Expressions of p53, cyclinD1 and histopathological features in basal cell carcinomas

Köseoğlu, Reşit Doğan; Sezer, Engin; Eyibilen, Ahmet; Aladağ, İbrahim; Etikán, Ílker

doi:10.1111/j.1600-0560.2009.01204.x

Cited by 13 publications

(8 citation statements)

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“…Previous studies have found p53 expression in cutaneous neoplasms to vary between 42% and 84% (17,18). In our study, the expression was found to be 81.8%.…”

Section: Discussionsupporting

confidence: 65%

Evaluation of p53 and ki67 expression profiles in basal cell carcinomas in a usual and an unusual location

Süngü¹,

Kıran²,

Doğan³

et al. 2018

TJPATH

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Objective: Owing to their importance in cell proliferation in cutaneous malignancies, we aimed to immunohistochemically compare the expression profiles of p53 and Ki67 in basal cell carcinoma (BCC) cases in both a usual and an unusual locations in this study. Material and Method:In this study we included 12 in an unusual location of BCC cases and 21 BCC cases in a usual location. Immunohistochemical expression of p53 and Ki67 antibodies were studied in 33 paraffin-embedded tissue specimens of basal cell carcinoma. We compared the p53 and Ki67 staining scores with clinicopathologic features. Results:The tumor size was found to be greater in BCC cases in an unusual location than those in a usual location. The relationship between age and tumor size was also evaluated in both groups and it was found that tumor size increased with age. A comparative study between the two groups showed no difference p53 and Ki67 expression percentages. There was a linear correlation between the Ki67 and p53 marker staining rates (ρ=0.420; p=0.015). In the samples taken from cases in a usual region, there was a linear and moderate relationship between the markers (ρ=0.513; p=0.017). Median tumor diameter results were similar to the marker staining score (p>0.05). Conclusion:This is the first study comparing the expression profiles of p53 and Ki67 of BCC cases in an unusual and a usual location. No significant difference was found concerning Ki67 and p53 expression levels between the two groups.

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“…Previous studies have found p53 expression in cutaneous neoplasms to vary between 42% and 84% (17,18). In our study, the expression was found to be 81.8%.…”

Section: Discussionsupporting

confidence: 65%

Evaluation of p53 and ki67 expression profiles in basal cell carcinomas in a usual and an unusual location

Süngü¹,

Kıran²,

Doğan³

et al. 2018

TJPATH

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“…BCCs that occur in sun‐exposed sites more frequently show p53 overexpression than do those in less‐exposed areas . Aggressive BCCs, especially infiltrative and basosquamous subtypes, have higher rates of p53 positivity and higher mean Ki‐67 index values . However, in our study, overexpression of the p53 protein was more commonly observed in genital BCCs, of which 85% belonged to nodular or superficial types.…”

Section: Discussioncontrasting

confidence: 64%

“…Epidermal p53 clones are clusters of morphologically normal keratinocytes with intense nuclear accumulation of immunoreactive p53 . Such p53 clones are frequently found in chronically sun‐exposed skin, and the mutations of epidermal p53 clones are mostly missense and represent the typical UV signature .…”

Section: Discussionmentioning

confidence: 99%

“…Our study showed that the epidermal p53 clone is shorter in the overlying epidermis of genital BCCs compared to sun‐exposed BCCs. Therefore, whether epidermal p53 clones are forerunners of BCC remains controversial, and their role in the development of genital BCCs is of little significance . Overall, the etiology of genital BCC remains poorly understood, although radiotherapy to the pelvic region, arsenic exposure, chronic skin irritation, previous trauma, and immunosuppressed status are suspected risk factors.…”

Section: Discussionmentioning

confidence: 99%

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Genital basal cell carcinoma, a different pathogenesis from sun‐exposed basal cell carcinoma? A case‐control study of 30 cases

et al. 2018

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“…Expression of RAR was almost significantly lower in BCCs than in control tissues (p=0.056). The expression of the www.intechopen.com (100,106,107,158,161) and by the apoptotic index (124). The markers Ki-67 and p53 can impart supplementary information and are important for histopathological diagnosis with regard to making a clinical judgement of the consequences of "tumor-free margin".…”

Section: Biomarkers For Chemoprevention Of Basal Cell Carcinomasmentioning

confidence: 99%

Molecularbiology of Basal Cell Carcinoma

Fabricius¹,

Hoffmeister²,

Raguse³

2012

Basal Cell Carcinoma

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Expressions of p53, cyclinD1 and histopathological features in basal cell carcinomas

Abstract: P53 expression seems to be related to Ki67 index and some histopathological features of BCC, such as infiltrative histological growth pattern and probably fibrosis.

Cited by 13 publications

References 50 publications

Evaluation of p53 and ki67 expression profiles in basal cell carcinomas in a usual and an unusual location

Evaluation of p53 and ki67 expression profiles in basal cell carcinomas in a usual and an unusual location

Genital basal cell carcinoma, a different pathogenesis from sun‐exposed basal cell carcinoma? A case‐control study of 30 cases

Molecularbiology of Basal Cell Carcinoma

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