Expression, purification and characterization of the IcmG and IcmK proteins of the type IVB secretion system from Coxiella burnetii

Mathioudaki, Eirini; Arvaniti, Katerina; Muenke, Cornelia; Drakonaki, Athina; Vranakis, Iosif; Koutantou, Myrto; Psaroulaki, Anna; Xie, Hao; Tsiotis, Georgios

doi:10.1016/j.pep.2021.105905

Cited by 4 publications

(1 citation statement)

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“…For example, compared with normal adrenal tissue, the expression of ADPRC, aldosterone synthase gene (CYP11B2), and angiotensin II receptor (AT1R) gene in aldosterone adenoma increased (Takeda et al, 2005). Therefore, studying the main biological functions, relationship with human health and diseases, related signaling pathways and mechanisms, and activity regulatory factors of ADPRC is of great significance for the diagnosis and targeted therapy of human diseases (Mathioudaki et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Adenosine diphosphate ribose cyclase: An important regulator of human pathological and physiological processes

Zeng

Zhu

Liao

et al. 2022

Journal Cellular Physiology

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Adenosine diphosphate ribose cyclase (ADPRC) exists widely in eukaryotes and lower metazoans cells. It can degrade nicotinamide adenine dinucleotide (NAD) into cyclic ADP ribose (cADPR) and nicotinamide, and subsequently hydrolyses cADPR to ADP ribose (ADPR). In this paper, we have summarized the relative subcellular localization of ADPRC and enzymes with ADPRC activity in organisms, related enzyme family members of ADPRC are also described. In addition, we discussed the main biological functions of ADPRC, the regulation of Ca 2+ signal, the regulation of insulin and glucagon secretion, oxytocin secretion, and the effects of renal and pulmonary vasomotor tension. Finally, we expounded the relationship between ADPRC and human health and disease occurrence. It provides a theoretical basis for the targeted treatment of ADPRC as a pharmacological tool for related diseases, and has important significance in clinical diagnosis and disease intervention.

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Section: Introductionmentioning

confidence: 99%