Frequency, Risk Factors and Antibiotic Sensitivity Pattern of Extended-Spectrum Beta-Lactamase Producing Escherichia coli and Klebsiella pneumoniae Causing Urinary Tract Infection: Experience from a Tertiary Care Hospital of Bangladesh

Rahim, Muhammad Abdur; Samad, Tabassum; Mitra, Palash; Zaman, Shahana; Habib, Samira Humaira; Afroze, Samira Rahat; Haque, Wasim Md Mohosin Ul; Uddin, Khwaja Nazim

doi:10.3329/birdem.v7i2.32455

Cited by 5 publications

(6 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…8 Patients with diabetes mellitus and specially those with poor glycaemic control are at increased risk for infection with ESBL-positive organisms. 2,[15][16][17] The percentage of ESBL-positive organisms was higher in our study compared to some other international reports. 16,18 Inadvertent and nonjudicious use of antimicrobials may be one of the most important contributory factors for such findings in the present study.…”

Section: Discussioncontrasting

confidence: 63%

“…Urinary tract infection (UTI) is the most common bacterial infection in adults and elderly population and patients with diabetes mellitus are at increased risk for UTI. [1][2][3] UTI, specially pyelonephritis may be complicated by bacteraemia and sepsis. 4,5 Antimicrobials remain the cornerstone for treatment of UTI and increasing antimicrobial resistance, specially extended-spectrum beta-lactamase (ESBL) producing organisms is an ever increasing problem.…”

Section: Introductionmentioning

confidence: 99%

“…[6][7][8][9] ESBL-positive organisms are inherently resistant to penicillin and cephalosporin; thus UTI caused by ESBLpositive organism require injectable agents like carbapenems and aminoglycosides or nitrofurantoin, pivmecillinam and fluoroquinolones; many organisms causing UTI are also resistant to these oral agents. 2,8 Bangladesh J Medicine 2020; 31 : 9-12 Moreover, UTI complicated by bacteraemia indicates complicated infection and merits intravenous antimicrobials in hospital settings; thus increasing treatment cost by many folds. So, this study was designed to evaluate whether UTI due to ESBL-positive organisms is a risk factor for bacteraemia among patients with type 2 diabetes mellitus.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Urinary Tract Infection due to Extended-spectrum Beta-lactamase Producing Organisms is a Risk Factor for Bacteraemia Among Patients with Type 2 Diabetes Mellitus

et al. 2019

Self Cite

View full text Add to dashboard Cite

Introduction: Urinary tract infection (UTI) is common among patients with diabetes mellitus and the aetiological agents are often extended-spectrum beta-lactamase (ESBL) producing bacteria. Diabetic patients with UTI are sometimes complicated by bacteraemia. This study was designed to evaluate whether UTI due to ESBL-positive organisms is a risk factor for bacteraemia among patients with type 2 diabetes mellitus. Methods: This was a cross-sectional analytical study, done in BIRDEM General Hospital, Dhaka, Bangladesh from January to April 2016. Adult (e”18 years) type 2 diabetic subjects of either sex with culture proven UTI were included in this study. All study participants were subjected to undergo blood cultures as well. ESBL-positivity of the infective organisms for UTI was evaluated as possible risk factor for bacteraemia. Results: Total patients were 145 including 119 (82%) females. Eshcerichia coli (112, 77.2%) was the most common aetiological agents followed by Klebsiella pneumoniae (28, 19.3%). In 54 (37.2%) patients UTI was due to ESBL-positive organisms. Ten (6.9%) patients were complicated by bacteraemia [7 (7/ 54, 13%) among patients with UTI due to ESBL-positive organisms and 3 (3/91, 3.3%) among patients with UTI due to non-ESBL organisms]. UTI due to ESBL-positive organisms appeared as a significant risk factor for bacteraemia (OR 4.37, 95% CI 1.08-17.38, p 0.03). Conclusion: Nearly two-fifths of UTI cases were due to ESBL-positive organisms in this study. ESBLpositivity of the causative organisms was a significant risk factor for bacteraemia among type 2 diabetic subjects. Bangladesh J Medicine Jan 2020; 31(1) : 9-12

show abstract

Section: Discussioncontrasting

confidence: 63%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Urinary Tract Infection due to Extended-spectrum Beta-lactamase Producing Organisms is a Risk Factor for Bacteraemia Among Patients with Type 2 Diabetes Mellitus

et al. 2019

Self Cite

View full text Add to dashboard Cite

show abstract

“…15 In our study, we evaluated ESBL-positivity of organisms causing UTI as risk factor for AKI. UTI due to ESBL-positive organisms are increasingly been reported in Bangladesh [16][17][18] and Rahim MA et al 10 reported that diabetic females with long duration and poor glycaemic control are risk factors for UTI due to ESBL-positive organisms. Similar observation was reported in other studies.…”

