Expressions of p53, cyclinD1 and histopathological features in basal cell carcinomas

Abstract

P53 expression seems to be related to Ki67 index and some histopathological features of BCC, such as infiltrative histological growth pattern and probably fibrosis.

Genital basal cell carcinoma, a different pathogenesis from sun‐exposed basal cell carcinoma? A case‐control study of 30 cases

“…18 Aggressive BCCs, especially infiltrative and basosquamous subtypes, have higher rates of p53 positivity and higher mean Ki-67 index values. 18,22 However, in our study, overexpression of the p53 protein was more commonly observed in genital BCCs, of which 85% belonged to nodular or superficial types. Therefore, the overexpression of p53 in genital BCCs likely results from factors other than UV-specific 23 In European patients, 72% of mutations displayed a typical UV-signature.…”

“…Epidermal p53 clones are clusters of morphologically normal keratinocytes with intense nuclear accumulation of immunoreactive p53. 22,24 Such p53 clones are frequently found in chronically sunexposed skin, and the mutations of epidermal p53 clones are mostly missense and represent the typical UV signature. 24 However, 40% of epidermal p53 clones lack an underlying p53 mutation.…”

Immunohistochemical evaluation of p53 and Ki67 expression in skin epithelial tumors

“…[1–5] Incidence rates have been reported to be between 20 and 300/1,000,000 in Europe and Northern America. [6]…”

“…Although a positive correlation between clinicopathological aggressiveness and p53 immunoreactivity has usually been suggested in the literature, some authors have reported contradictory results. [6]…”

“…The proliferation index determined by Ki67 immunostaining has a prognostic value in certain types of cancers. [6] The expression of proliferation marker, Ki67, is also increased in sun-damaged skin [Figure 2]. [21]…”