“…The data of the present study demonstrate a gradual diminution of high-frequency sensitivity through adolescence and young adulthood. A loss of hearing sensitivity over the frequency range of 15-18 kHz, which starts at around 20 years of age, has been demonstrated by many authors (Schechter et al, 1986;Stelmachowicz et al, 1989;Trehub et al, 1989;Reuter et al, 1997). Hearing loss is usually thought to result from age-related changes in metabolism and in connective tissues, degeneration of the neurons of the cochlear nerve, and mechanical changes in the organ of Corti, which have adverse effects on the peripheral auditory structures, or degenerative changes in the major auditory pathways and centers of the brain (Brizzee et al, 1980;Trehub et al, 1989;Schuknecht and Gacek, 1993;Mazelova et al, 2003).…”