Extended spectrum beta-lactamase-producing Escherichia coli surveillance in the human, food chain, and environment sectors: Tricycle project (pilot) in Indonesia

Puspandari, Nelly; Sunarno, Sunarno; Febrianti, Tati; Febriyana, Dwi; Saraswati, Ratih Dian; Rooslamiati, Indri; Amalia, Novi; Nursofiah, Sundari; Hartoyo, Yudi; Herna, Herna; Mursinah, Mursinah; Muna, Fauzul; Aini, Nurul; Risniati, Yenni; Dhewantara, Pandji Wibawa; Allamanda, Puttik; Wicaksana, Dwi Nawang; Sukoco, Rinto; Efadeswarni,; Nelwan, Erni Juwita; Cahyarini,; Haryanto, Budi; Sihombing, Benyamin; Magalhães, Ricardo J. Soares; Kakkar, Manish; Setiawaty, Vivi; Matheu, Jorge

doi:10.1016/j.onehlt.2021.100331

Cited by 22 publications

(15 citation statements)

References 27 publications

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“…Table 1 shows that ESBL-producing E. coli data on GLASS activities are similar to previous published Tricycle Project data [16] . In general, Indonesia has a high level of resistance to E. coli and K. pneumoniae to third generation cephalosporin antibiotics (ceftriaxon, ceftazidime and cefotaxime), similar to that possessed by Myanmar and Laos ( Figure 1 ).…”

Section: Blood Stream Infection and Urinary Tract Infection Caused By...supporting

confidence: 78%

“…The World Health Organization (WHO) has responded to several activities, including the Global antimicrobial resistance surveillance system (GLASS) and the Tricycle Project [15] , [16] . GLASS is focused on monitoring antimicrobial resistance against several types of bacteria, including E. coli and K. pneumoniae .…”

Section: Global Antimicrobial Resistance Surveillance System (Glass) ...mentioning

confidence: 99%

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Extended spectrum beta lactamase (ESBL)-producing Escherichia coli and Klebsiella pneumoniae in Indonesia and South East Asian countries: GLASS Data 2018

Sunarno

Puspandari

Wang³

et al. 2023

AIMSMICRO

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<abstract> Antimicrobial resistance is the rising global health issue that should not be ignored. This problem needs to be addressed and professionally handled since it is starting to threaten global health, which eventually could lead to disaster. Extended spectrum beta lactamase (ESBL)-producing bacteria were found threatening lives, since most antibiotics were found to not be effective in treating patients with infections caused by those bacteria. ESBL-producing <italic>Escherichia coli</italic> and <italic>Klebsiella pneumoniae</italic> are the two most reported bacteria in causing the bacteremia and nosocomial infections worldwide. In this article, the prevalence of ESBL-producing <italic>E. coli</italic> and <italic>K. pneumoniae</italic> in causing blood stream and urinary tract infections in Indonesia were compared to the neighboring countries based on the global antimicrobial resistance surveillance system performed worldwide by World Health Organization (WHO). In this article, the prevalence of ESBL-producing <italic>E. coli</italic> and <italic>K. pneumoniae</italic> in Indonesia and its neighboring countries were assayed and compared in order to evaluate the antimicrobial resistances. By comparing the prevalence data to the neighboring countries, some insightful evidence and information was served to support improved health in Indonesia. Some hurdles and strategies in combating the antimicrobial resistances were further discussed. Eventually, an alternate solution to overcome the antimicrobial drug resistance should be well-provided, studied and implemented globally. </abstract>

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Section: Blood Stream Infection and Urinary Tract Infection Caused By...supporting

confidence: 78%

Section: Global Antimicrobial Resistance Surveillance System (Glass) ...mentioning

confidence: 99%

Extended spectrum beta lactamase (ESBL)-producing Escherichia coli and Klebsiella pneumoniae in Indonesia and South East Asian countries: GLASS Data 2018

Sunarno

Puspandari

Wang³

et al. 2023

AIMSMICRO

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“…This study, which is part of the "One Health" study conducted by the Centre for Biomedical Research and Development and Basic Health Technology of the Indonesian Ministry of Health, provides a well-detailed investigation of risk factors for ESBLproducing E. coli bacteremia in two referral hospitals in Indonesia. 12 Several limitations are present in this study. First, the retrospective nature of this study renders it to rely on secondary data obtained from the paper medical records of the two hospitals previously mentioned.…”

Section: Discussionmentioning

confidence: 88%

Risk factors and mortality outcomes of extended-spectrum beta-lactamase producing Escherichia coli bacteremia: A retrospective cohort study from two Indonesian referral hospitals

