Extended-spectrum beta-lactamase-producing bacteria in a tertiary care hospital in Madrid: epidemiology, risk factors and antimicrobial susceptibility patterns

Abstract

Introduction Extended-spectrum beta-lactamase (ESBL) producing bacteria have been increasingly reported as causal agents of nosocomial infection worldwide. Resistance patterns vary internationally, and even locally, from one institution to the other. We investigated the clinical isolates positive for ESBL-producing bacteria in our institution, a tertiary care hospital in Madrid (Spain), during a 2-year period (2007–2008). Methods Clinical and microbiological data were retrospectively reviewed. Two hundred and nineteen patients were included in the study. Results Advanced age, diabetes, use of catheters, previous hospitalization and previous antibiotic treatment were some of the risk factors found among patients. Escherichia coli was the most frequent isolate, and urinary tract the most common site of isolation. Internal Medicine, Intensive Care Unit (ICU) and General Surgery presented the highest number of isolates. There were no outbreaks during the study period. Antibiotic patterns showed high resistance rates to quinolones in all isolates. There was 100% sensitivity to carbapenems. Conclusion Carbapenems continue to be the treatment of choice for ESBL-producing bacteria. Infection control measures are of great importance to avoid the spread of these nosocomial infections.

Frequency, Risk Factors and Antibiotic Sensitivity Pattern of Extended-Spectrum Beta-Lactamase Producing Escherichia coli and Klebsiella pneumoniae Causing Urinary Tract Infection: Experience from a Tertiary Care Hospital of Bangladesh

“…Risk factors are comparable with different study reports through-out the world. 10,[16][17][18][19] Antibiotic sensitivity patterns were also similar. [6][7][8][9][10][16][17][18] Current study had some limitations.…”

Prevalence of co-existence genes and clonal spread of ESBL-producing isolates causing hospital and community-acquired infections in Zenica-Doboj Canton, Bosnia and Herzegovina

“…Correct use of sterile gloves and systematic hand decontamination before and after visiting the patients and visitors' restriction are some of isolation measures (26).…”

Factores de riesgo para infección por Pseudomonas aeruginosa multi-resistente en un hospital de alta complejidad

“…Infecciones Asociadas a la Atención de Salud nos y la estancia hospitalaria prolongada son factores de riesgo para desarrollar procesos infecciosos por esta bacteria en la población estudiada [21][22][23][24][29][30][31] . Adicionalmente, encontramos que por cada día de estancia el riesgo calculado para adquirir una infección por este microorganismo es de 3%, sin asociarse con mayor estancia hospitalaria después del aislamiento microbiológico, contrario a lo reportado por otros autores 26 .…”