vetmic.2016.08.023

Cited by 47 publications

(49 citation statements)

References 33 publications

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“…A large study conducted in Germany analyzed ESBL-producing E. coli isolates collected from diseased food-producing animals in the GERM-Vet monitoring program from 2008 to 2014 (35). This study detected the gene bla CTX-M-1 in 69.9% of the ESBL producers, followed by bla CTX-M-15 in 13.6%, bla CTX-M-14 in 11.7%, bla TEM-52 in 1.9%, and bla SHV-12 in 1.4%.…”

Section: Clavulanic-acid Inhibited Class a Esblsmentioning

confidence: 99%

“…The genes bla CTX-M-3 and bla CTX-M-2 were identified in 1.0% and 0.5%, respectively. The distribution of ESBL genes varies with regard to the different animal hosts and the isolation sites; for example, ESBL-producing E. coli were isolated more frequently from cases of enteritis in calves than from cases of bovine mastitis (35). Moreover, the geographical location also plays a role.…”

Section: Clavulanic-acid Inhibited Class a Esblsmentioning

confidence: 99%

“…This clone has been rarely identified in animals and if so, mostly in companion animals (24,25,41,42). The production of various ESBLs has been demonstrated in animal E. coli isolates of a wide variety of multilocus sequence types (24,35,36,43) (Table 1). According to Ewers and colleagues, an exclusive linkage of a specific bla gene or a distinct host with a certain sequence type (ST) is not evident (24).…”

Section: Clavulanic-acid Inhibited Class a Esblsmentioning

confidence: 99%

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Antimicrobial Resistance inEscherichia coli

et al. 2018

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Multidrug resistance in has become a worrying issue that is increasingly observed in human but also in veterinary medicine worldwide. is intrinsically susceptible to almost all clinically relevant antimicrobial agents, but this bacterial species has a great capacity to accumulate resistance genes, mostly through horizontal gene transfer. The most problematic mechanisms in correspond to the acquisition of genes coding for extended-spectrum β-lactamases (conferring resistance to broad-spectrum cephalosporins), carbapenemases (conferring resistance to carbapenems), 16S rRNA methylases (conferring pan-resistance to aminoglycosides), plasmid-mediated quinolone resistance (PMQR) genes (conferring resistance to [fluoro]quinolones), and genes (conferring resistance to polymyxins). Although the spread of carbapenemase genes has been mainly recognized in the human sector but poorly recognized in animals, colistin resistance in seems rather to be related to the use of colistin in veterinary medicine on a global scale. For the other resistance traits, their cross-transfer between the human and animal sectors still remains controversial even though genomic investigations indicate that extended-spectrum β-lactamase producers encountered in animals are distinct from those affecting humans. In addition, of animal origin often also show resistances to other-mostly older-antimicrobial agents, including tetracyclines, phenicols, sulfonamides, trimethoprim, and fosfomycin. Plasmids, especially multiresistance plasmids, but also other mobile genetic elements, such as transposons and gene cassettes in class 1 and class 2 integrons, seem to play a major role in the dissemination of resistance genes. Of note, coselection and persistence of resistances to critically important antimicrobial agents in human medicine also occurs through the massive use of antimicrobial agents in veterinary medicine, such as tetracyclines or sulfonamides, as long as all those determinants are located on the same genetic elements.

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Section: Clavulanic-acid Inhibited Class a Esblsmentioning

confidence: 99%

Section: Clavulanic-acid Inhibited Class a Esblsmentioning

confidence: 99%

Section: Clavulanic-acid Inhibited Class a Esblsmentioning

confidence: 99%

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Antimicrobial Resistance inEscherichia coli

et al. 2018

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“…Moreover, raw milks are also reportedly contaminated with ESBL producers 173,174) , though drinking of non-sterilized raw milk is prohibited in many countries. Among the livestock meats, it is well known that raw chicken meat is often contaminated with ESBL producers 167,169,175) also in Japan 45,176) , because ESBL-producing E. coli usually colonizes in the intestine of livestock including poultry 177) . Some broad-spectrum cephalosporins such as ceftiofur and cefquinome have been approved and prescribed as veterinary medicines for cattle and porcine, but these agents are not approved for poultry in Japan.…”

Section: -2 Probable Acquisition Of Esbl-producing E Coli Via Foodsmentioning

confidence: 99%

ESBL-producing <i>Escherichia coli</i> and Its Rapid Rise among Healthy People

et al. 2017

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Since around the 2000s, Escherichia coli (E. coli) resistant to both oxyimino-cephalosporins and fluoroquinolones has remarkably increased worldwide in clinical settings. The kind of E. coli is also identified in patients suffering from communityonset infectious diseases such as urinary tract infections. Moreover, recoveries of multi-drug resistant E. coli from the feces of healthy people have been increasingly documented in recent years, although the actual state remains uncertain. These E. coli isolates usually produce extended-spectrum β-lactamase (ESBL), as well as acquisition of amino acid substitutions in the quinolone-resistance determining regions (QRDRs) of GyrA and/or ParC, together with plasmid-mediated quinolone resistance determinants such as Qnr, AAC(6')-Ib-cr, and QepA. The actual state of ESBL-producing E. coli in hospitalized patients has been carefully investigated in many countries, while that in healthy people still remains uncertain, although high fecal carriage rates of ESBL producers in healthy people have been reported especially in Asian and South American countries. The issues regarding the ESBL producers have become very complicated and chaotic due to rapid increase of both ESBL variants and plasmids mediating ESBL genes, together with the emergence of various "epidemic strains" or "international clones" of E. coli and Klebsiella pneumoniae harboring transferable-plasmids carrying multiple antimicrobial resistance genes. Thus, the current state of ESBL producers outside hospital settings was overviewed together with the relation among those recovered from livestock, foods, pets, environments and wildlife from the viewpoint of molecular epidemiology. This mini review may contribute to better understanding about ESBL producers among people who are not familiar with the antimicrobial resistance (AMR) threatening rising globally.

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“…Recently, ESBL-producing Escherichia coli isolates have been increasingly detected in clinical settings, healthy humans, food-producing animals, companion animals, and the environment (1,2). The third-generation cephalosporins are frequently used in both clinical settings and the veterinary field; therefore, the widespread distribution of ESBL producers has become a major public health concern.…”

Section: Introductionmentioning

confidence: 99%