Siregar

Nelwan

Eppy³

et al. 2022

F1000Res

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Background: Bacteremia caused by extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli (E. coli) can lead to bloodstream infection and subsequent sepsis which increases morbidity and mortality. Evaluation of risk factors of infection by ESBL-producing E. coli is important as it can decrease inappropriate antibiotic use and mortality rates. This study aimed to identify the risk factors and mortality of bacteremia caused by ESBL-producing E. coli. Methods: This retrospective cohort study included inpatients with confirmed E. coli blood culture examinations from two referral hospitals in Jakarta, Indonesia. Data suspected as risk factors for ESBL-producing E. coli bacteremia (utilization of medical devices, age, Charlson Comorbidity Index, history of hospitalization, and history of antibiotic therapy) were collected for analysis. Clinical profiles and independent risk factors of ESBL-producing E. coli bacteremia associated mortality were also evaluated. Results: A total of 116 subjects were analyzed with 81% aged ≥18 years old. The most common source of infection was the gastrointestinal and intra-abdominal tracts. Malignancy as comorbidity was present in 46.6% subjects. Significant risk factors for developing ESBL-producing E. coli bacteremia were history of antibiotic therapy and utilization of medical devices. The proportion of mortality in ESBL-producing E. coli bacteremia was 55.7% with age and sepsis as its independent risk factors. Conclusions: History of antibiotic therapy and utilization of medical devices were significant risk factors for ESBL-producing E. coli bacteremia. The proportion of mortality in ESBL-producing E. coli bacteremia patients was 55.7% with its independent risk factors being age and sepsis.

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“…Our work has some limitations: (i) only a subset of stool samples from the overall study was analysed, potentially introducing biases, yet the random selection should have reduced this risk; (ii) only the predominant cefotaxime-resistant E. coli isolates present in the faeces were studied, which may not represent the diversity of E. coli isolates in the gut, but does represent the quantitatively predominant E. coli isolates and therefore the ones that constitute the biggest threat in terms of infectious risks and dissemination [43]; (iii) no precise description of the mobile genetic elements that flank the bla CTX-M-15 gene is available, which would improve understanding of the modalities of mobilization of this gene; this will will be the subject of future works. Finally, the search of an ESBL -E. coli reservoir in other environments, such as the food chain (poultry/livestock), water or sediments would help understand the routes of dissemination in a “One Health” approach [11].…”

Section: Discussionmentioning

confidence: 99%

“…Prevalence of ESBL-E. coli faecal carriage in humans is a good indicator of the global burden of antibacterial resistance in a given community [11]. In Africa, the few available studies showed a prevalence of ESBL-E. coli community faecal carriage ranging from 15% to 92% depending on the country, the population studied and the year of stool collection, which is higher than in most high income countries [2][3][4][5][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Faecal carriage of ESBL-producingEscherichia coliin a remote region of Niger

Jacquier

Assao²,

Chau

et al. 2022

Preprint

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Background: Data on extended-spectrum β--lactamase-producing Escherichia coli (ESBL-E. coli) carriage in community settings, especially in developing countries, are scarce. Here, we describe the population structure and molecular characteristics of resistance of ESBL-E. coli faecal isolates in a rural African population. Methods and findings: Between April and May 2017, stools of 383 healthy participants were collected from 20 villages in rural Southern Niger during a clinical trial on ciprofloxacin prophylaxis carried out during a meningococcal meningitis outbreak. Of 383 individuals, 354 (92.4%) were carriers of ESBL-E. coli before any ciprofloxacin intake. A subset of 90 of these ESBL-E. coli containing stools were selected for further analysis, from which 109 different ESBL-E. coli were recovered and whole genome sequenced by short-(Illumina) and long-(Nanopore) reads. Most belonged to the commensal-adapted phylogroup A (91, 83.5%), with high clonal diversity (57 distinct clones). One-quarter harboured the high pathogenicity island previously associated with a longer duration of faecal carriage. The bla CTX-M-15 gene was the major ESBL determinant (107, 98.1%). It was chromosome-integrated in approximately half of the cases (48, 44.9%), at multiple integration sites in diverse chromosomal genetic backgrounds. When plasmid-borne, bla CTX-M-15 was found in a large diversity of incompatibility groups. A single genetic background was found for 20 distinct plasmids, whereas very closely related plasmids were found in different genetic backgrounds in six cases, suggesting plasmid spread among strains. No geographical or social links to resistance patterns were observed. Conclusions: Massive prevalence of community faecal carriage of CTX-M-15-producing E. coli was observed in a rural region of Niger without apparent antibiotic selective pressure. E. coli were highly diverse, well adapted commensal strains, with chromosomal integration of CTX-M-15 encoding gene in almost half of the cases. Evidence of clonal and plasmid spread suggest a risk of sustainable implementation in community faecal carriage.

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Extended spectrum beta-lactamase-producing Escherichia coli surveillance in the human, food chain, and environment sectors: Tricycle project (pilot) in Indonesia

Cited by 22 publications

References 27 publications

Extended spectrum beta lactamase (ESBL)-producing <i>Escherichia coli</i> and <i>Klebsiella pneumoniae</i> in Indonesia and South East Asian countries: GLASS Data 2018

Extended spectrum beta lactamase (ESBL)-producing <i>Escherichia coli</i> and <i>Klebsiella pneumoniae</i> in Indonesia and South East Asian countries: GLASS Data 2018

Risk factors and mortality outcomes of extended-spectrum beta-lactamase producing Escherichia coli bacteremia: A retrospective cohort study from two Indonesian referral hospitals

Faecal carriage of ESBL-producingEscherichia coliin a remote region of Niger

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