Section: Discussionmentioning

confidence: 99%

Urinary Tract Infection due to Extended-Spectrum Beta-Lactamase Producing Organisms is a Risk Factor for Acute Kidney Injury among Patients with Type 2 Diabetes Mellitus

et al. 2017

Self Cite

View full text Add to dashboard Cite

Background: Urinary tract infection (UTI) is common and diabetic patients are at increased risk for UTI. UTI may be complicated by acute kidney injury (AKI).the world. 3-6 Extended-spectrum beta-lactamase (ESBL) producing strains are an ever increasing problem 7-9 and diabetic patients with long duration and poor glycaemic control are at increased risk for UTI due to ESBL-positive organisms. 5,10 UTI may be complicated by acute kidney injury (AKI) and sepsis. 3 This study was designed to evaluate whether UTI due to ESBL-positive organisms should be considered as a risk factor for AKI in type 2 diabetic subjects. Methods:This case-control study was done in the Department of Internal Medicine and Department of Nephrology of Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM) General Hospital, Dhaka, Bangladesh from April to June 2016. Hospitalized patients with a clinical diagnosis of UTI were initially enrolled for the study purpose. A clean catch technique was applied for urine (preferably early morning midstream specimen) collection.

show abstract

“…These results agree with another study in India (30%) 33 . Alyamani et al 30 found that all E. coli isolates were sensitive to meropenem and Rahim et al 34 showed that all E. coli isolates were sensitive to impenem. Carbapenemes are now considered the last resort for treatment of infections caused by multidrug-resistant organisms.…”

Section: Discussionmentioning

confidence: 99%

Phenotypic and Molecular Characterization of Aminoglycoside Resistance in Clinical Escherichia coli Isolates from Patients at Menoufia University Hospitals

Ghonaim¹,

Mostafa²,

Alkady³

2019

Egyptian Journal of Medical Microbiology

View full text Add to dashboard Cite

Background: E. coli may develop different complex mechanisms of resistance to various classes of antibiotics. Objectives:To assess the prevalence of E. coli in Menoufia University Hospitals, to evaluate its antibiotic resistance profile and to detect the presence of aminoglycoside resistance genes [aac(3)IIa and aac( 6)Ib] by real-time polymerase chain reaction (PCR). Methodology: A total of 200 clinical samples were collected from patients in Menoufia University Hospitals. E. coli was identified by standard microbiological methods. E. coli isolates were tested by the modified Kirby-Bauer disk diffusion method, and for extended-spectrum β-lactamases production. Aac(3)IIa and aac(6)Ib genes were detected by real-time PCR. Results: E. coli forms 25% of the isolated bacterial strains. E. coli isolates showed the highest resistance to pipracillin and amoxicillin-clavulanate (96%). On the other hand, carbapenemes had the least resistance rate (30%) followed by amikacin (44%), gentamicin (60%), tobramycin (60%) and streptomycin (64%). ESβL production was found among 70% of the isolates by the screening and 50% by the confirmatory methods. Real-time PCR showed that 84% of the isolates contain aac(3)IIa, 52% contain aac(6)Ib and 46% contain both genes. Conclusion: E. coli showed resistance to different classes of antibiotics including aminoglycosides with high prevalence of aac(3)IIa and aac(6)Ib genes. Therefore, infection control measures and rationalized use of antibiotics are mandatory.

show abstract

Frequency, Risk Factors and Antibiotic Sensitivity Pattern of Extended-Spectrum Beta-Lactamase Producing Escherichia coli and Klebsiella pneumoniae Causing Urinary Tract Infection: Experience from a Tertiary Care Hospital of Bangladesh

Abstract: Background: Urinary tract infection (UTI) due to extended-spectrum beta-lactamase (ESBL) producing

Cited by 5 publications

References 16 publications

Urinary Tract Infection due to Extended-spectrum Beta-lactamase Producing Organisms is a Risk Factor for Bacteraemia Among Patients with Type 2 Diabetes Mellitus

Urinary Tract Infection due to Extended-spectrum Beta-lactamase Producing Organisms is a Risk Factor for Bacteraemia Among Patients with Type 2 Diabetes Mellitus

Urinary Tract Infection due to Extended-Spectrum Beta-Lactamase Producing Organisms is a Risk Factor for Acute Kidney Injury among Patients with Type 2 Diabetes Mellitus

Phenotypic and Molecular Characterization of Aminoglycoside Resistance in Clinical Escherichia coli Isolates from Patients at Menoufia University Hospitals

Contact Info

Product

Resources

About