Extended release of dexamethasone from silicone-hydrogel contact lenses containing vitamin E

Synthesis and Characterization of Poly(2-hydroxyethylmethacrylate) Contact Lenses Containing Chitosan Nanoparticles as an Ocular Delivery System for Dexamethasone Sodium Phosphate

“…This approach uses the hydrophobic vitamin to create a more tortuous path for, in particular, hydrophilic drugs to diffuse through as they migrate from the lens to the eye, extending the delivery period for up to as much as a factor of 400 for timolol [12] and 16 for the hydrophobic drug, dexamethasone [13]. The same group have also used nanoparticles prepared from both PGT [14,15] and silica-stabilised emulsions [16] for their incorporation into lenses.…”

PLA/PEG-PPG-PEG/Dexamethasone implant prepared by hot-melt extrusion for controlled release of immunosuppressive drug to implantable medical devices, part 2:in vivoevaluation

“…This study presents a novel strategy for suppressing the inflammatory response to implantable medical devices. A new implant prepared by HME and benefits of this technique include solvent-free, environmental-friendly and cost-efficient technology (Kim et al, 2010). Furthermore, HME improves bioavailability by forming solid dispersions and solid solutions (Krenzlin et al, 2012).…”

Chitosan/alginate based multilayers to control drug release from ophthalmic lens

“…(1) incorporation of chemical agents that can interact reversibly with the drug [7]; (2) the use of nanocarriers, such as micelles, liposomes or nanoparticles [8,9]; (3) introduction of diffusion barriers to the drugs, such as Vitamin E aggregates [10,11].…”