Expression Profiles of tRNA-Derived Fragments and their Potential Roles in Ovarian Endometriosis

Shen, Licong; Hong, Xiaxia; Zhou, Wenjun; Zhang, Yi

doi:10.2217/epi-2019-0277

Cited by 18 publications

(27 citation statements)

References 27 publications

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“…tRNA-derived fragments are dysregulated, which could be involved in the pathogenesis and progression of ovarian endometriosis [14]. There were significantly expressed tRNA-derived fragments in breast cancer tissues, which are hopefully to become biomarkers and valuable researches in this area [15].…”

Section: Introductionmentioning

confidence: 99%

Differential Expression Profiles and Function Prediction of Transfer RNA-Derived Fragments in High-Grade Serous Ovarian Cancer

Chen

Wang

Li³

et al. 2021

BioMed Research International

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Background. The present study is aimed at providing systematic insight into the composition and expression of transfer RNA (tRNA) derivative transcription in high-grade serous ovarian cancer (HGSOC). Methods. tRNA derivative expression profiles in three pairs of HGSOC and adjacent normal ovarian tissues were conducted by tRNA-derived small RNA fragment (tRF) and tRNA half (tiRNA) sequencing. The differentially expressed tRFs and tiRNAs between HGSOC and paired adjacent normal samples were screened. The targeted genes of differentially expressed tRFs and tiRNAs were screened. The Gene Ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG) of target genes of tRFs and tiRNAs were analyzed. Results. There are a total of 20 significantly upregulated and 15 significantly downregulated tRFs and tiRNAs between the cancer group and the paracarcinoma group. The upregulated tRFs and tiRNAs are mucin-type O-glycan biosynthesis, glycosphingolipid biosynthesis, the glucagon signaling pathway, the AMPK signaling pathway, maturity-onset diabetes of the young, glycosphingolipid biosynthesis, the insulin signaling pathway, insulin resistance, leukocyte transendothelial migration, starch, and sucrose metabolism. The downregulated tRFs and tiRNAs are other glycan degradation, vitamin digestion and absorption, fatty acid elongation, and biosynthesis of unsaturated fatty acids. Conclusions. There are significantly expressed tRFs and tiRNAs in HGSOC tissues, and these may provide potential diagnostic biomarkers and therapeutic targets for HGSOC.

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Section: Introductionmentioning

confidence: 99%

Differential Expression Profiles and Function Prediction of Transfer RNA-Derived Fragments in High-Grade Serous Ovarian Cancer

Chen

Wang

Li³

et al. 2021

BioMed Research International

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“…In addition, of differentially expressed tRFs/tiRNAs. 86 The bioinformatic analysis of predicting downstream targets is not yet complete, which hinders the study of tsRNAs. Therefore, tsRNA research needs to overcome these limitations in order to achieve long-term development.…”

Section: Tsrnas Exist In Microvesicles and Exosomesmentioning

confidence: 99%

tsRNAs: Novel small molecules from cell function and regulatory mechanism to therapeutic targets

et al. 2021

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In 1958, Francis Crick proposed the central dogma of molecular biology: that genomic DNA in the nucleus is transcribed into messenger RNA (mRNA), which is then translated into proteins when it enters the cytoplasm. It is traditionally believed that, at the initial stage of translation, amino acids and their homologous tRNAs undergo aminoacylation through the action of aminoacyl-tRNA synthetase (AARS) to form an aminoacyl-tRNA complex (aa-tRNA). 1,2 Then, aa-tRNA specifically recognizes the codon on the mRNA sequence, binds to the rR-NA-mRNA complex and connects the corresponding amino acid to the polypeptide chain under the action of rRNA so that the polypeptide

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“…For example, in one study, qRT-PCR screened a total of 48 DE tRFs/tiRs in pancreatic cancer samples compared with adjacent normal tissue samples, including 46 upregulated tRFs/tiRs and 2 downregulated tRFs/tiRs [ 58 ]. A study investigating ovarian endometriosis [ 59 ] identified 19 upregulated and 5 downregulated tRFs, of which tiR-5s were the most common. In a study investigating high-grade serous ovarian cancer (HGSOC) [ 60 ], 2165 tRFs were found to be expressed in the sera of HGSOC patients and healthy controls.…”

Section: Trfs In Human and Animal Agingmentioning

confidence: 99%

“…High-throughput sequencing and qRT-PCR were used in one study to detect the expression of tRFs in pancreatic cancer tissues and adjacent normal tissues. In total, 48 tRFs and tiRs were identified in pancreatic cancer samples [ 59 ]. Some tRFs and tiRs were selected and verified by qRT-PCR, and the results were consistent with the sequencing results [ 59 ].…”

Section: Trfs In Age-related Diseasesmentioning

confidence: 99%

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tRNA-derived fragments as New Hallmarks of Aging and Age-related Diseases

Yuán¹,

Li²,

He³

et al. 2021

Aging and disease

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Expression Profiles of tRNA-Derived Fragments and their Potential Roles in Ovarian Endometriosis

Cited by 18 publications

References 27 publications

Differential Expression Profiles and Function Prediction of Transfer RNA-Derived Fragments in High-Grade Serous Ovarian Cancer

Differential Expression Profiles and Function Prediction of Transfer RNA-Derived Fragments in High-Grade Serous Ovarian Cancer

tsRNAs: Novel small molecules from cell function and regulatory mechanism to therapeutic targets

tRNA-derived fragments as New Hallmarks of Aging and Age-related Diseases

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