Extended multiorgan resection in locally advanced gastric cancer: a single centre experience from south India

Deshpande, Gayatri

doi:10.7869/tg.144

Cited by 2 publications

(2 citation statements)

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“…Poor tumor biology may be an unmodifiable factor. However, completeness of resection and performing aggressive surgery safely, including multi-visceral resections, may need to be explored given that R0 resection and adequate lymphadenectomy offer better survival rates [26]. …”

Section: Discussionmentioning

confidence: 99%

Surgical Outcomes Associated with Operable Gastric Cancer in a Tertiary Care Indian Hospital

et al. 2017

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PurposeData on operable gastric cancer from India is sparse. The purpose of this study was to investigate the clinical details, histopathological demographics, and 5-year overall survival (OS) and disease free survival (DFS) associated with operable, non-metastatic gastric cancer in a dedicated upper gastrointestinal (GI) surgical unit in India.Materials and MethodsData for patients diagnosed with operable gastric cancer between January 2006 and December 2014 were retrospectively analyzed. Data were collected from electronic hospital records in addition to mail and telephonic interviews when possible.ResultsA total of 427 patients were included. The tumor was located in the pyloro-antral region in 263 patients (61.7%). Subtotal gastrectomy was performed in 291 patients and total gastrectomy in 136 patients. Tumor stage classification revealed 43 patients (10.0%) with stage I, 40 patients (9.4%) with stage IIA, 59 patients (13.9%) with stage IIB, 76 patients (17.8%) with stage IIIA, 96 patients (22.5%) with stage IIIB, and 113 patients (26.4%) with stage IIIC disease. Follow-up data were available for 71.6% of the patients with a mean duration of 32.4 months. Five-year DFS and OS were 39% and 59%, respectively.ConclusionsDespite presenting at an advanced stage, the 5-year DFS and OS of patients with operable gastric cancer treated at a dedicated upper GI unit of a tertiary care center in India was good.

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Section: Discussionmentioning

confidence: 99%

Surgical Outcomes Associated with Operable Gastric Cancer in a Tertiary Care Indian Hospital

et al. 2017

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“…One of the regions that were not covered in this review is India. One proceeding publication by Deshpande et al [47] presents a nuanced exploration of the outcomes associated with extended MOR for LAGC, a subject mired in controversy regarding its prognostic and survival benefits. The study reports a perioperative morbidity rate of 25% and a mortality rate of 5.5%, alongside a median survival time of 28 months.…”

Section: Summary Of Evidencementioning

confidence: 99%

Analysis of Patient Outcomes following Curative R0 Multiorgan Resections for Locally Advanced Gastric Cancer: A Systematic Review and Meta-Analysis

Dejeu,

Muresan

et al. 2024

JCM

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Background: This systematic review examines the efficacy of multiorgan resection (MOR) in treating locally advanced gastric cancer (LAGC), focusing on survival outcomes, postoperative morbidity, and mortality. Methods: We conducted a comprehensive search of studies in PubMed, Scopus, and Embase up to November 2023, based on the PRISMA guidelines. The inclusion criteria focused on clinical trials, observational studies, case–control studies, and qualitative research, involving patients of any age and gender diagnosed with LAGC undergoing MOR aimed at R0 resection, with secondary outcomes focusing on survival rates, postoperative outcomes, and the effects of adjuvant and neoadjuvant therapies. Exclusion criteria ruled out non-human studies, research not specifically focused on LAGC patients undergoing MOR, and studies lacking clear, quantifiable outcomes. The quality assessment was performed using the Newcastle–Ottawa Scale. The final analysis included twenty studies, involving a total of 2489 patients across a time span from 2001 to 2023. Results highlighted a significant variation in median survival times ranging from 10 to 27 months and R0 resection rates from 32.1% to 94.3%. Survival rates one-year post-R0 resection varied between 46.7% and 84.8%, with an adjusted weighted mean of 66.95%. Key predictors of reduced survival included esophageal invasion and peritoneal dissemination, the presence of more than six lymph nodes, and tumor sizes over 10 cm. Nevertheless, the meta-analysis revealed a significant heterogeneity (I2 = 87%), indicating substantial variability across studies, that might be caused by differences in surgical techniques, patient demographics, and treatment settings which influence survival outcomes. Results: The review underlines the important role of achieving R0 resection status in improving survival outcomes, despite the high risks associated with MOR. Variability across studies suggests that local practice patterns and patient demographics significantly influence results. Conclusions: The findings emphasize the need for aggressive surgical strategies to improve survival in LAGC treatment, highlighting the importance of achieving curative resection despite inherent challenges.

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Extended multiorgan resection in locally advanced gastric cancer: a single centre experience from south India

Cited by 2 publications

References 20 publications

Surgical Outcomes Associated with Operable Gastric Cancer in a Tertiary Care Indian Hospital

Surgical Outcomes Associated with Operable Gastric Cancer in a Tertiary Care Indian Hospital

Analysis of Patient Outcomes following Curative R0 Multiorgan Resections for Locally Advanced Gastric Cancer: A Systematic Review and Meta-Analysis

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