“…In support of this observation, sexually dimorphic levels of GMC cyp19 in G. rugosa have been reported 2 weeks earlier than cyp17 and foxl2 [Ohtani et al, 2003;Iwade et al, 2008;Maruo et al, 2008;Oshima et al, 2008Oshima et al, , 2009Sakurai et al, 2008;Suda et al, 2011b]. Together, these results support the use of cyp19 as an early ovarian differentiation marker in amphibians, as has been proposed for fish [Fernandino et al, 2008;Blázquez et al, 2009].…”